Stylianos Lefkopoulos (he/him)

Graphic promoting the Springer Nature “Opening Doors Internship Programme 2026.” The design features bold, colorful abstract shapes in purple, orange, and blue. On the left, logo for “Be part of progress.” On the right, text states “Opening Doors Internship Programme 2026 – Accepting applications,” alongside the Springer Nature logo and the “Stretch Your Horizons” branding. A young woman is seated in the foreground.

Our Opening Doors Internship Programme is open for applications! #BePartOfProgress and join one of our teams to gain hands-on experience working on impactful projects and benefit from the expertise of our talented colleagues.
spklr.io/63327DL797

#Publishing #WorkInPublishing

Lack of MDA5 delays hematopoietic aging by modulating inflammaging and proteostasis in mice - Nature Communications Exposure to inflammation drives hematopoietic stem cells (HSC) aging, limiting their self-renewal capacity and differentiation. Here, the authors explore the mechanistic link between inflammation and ...

Our work is out www.nature.com/articles/s41...

👋Our February issue is out!
Cover: spatial #transcriptomics

👉Review: telomeric #chromatin
🔬 #mitochondria #mitophagy #senescence #p53 #epigenetics #glioblastoma #IDR #immunotherapy #cGASSTING #apoptosis #lysosomes & more!

www.nature.com/ncb/volumes/...

Tumour acidosis remodels the glycocalyx to control lipid scavenging and ferroptosis - Nature Cell Biology Bång-Rudenstam et al. report that the acidic tumour microenvironment facilitates the assembly of chondroitin sulfate-enriched glycocalyx to disrupt lipid scavenging and prevent ferroptosis, thereby pr...

☕Bång-Rudenstam et al. report that the acidic #tumor microenvironment facilitates the assembly of chondroitin sulfate-enriched glycocalyx to disrupt lipid scavenging and prevent #ferroptosis, thereby providing an adaptive mechanism upon tumor acidosis.
bit.ly/3Mvuvz1

Thank you for your contribution!

The interpretable multimodal dimension reduction framework SpaHDmap enhances resolution in spatial transcriptomics - Nature Cell Biology Tang, Chen, Qian et al. present a multimodal, interpretable dimension reduction framework called SpaHDmap, which leverages histology images and enhances the resolution of spatial transcriptomics, thus...

☕Tang, Chen, Qian et al. present a multimodal, interpretable dimension reduction framework called SpaHDmap, which leverages #histology images and enhances the resolution of spatial #transcriptomics, thus enabling the dissection of complex tissue structures.
bit.ly/4chkfoD

T follicular helper cells transiently unlock a plasticity state in germinal centre B cells during the humoral immune response - Nature Cell Biology Scourzic et al. show that germinal centre B cells display an enhanced ability to reprogram to induced pluripotent stem cells compared to mature B cells. This ability indicates their higher plasticity ...

☕Scourzic et al. showed that germinal centre #Bcells display an enhanced ability to #reprogram to induced pluripotent stem cells compared to mature B cells. This ability indicates their higher #plasticity level and is T follicular helper cell-dependent.
👉https://rdcu.be/e2Wxm
bit.ly/4aDyDWY

Bring structure to your research - protocols.io A secure platform for developing and sharing reproducible methods.

Join Springer Nature editors and the protocols.io team for an exciting event as part of #LoveMethods26!
🔮Gain insight on methods publishing at our Methods Mythbusting on Jan 22. Our editor Sabrya Carim will be there!
👉FREE registration & more details:
www.protocols.io/blog/join-pr...

Modelling co-development between the somites and neural tube in human trunk-like structures - Nature Cell Biology Makwana, Tilley et al. generate human stem cell-based trunk-like structures approximating Carnegie stage 13–14 of development. They use them to model and study the development of the thoracic and lumb...

🥂Congratulations to @nmoris.bsky.social & co for their study in our journal generating human stem cell-based trunk-like structures approximating Carnegie stage 13–14 of development. They use them to model and study the development of the thoracic and lumbar trunk.
bit.ly/3LoaXw2

🎆 Happy new year and our first 2026 issue is out!
Cover: #epiblast development

👉Perspective: biological clocks
👉Review: #mitosis #CellDeath #inflammation
🔬 #chromatin #cancer #Bcells #Tcells #autophagy #organoids #mechanobiology #TranscriptionFactors #Xist & more!

www.nature.com/ncb/volumes/...

I wouldn’t know - never been to Norway. Hope i can get a chance soon!

What a lovely view to return to work to! Have I said before how much I love living in Berlin?

Tip 4: Make it EASY. Avoid “empty” statements or fancy writing (that’s coming from sbd struggling with their fluffy writing habits). A good writer (in general and especially in science) does just one thing: makes sure every reader understands. Accurate, clean/short sentences, specific, **EASY**.

Tip 3: Be “conservative” (it’s the only case where I recommend it 😝). Stick to the big picture, yes, but by presenting the data that you actually have in the paper. Don’t overpromise. *Don’t present potential interpretations as results*. Don’t make a general discussion - be very specific and clear.

Tip 2: Ask yourself what you would like to read in an abstract of a study on an area that you ‘re not familiar with. The point of an abstract is not to show you have a lot of data nor present every new observation you made; it’s rather to help the reader get the major question and the major answer.

A human epiblast model reveals dynamic TGFβ-mediated control of epithelial identity during mammalian epiblast development - Nature Cell Biology The authors optimize an in vitro human epiblast model, which they utilize to show that early TGFβ family inhibition prevents epithelial identity, whereas it is dispensable after epithelium formation. ...

🥂Congratulations to @grazianomartello.bsky.social & co: they optimize an in vitro human #epiblast model, which they use to show that early #TGFβ family inhibition prevents epithelial identity, while it is dispensable after epithelium formation.
👉https://rdcu.be/eVPMa

www.nature.com/articles/s41...

🥂 Happy 2026 all! I 'm looking forward to working with as many of you as possible this year! I 'll be back in the office on Monday, so feel free to shoot emails for meetings and papers you might wanna discuss for @natcellbio.nature.com ! Let's see where #CellBiology takes us this year :D

Modelling co-development between the somites and neural tube in human trunk-like structures - Nature Cell Biology Makwana, Tilley et al. generate human stem cell-based trunk-like structures approximating Carnegie stage 13–14 of development. They use them to model and study the development of the thoracic and lumb...

☕ @nmoris.bsky.social & co generate human stem cell-based trunk-like structures approximating Carnegie stage 13–14 of development. They use them to model and study the development of the thoracic and lumbar trunk.
bit.ly/3LoaXw2

Sounds about right :) happy new year!

3rd: conclusion/impact/implications
1 sentence is often enough; sometimes 2 are necessary. Provide a short, concise conclusion - what is the punchline? Do you have sth *important* to comment on regarding implications? Could be therapeutic implications or a finding that changes a dogma. Be specific.

2nd: the findings
The longest and main part of your abstract. Here you should explain:
i) what you did and how
ii) what you found
An effective abstract doesn’t bombard the reader with details; you can’t describe all your results. Stick to major.
*Must*: use friends from other fields as beta readers

1st: 1-2 (max) sentences - intro
Present the known and its caveat. It can be as brief as 1 sentence (we know x, but y (somehow linked to x) is unknown) or 2 sentences. My view is that abstracts with more than 2 introductory sentences rarely work well. Specific, clear, only the absolutely necessary.

Tip 4: Make it EASY. Avoid “empty” statements or fancy writing (that’s coming from sbd struggling with their fluffy writing habits). A good writer (in general and especially in science) does just one thing: makes sure every reader understands. Accurate, clean/short sentences, specific, **EASY**.

Tip 3: Be “conservative” (it’s the only case where I recommend it 😝). Stick to the big picture, yes, but by presenting the data that you actually have in the paper. Don’t overpromise. *Don’t present potential interpretations as results*. Don’t make a general discussion - be very specific and clear.

Tip 2: Ask yourself what you would like to read in an abstract of a study on an area that you ‘re not familiar with. The point of an abstract is not to show you have a lot of data nor present every new observation you made; it’s rather to help the reader get the major question and the major answer.

3rd: conclusion/impact/implications
1 sentence is often enough; sometimes 2 are necessary. Provide a short, concise conclusion - what is the punchline? Do you have sth *important* to comment on regarding implications? Could be therapeutic implications or a finding that changes a dogma. Be specific.

Thank you - to you, too!

🧑‍🎄I 'm far from what they call a religious person and yet I find so much joy in celebrating Christmas. I love the lights, the decorations, the family and friends gatherings. Friends, authors, reviewers, colleagues, and wonderful readers - happy holidays everyone! See you next year 🥂

Polyamines sustain epithelial regeneration in aged intestines by modulating protein homeostasis - Nature Cell Biology Minetti, Omrani et al. report that delayed intestinal regeneration results from protein homeostasis stress and can be improved by modulation of the polyamine pathway dynamics.

☕Minetti, Omrani et al. report that delayed #intestinal #regeneration results from protein homeostasis stress and can be improved by modulation of the #polyamine pathway dynamics.
bit.ly/3N38jfy

Blocking ferroptosis to expand human HSCs - Nature Cell Biology Haematopoietic stem cells (HSCs) are used in a variety of cellular therapies, but our ability to support these cells ex vivo remains technically challenging. A new study discovers that inhibiting ferr...

🍰Interested in reading more about the study? Here is the News & Views article written by @cterminiphd.bsky.social:
👉https://rdcu.be/eUZBi
bit.ly/4q7ozKQ