Mònica Sánchez-Guixé

Today, Nuria López-Bigas @nlbigas.bsky.social and Mònica Sánchez-Guixé @guixe-m.bsky.social are at the #BarcelonaBiomed Conference, organised by #IRBBarcelona.
A great occasion to share our projects related to childhood cancers.

Our recent Cancer Discovery study (Centonze et al.) shows that within hours, metastatic CRC cells switch from an EMP1⁺ invasive state to an LGR5⁺ stem-like program, highlighting that Plasticity is a dynamic, regulated cell-state decision

#Bluetorial below👇🏼

#KRAS #Plasticity #ColorectalCancer

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📣Thrilled to share our latest study just out in Cancer Discovery!

➡️
aacrjournals.org/cancerdiscov...

Is academic research becoming too competitive? Nature examines the data Applications for European research grants increased in 2025. Scientists say they’re feeling the competition.

As a researcher at the start of its career, I find this very frightening…

www.nature.com/articles/d41...

Congratulations Bet!! 🎉

📢 Thrilled to share our latest paper, KDM6 Demethylases Contribute to EWSR1::FLI1-Driven Oncogenic Reprogramming in Ewing Sarcoma, from my PhD, is now published in Cancer Research!

Explore our findings🔬🧬: aacrjournals.org/cancerres/ar...

#Epigenetics #Cancer #EwingSarcoma

Huge thanks to the team!

Sex and smoking bias in the selection of somatic mutations in human bladder - Nature Sex bias and association with smoking history identified in the landscape of driver mutations and clonal expansions in normal human bladder tissue may explain the higher bladder cancer risk in men and smokers.

🚨 New paper alert!

Sex and smoking bias in the selection of somatic mutations in human bladder

www.nature.com/articles/s41...

by @raquelbmi.bsky.social, @ferriol.bsky.social et al (in collaboration with Rosana Risques lab in @uwmedicine.bsky.social)

🧪 Out in @nature.com: Smoking and biological sex shape healthy bladder tissue evolution, offering clues to #cancer risk.

✍️ #IRBBarcelona & University of Washington

➡️ bit.ly/42wcIN5

📌 DOI: 10.1038/s41586-025-09521-x

#IRBScience #CancerResearch #BladderCancer @bbglab.bsky.social

🧵👇

📣 Youth4Kids 2025 🎗️

Let's start with @guixe-m.bsky.social from @irbbarcelona.org. Her work focuses on the origin of second malignancies in children or the factors underlying the response to immunotherapies.

Looking forward to listening to her talk!

@r4knetwork.bsky.social

Last day in the Clinical Cancer Genomics here in Amsterdam! Very nice talks and insightful views of the overall uses of genomic data in Europe. And very useful feedback in my poster on the origins of pediatric rhabodid tumors @bbglab.bsky.social #CCG2025 #CCG25

Today Mònica Sánchez-Guixé presented her talk entitled "Timing the origins of pediatric rhabdoid tumors" at the Node Seminar Series of @irbbarcelona.org
Interesting talk and interesting discussion after. It's always a pleasure to share our work.
Well done @guixe-m.bsky.social 👏👏

We’re enjoying a fantastic first day of our second Annual Meeting for the CGI-Clinics project, thanks to the organisation of @irbbarcelona.org 👏 so far we’ve heard updates on communication, tumour boards, patient empowerment and data harnessing here in beautiful Barcelona ☀️

As we are quite new in that network, we take the chance to share our research achievements of the last year.

Here you can follow a short 🧵of our latest publications:
1️⃣
www.nature.com/articles/s41...

Less than a week for registration. Check out the program: www.ccg2025.eu. With keynotes by @nlbigas.bsky.social and @charlesswanton.bsky.social and exciting sessions on clinical implementation and impact, research insights and future developments around cancer whole genome sequencing
#ccg2025

📢 We're hiring!

🟠Postdoc Fellows Stefanie Wculek, Patrick Aloy, @batllelab.bsky.social
🟠Research Assistant/Bioinformatician @bbglab.bsky.social 
🟠Public Procurement Officer
🟠Academic Officer
🟠Program Secretary

➡️ bit.ly/3MR4wO8

🧪

Congratulations David!! 🤗🤗

OpenVariant: a toolkit to parse and operate multiple input file formats AbstractSummary. Advances in high-throughput DNA sequencing technologies and decreasing costs have fueled the identification of small genetic variants (suc

🎉 I'm thrilled to announce that OpenVariant is finally published! A comprehensive toolkit to facilitate reading, parsing and refinement of diverse input file formats in a customizable structure, all within a single process. @bbglab.bsky.social at @irbbarcelona.bsky.social

doi.org/10.1093/bioi...

🧪🧬Interested in pediatric cancer genomics? Check out my last work on the origins of second malignancies in children 👇

Women are under-represented at senior levels in #academia globally, & across all #science 🧪 disciplines, as shown by these "scissor-shaped curves" ✂️

So how can we ever achieve #gender #equality?

We discuss various strategies in this #Cell Commentary

#WomeninSTEM

www.cell.com/cell/fulltex...
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Improving cancer genome interpretation for precision medicine in oncology - CGI-Clinics

CGI-Clinics project just joined Bluesky.

Follow it to stay tuned on exciting updates coming soon about the project

👉 @cgiclinics.bsky.social

cgiclinics.eu

We recently announced a dual new release of intOGen and boostDM

Computational analysis of 33,218 tumor genomes to identify cancer genes and driver mutations

➡️ Compendium of Cancer Driver Genes - www.intogen.org

➡️ In Silico Saturation Mutagenesis of Cancer Genes - www.intogen.org/boostdm

Children who develop two independent tumors during childhood are extremely rare

We wanted to see if our genomic technologies could shed light into those exceptional cases.

Read about it in this recent paper:
tinyurl.com/yt9m584d

I've started a list of people working on #cancer #evolution. Many more to be added, so do let me know if that is you. Also if you would like to be removed. go.bsky.app/QuAF4Mo

Hi everyone! Glad to see that science bluesky is growing so rapidly :)
My research focuses on pediatric cancer, genomics, and tumor evolution. Follow me if interested! 🧪🧬

Hi Trevor! Could you add me as well? Thanks a lot!

Pls share 🌟Join the IMP as a Group Leader
We are 👀 for a colleague, ready to lead a groundbreaking research program. Enjoy generous funding, outstanding facilities & a vibrant scientific community in one of the world's most livable cities @impvienna.bsky.social
👉https://tinyurl.com/impgl2025

Are you a #postdoc with an innovative vision for starting your own lab in #Syntheticbiology, #Genomics, #GeneRegulation, #Development, #Cancer, #Immunology or #InfectionBiology?

@IMPvienna is inviting applications for group leader positions: www.imp.ac.at/career/open-...

Pls share!

I’ve started making a starter pack for computational #cancer! Let me know if you’d like to be added or know someone who should be go.bsky.app/N6moBmG

Hi! Could you add me? Thanks!

Here's the #Cancer #Research #2 starter pack 🤩

Researchers, oncologists, patient advocates & more -working across all aspects of cancer research and treatment 🧪🔬⚕️

I also tried to give some exposure to #PhD #students & #postdocs - randomly picked from followers of me or my lab!

go.bsky.app/6EcjWNA