Bede Portz

Game is amazing just stop mumbling

Eric those days are long over and I’m sorry

Smoltz is a terrible announcer

Haven’t seen a rolo or watchamacallit in ten years

Butterfingers will be next if the payday and hundred grand are critically endangered then butterfingers are a threatened species

They dont give kids 100 grands or payday anymore we used to be a real country @triggerloop.bsky.social

Selective RNA sequestration in biomolecular condensates directs cell fate transitions - Nature Biotechnology Stem cell differentiation is controlled by manipulating RNA condensates.

1/ Excited to share our new study with @brumbaugh-lab.bsky.social, out in @natbiotech.nature.com! P-bodies selectively sequester RNAs encoding cell fate regulators, often from the preceding developmental stage. Releasing these RNAs can drive changes in cell identity. 🧵 www.nature.com/articles/s41...

We should catch up I think about you often and how you are doing

Abstract B105: Oral small molecule MYC condensate modulators (c-mods) induce robust anti-tumor responses in preclinical solid tumor models aacrjournals.org/mct/article/24… From my Dewpoint era. I lead this program from ideation to late lead optimization. I hope it advances to the clinic.

the Muppets have been real quiet since the Louvre heist

Zinc finger domains bind low-complexity domain polymers - Nature Communications Self-association of low-complexity protein sequences (LC domains) is important for polymer formation, but the mechanisms underlying cell recognition of LC domain polymers remain unclear. Here, authors...

www.nature.com/articles/s41...

Multi-immersion Oblique Plane Microscope (miOPM): A reconfigurable platform for high-resolution Light-Sheet Fluorescence Microscopy Light-Sheet Fluorescence Microscopy (LSFM) enables gentle, rapid, and efficient volumetric imaging of biological specimens. Despite its potential, LSFM has fragmented into multiple variants, each narr...

From @retof.bsky.social @kevin-dean.bsky.social et al. As a big proponent of image-based high throughput phenotypic screening and AI-enabled hit calling this looks really cool www.biorxiv.org/content/10.1...

Synthetic non-canonical amino acids or gtfo

UT Southwestern researcher receives NIH Director’s New Innovator Award David Sanders, Ph.D., Assistant Professor in the Center for Alzheimer’s and Neurodegenerative Diseases and Molecular Biology at UT Southwestern Medical Center, has been awarded $2.4 million over five ...

Humbled to announce that we received a New Innovator award. I thank the NIH’s civil servants for their hard work during a stressful funding cycle. I thank the leadership (and chair, Marc Diamond) at UTSW for betting on my lab’s high risk, high reward research. www.utsouthwestern.edu/newsroom/art...

This is so obvious in hindsight yet I hadn’t considered the evolutionary pressure against lysines in this context. Do you know if WNK ( with no lysine) family kinases are involved in regulating quality control?

A strong quality for a good researcher is the ability to sometimes ignore small details, and sometimes delves into them with the greatest care, and more importantly to being able to switch wisely between the two modes.

Harrison Bader battling through injury he got facing Nitro in the joust. #GoPhils #Phillies #americangladiator

Extrachromosomal DNA associates with nuclear condensates and reorganizes chromatin structures to enhance oncogenic transcription Extrachromosomal, circular DNA (ecDNA) is a prevalent oncogenic alteration in cancer genomes, often associated with aggressive tumor behavior and poor…

www.sciencedirect.com/science/arti...

Cute young at heart couple earring race medals from a 5K charity run/walk on a sunny day in Pittsburgh

Happy to participate in Pittsburgh SCADaddle 5K for SCAD research. SCAD is the kind of heart attack that mostly affects healthy women >40 without traditional risk factors. Can be associated with peri or postpartum and commonly SCAD patients also suffer migraines @scadalliance.bsky.social

Turned this game on against my better judgement only to see PSU mismanage (charitable) the clock and bungle the play calling, Allar to take the most Allar sack, and for us to give ball to UCLA to score. All while announcers excoriate us.

Wow please tell me that was also a deliberate reference to Taylor Swift's new album too

Translation landscape of stress granules Cryo–electron tomography visualizes stress granules in situ, revealing their spatial interplay with translation machinery.

Translation landscape of stress granules | Science Advances

www.science.org/doi/10.1126/...

wait you can actually make outlook worse?

My rock climbing gym has paper copies of Cell and Neuron, and I ran into a buddy there working on a drug discovery paper while his kid climbed. #Boston #NorthShore

ATP-dependent remodeling of chromatin condensates reveals distinct mesoscale outcomes Adenosine triphosphate (ATP)–dependent chromatin remodeling enzymes mobilize nucleosomes, but how such mobilization affects chromatin condensation is unclear. We investigate effects of two major remod...

Today I am so pleased to present our work on how chromatin remodelers affect mesoscale chromatin organization.
www.science.org/doi/10.1126/...

Also needs to be said that (as some folks know) our software packages are named after birds, so while I was away, the lab filled my office with birds... ...but honestly... *very* tastefully.

Will stay for the foreseeable future!

If we take just a lil bit of Tylenol or maybe make a slightly less potent analog would that be like a vaccine that prevents autism?

Area man who looks like he is in pixies has never heard pixies more at 11

Will read. Relationship to development of serous ovarian cancers?

Still trying to figure out what MAHA hates more: women or vaccines.