Bede Portz

NELF prevents transcriptional readthrough into DNA replication zones in cancer cells - EMBO Reports Regulation of RNA polymerase II (Pol II) transcription is closely associated with cell proliferation. However, it remains unclear how the Pol II transcription program is rewired in cancer to promote u...

Extremely happy to share our latest research on the NELF complex in @emboreports.org done in collaboration with the groups of Dr Takayuki Nojima and Dr Yasukazu Daigaku in Japan.

link.springer.com/article/10.1...

It is also so cheap and easy now
to just buy whatever constructs you need that is the safest bet

A lesson I learned the very hard way in 2008 after making a transgenic fly line in Dave’s lab.

There are still a few more hours left in today any more papers uo your sleeve?

Pleased to share the final version of this behemoth of a paper, now finally published. I guess I can retire now?
www.nature.com/articles/s41...

More functional data, many thousands of words removed, and a few other updates from last year's preprint.

Papers are like buses... You wait for ages, then two come along at once.

Huge congrats to @bornanovak.bsky.social and @jefflotthammer.bsky.social for pushing and driving every aspect of this work, preprinted ~1 year ago to the day (Friday before BPS), now published!

www.nature.com/articles/s41...

I think there was a lot of pressure here to get this to happen. The review needs to be fair and under tremendous scrutiny

Lutnick Acknowledges Traveling to Epstein’s Island

Lutnick Acknowledges Traveling to Epstein’s Island www.nytimes.com/2026/02/10/u...

CU Anschutz Recruits National Leader to Launch Functional Personalized Medicine Initiative CU Anschutz welcomes Alice Soragni to launch a Functional Personalized Medicine Initiative using rapid tumor organoid testing to guide treatment decisions.

Happy to share this new, very intentional chapter. I have left UCLA after 14 years to join the University of Colorado Anschutz as Professor of Biomedical Informatics and Neurosurgery and the inaugural Marsico Chair in Excellence in Functional Precision Medicine/n

news.cuanschutz.edu/dbmi/cu-ansc...

Budweiser and Bad Bunny are tied 💯 to 💯 in the Super Bowl.

www.biorxiv.org/content/10.6...

www.nature.com/articles/s41...

Too soon.

www.biorxiv.org/content/10.6...

Can’t think of a better thing for my kids to see than their mom and her girlfriends singing the late gen X/elder millennial woman’s cannon. Currently, ‘Like a prayer.’

Crazy we got like 23” of fascism last week and we might get even more tomorrow. Snow. I mean snow.

The sequence context of RG/RGG motifs determines condensate formation, transportin-1 binding and chaperoning www.biorxiv.org/content/10.6...

Dear Catholics who have drifted: The church needs us in the battle for our nation’s soul. Those who have “drifted” but still value the teachings that shaped us need to start being the body of Christ we wish to see.

www.americamagazine.org/faithinfocus...

Metabolically regulated proteasome supramolecular organization in situ Structural steps along the assembly of proteasome storage granules—membraneless organelles that form in response to metabolic shifts in yeast—are visualized inside cells by cryo-electron tomography. Inactive 26S proteasomes oligomerize into trimers, which assemble into paracrystalline arrays that serve as reservoirs of fully assembled proteasomes under conditions of low energy, ready for reactivation when glucose is restored.

Now online! Metabolically regulated proteasome supramolecular organization in situ

I guess they are saying we can only exercise one unalienable right at a time now? That the Bill of Rights is a menu, and we can pick only one?

My sister-in-law's dad died last week, in hospice in the VA hospital in Minneapolis. I just learned Alex Pretti was part of his care team. They shot Alex less than 1/2 mile from my niece's house while doing the same observation work that my niece is doing. These are real people. Step up folks!

Ugh

Progress and challenges in profiling protein-RNA and protein-associated RNA-RNA interactions - PubMed RNA binding proteins (RBPs) play essential roles in post-transcriptional gene regulation by interacting with a wide range of RNA targets. In addition to regulating RNA processing via individual RBP-RNA interactions, there is a growing appreciation of the regulatory impact of protein-associated RNA-R …

Happy to share Joey (Zhuoyi)'s review on technologies to map RBP:RNA and (especially) RBP-associated RNA:RNA interactions is now up at RNA! pubmed.ncbi.nlm.nih.gov/41535089

a mascot for the philadelphia eagles is standing in front of some fireworks boxes ALT: a mascot for the philadelphia eagles is standing in front of some fireworks boxes

Go birds!

It’s terrible

You are maturing and softening. That is 29 minutes longer than you ever celebrated anything previously.

Do cigarettes too

Molecular basis for thermoresponsive protein condensation in plants Plants continuously experience temperature fluctuations that shape their physiology, development, and survival. Yet, how plants sense and adapt to elevated temperatures at the molecular level remains ...

www.biorxiv.org/content/10.6...

I want to pay (out of pocket) for an improved LLM over free ChatGPT. What model is the best for summarizing biology and biomedical literature, iterating on hypotheses, bioinformatics vibe coding, etc?

This vaccine shows strong signal for reducing or delaying dementia! And who wants to get shingles? Get this vaccine!