Nima Sharifi MD

Androgen Metabolism in Prostate Cancer: Recent Advances Abstract. Androgen biosynthesis is physiologically necessary for generating the principal stimulus for androgen receptor (AR) signaling and thus plays an e

Androgen Metabolism in Prostate Cancer: Recent Advances #metabolism #testosterone #prostatecancer url: academic.oup.com/endo/article...

Metabolomic Insights Into Saliva as a Non‐Invasive Surrogate for Serum to Enable Community‐Based Biomarker Investigation Introduction Using serum metabolomics in Community-Based Participatory Research (CBPR) with underserved populations presents challenges due to the invasive nature of venipuncture, which limits longi...

onlinelibrary.wiley.com/doi/10.1002/...

Crows! They left a mystical feeling flying overhead in a rush. @carlbergstrom.com

Just 1 more week to go until the 3rd Miami Symposium on Human Metabolism. Register today! In addition to the speaker lineup, the poster titles are presenters are now up👇! 🧪 med.miami.edu/elp/miamimetab…

Research Associate 1 in Miami, Florida, United States of America | Research at University of Miami Apply for Research Associate 1 job with University of Miami in Miami, Florida, United States of America. Research at University of Miami

We are looking for a research associate with a working knowledge and interest in mass spectrometry of small molecules. If interested, please check this out! careers.miami.edu/us/en/job/R1...

The flock at dusk

Congratulations @zhipengawang.bsky.social and team! What an incredible discovery in #metabolism and protein modification! It turns out acetoacetate is converted to another metabolite that modifies cysteines! 🧪

Are you a postdoc or PhD student? Working on #metabolism?

Escape the snow, apply for a travel award & submit an abstract for the 3rd #Miami Symposium on Human Metabolism on February 14, 2026! 🧪

The deadline is 12/31!

Submit here: med.miami.edu/elp/miamimet...

Very excited our story on a CYP17A1-independent androgen biosynthesis pathway is out! Could explain why androgens are left when we use abiraterone to block CYP17A1 clinically in prostate cancer. Need to look more closely at oxidized forms of cholesterol! Please read the whole paper. 🧪 rdcu.be/eS7kU

NUDT5 regulates purine metabolism and thiopurine sensitivity by interacting with PPAT Cells generate purine nucleotides through de novo purine biosynthesis (DNPB) and purine salvage. Purine salvage represses DNPB to prevent excessive purine nucleotide synthesis through mechanisms that ...

1/New paper from Zheng Wu, Phong Nguyen et al. @cri-utsw.bsky.social shows how cells balance the two pathways that produce purine nucleotides: de novo purine biosynthesis (DNPB) and purine salvage. The surprising mechanism involves NUDT5, a Nudix hydrolase

www.science.org/doi/10.1126/...

True words!

Living in the Present Tense | NEJM When a pediatrician caring for patients with a rare genetic disease discovers incidentally that he carries his own rare high-risk mutation, he must learn from a patient’s parents how to shift his p...

www.nejm.org/doi/full/10....

Big and well deserved congratulations to @zhipengawang.bsky.social for his new Prostate Cancer Foundation Young Investigator Award! So well deserved! He is doing incredible work discovering new mechanisms of ketones in metabolism. And congrats to all the other PCF young investigator awardees! 🧪

Evidence that even when LLMs produce similar results to humans, they “rely on lexical associations and statistical priors rather than contextual reasoning or normative criteria. We term this divergence epistemia: the illusion of knowledge emerging when surface plausibility replaces verification”

Latest clinical data on HSD3B1 presented at ASTRO www.urotoday.com/conference-h...

Opinion | How the Manosphere Hijacks Young Men’s Interest in Science

"Rockets, computers and lifesaving medicines all come from decades of effort by scientists hunkered over pages of calculation or the laboratory bench. They required the same tireless, single-minded effort every elite athlete understands." 🧪 @adamfrank4.bsky.social www.nytimes.com/2025/10/03/o...

Faculty – Assistant, Associate and Full Professor - Miami, Florida (US) job with Miami Miller School of Medicine - Desai Sethi Urology and Sylvester Comprehensive Cancer Center | 675109 The Desai Sethi Urology Institute seeks scientists to study genitourinary cancers, offering strong support, collaboration, and a new cancer facility.

We are hiring and looking for exceptional faculty! If you are interested in the fundamental mechanisms of human biology, biochemistry, metabolism, or genetics, please look here! 🧪 jobs.sciencecareers.org/job/675109/f...

A Trailblazing Geneticist Reflects On Her Life And Work Dr. Mary-Claire King was the first to link a gene to hereditary cancer risk with the identification of BRCA1. She was just getting started.

Today, scientists know that genetics plays a role in many conditions and diseases. But back in the ’90s, geneticist Mary-Claire King was the first to link a gene to an inherited form of a common cancer.

These pelicans out this morning are just magnificent and mesmerizing to watch

Reduced Screening May Have Led to Rise in Advanced Prostate Cancer Diagnoses

Reduced Screening May Have Led to Rise in Advanced Prostate Cancer Diagnoses www.nytimes.com/2025/09/02/s...

Congratulations @marinaparry.bsky.social! Wonderful work!

Enjoyed working with Masoud Bitaraf and Elena Castro on this review on prostate cancer germline variants with therapeutic implications for Trends in Molecular Medicine! 🧪 #UroSky #MedSky @cp-trendsmolecmed.bsky.social authors.elsevier.com/a/1lWYz5Eb1B...

Congrats to you and your team, Ralph! @rjdlab.bsky.social

Such an honor and so much fun to join the Cancer Clear and Simple @uwhealth.bsky.social Carbone Cancer Center Podcast to discuss liquid biopsies in cancer!

cancer.wisc.edu/community-ou...

I consider myself fortunate for every day I can continue to do science

An Editor's Pick paper at J Biol Chem @asbmb.bsky.social! Don't forget to read the profile about the first author Xiuxiu Li at the end of our paper on HSD3B1 and breast cancer! Dr. Li recently moved from University of Miami to the University of Alabama! 🧪 www.sciencedirect.com/science/arti...