📑 New study! Why would cells invest in a protein that degrades within minutes? TRIM52 is one of the most unstable proteins in the human proteome. Research by @versteegga.bsky.social in Nature Communications reveals its advantageous role ➡️ tinyurl.com/yw6wtzkc
@univie.ac.at
@meduniwien.ac.at
29.04.2025 13:04 — 👍 13 🔁 4 💬 0 📌 0
Huge thank you to our collaborators, Ameres @ameressl.bsky.social and Versteeg labs, for their essential input, insights, and support!
07.04.2025 19:57 — 👍 1 🔁 0 💬 0 📌 0
6/ 📜 Check out the full study for details!
www.biorxiv.org/content/10.1...
@gekaragoz.bsky.social @maxperutzlabs.bsky.social @vbcscitraining.bsky.social
#RNA #UPR #ERstress #IGF2BP3 #RBP
07.04.2025 15:15 — 👍 3 🔁 0 💬 1 📌 0
5/ 🏥 Why does this matter? The UPR is implicated in development and cancer - contexts where IGF2BP3 is highly expressed. This dual-layered regulatory mechanism may allow cells to shift between opposing IGF2BP3 functions, enabling cell state-specific fate decisions.
07.04.2025 15:13 — 👍 1 🔁 0 💬 1 📌 0
4/ 🔬 Mechanistically, we observed increased association of IGF2BP3 with the mRNA decapping complex during ER stress, which can result in enhanced degradation of IGF2BP3 targets
07.04.2025 15:13 — 👍 1 🔁 0 💬 1 📌 0
3/📉 By tracking changes in total and newly transcribed mRNAs, we show that IGF2BP3 facilitates UPR via two distinct mechanisms:
• It reduces protein folding load by destabilizing most of its target mRNAs
• It upregulates UPR effectors stabilizing mRNAs encoding select transcriptional regulators
07.04.2025 15:12 — 👍 1 🔁 0 💬 1 📌 0
2/🔬 IGF2BP3 is an RNA-binding protein known for regulating mRNA stability, particularly in development & cancer. Surprisingly, under ER stress, IGF2BP3 binds key UPR effector transcripts including XBP1, HSPA5, and DDIT3 (CHOP) —major regulators of ER stress adaptation & apoptosis
07.04.2025 15:10 — 👍 1 🔁 0 💬 1 📌 0
1/ Thrilled to share the core of my PhD project—just posted on BioRxiv!🚨 We uncover a novel role for IGF2BP3 in regulating the cellular response to the endoplasmic reticulum (ER) stress – the unfolded protein response (UPR). Thread 🧵 (1/6) ⬇️
www.biorxiv.org/content/10.1...
07.04.2025 15:09 — 👍 34 🔁 8 💬 2 📌 2
Bioinformatics Scientist / Next Generation Sequencing, Single Cell and Spatial Biology, Next Generation Proteomics, Liquid Biopsy, SynBio, Compute Acceleration in biotech // http://albertvilella.substack.com
cryo EM enthusiasts with interest in molecular machines.
PhD student in the Haselbach lab (IMP, Vienna). Visualizing proteins and cells by shooting charged particles at them.
Group leader at the Hubrecht Institute, fascinated by tissue regeneration. Studies the axolotl, a vertebrate capable of regenerating entire limbs after injury, and uses the principles learnt to build 3D tissues in vitro. 🇳🇱🇦🇹🇬🇧🇯🇵
Fan of dark DNA&RNA, transposons, embryology, 3D genome, big and small adventures
Group Leader at IMBA, Vienna Biocenter
Group leader at IMBA Vienna | Excited about #devbio #synbio #stemcells #patterning #morphogenesis #metabolicsignalling #energetics | Investigating how metabolism shapes development
https://www.oeaw.ac.at/imba/groups/kristina-stapornwongkul
Associate Professor @MedicineUVA
Studying one of the most challenging questions of biology “Why does biological aging occur?”
RNA-binding proteins in cancer group, led by Fátima Gebauer. Working at the CRG, Barcelona.
RNA Biology, Computing, Heavy music, Videogames, and other horrible things.
MSc:
Unipisa
PhD:
MDC_Berlin
Postdoc:
UCSF
First supporter of the
Calviello Lab https://humantechnopole.it/en/research-groups/calviello-group/
Systems biologist • Prof at Max Perutz Labs & MedUni Vienna • dad×2 • he/him
#LoveVirology #TeamMassSpec #dataviz
📍 Vienna 🇪🇺
Cell biologist excited about autophagy, quality control, evolution, and membrane trafficking. Reads and thinks about academic mentoring, equality & diversity. https://www.cos.uni-heidelberg.de/en/evolutionary-cell-biology
The Max Perutz Labs are a joint venture of the University of Vienna and the Medical University of Vienna, dedicated to a mechanistic understanding of fundamental biomedical processes.
Molecular Biologist, Transcription enthusiast and stem cell afficionado
Associate Professor at Max Perutz Labs and University Vienna,
Professor of RNA Biology @University of Vienna, Groupleader @MaxPerutzLabs studying post-transcriptional gene regulation in flies and mammals @viennabiocenter
Research, Education and Business. Vienna BioCenter is a life science cluster that includes IMP, IMBA, GMI, Max Perutz Labs, as well as the Faculty of Life Science & CeMESS (both University of Vienna) and 35+ biotechs.
FWF-funded Austrian Research Consortium of the labs of Sascha Martens, Alwin Köhler, Andreas Bachmair, Gijs Versteeg, Tim Clausen, David Haselbach, Yasin Dagdas, Silvia Ramundo, Georg Winter, Christian Becker & Ilaria Piazza. www.protein-degradation.org
🏳️🌈 Assoc. Prof @Max Perutz Labs Vienna, Biochemist & Structural Biologist, #RNA & #protein, Tennis addict, 🐈❤️,all time skeptic 🤨
Biologist and proteomics specialist at Max Perutz Labs Vienna.
Sendoel lab at the University of Zurich, alumnus of the The Rockefeller University, NYC.
We are excited about mRNA translation, stem cells and cancer.
www.sendoellab.org
Biochemist and cell biologist working on autophagy at the Max Perutz Labs, University of Vienna
