Burkard Lab

We’re excited to share a Postdoc Opening in the Burkard Lab @iowa /Holden Cancer Center. The fellow will study mitotic regulation in normal & cancer cells, exploring drug response & resistance in human samples, organoids, & preclinical models. Spread the word!
📅 Apply by 3/1/26
📧 mburkard@uiowa.edu

Want better resolution of small chromatin / subnuclear structures? Our new method, One-step 4× and 12× 3D-ExM, improves super-resolution microscopy in both 2D and 3D cell culture. Useful for labs studying kinetochores, nuclear pores, chromosomes, etc. #methods #microscopy #cellbiology

The reckoning of chromosomal instability: past, present, future - Chromosome Research Quantitative measures of CIN are crucial to our understanding of its role in cancer. Technological advances have changed the way CIN is quantified, offering increased accuracy and insight. Here, we re...

Chromosomal instability is everywhere in cancer biology—but how do we actually measure it?
Our 2024 review The Reckoning of CIN: Past, Present, Future (Lynch, Bradford, Burkard et al.) digs into the methods, pitfalls, and what’s coming next. #CIN #Aneuploidy #CancerBiology

Measuring chromosomal instability #CIN isn’t straightforward. We compared live imaging, FISH, scDNA-seq & other assays, and found significant differences. Our take: Use mis-segregations per diploid division (MDD) as a clear standard.
www.pnas.org/doi/10.1073/...

👋 Welcome to the Burkard Lab!
We study how errors in mitosis cause chromosomal instability and aneuploidy.
Our projects span mitotic regulators like PLK1 as well as how aneuploidy shapes cancer and cell fitness.
Follow us for research updates and lab life at Iowa!

We’re excited to share a Postdoc Opening in the Burkard Lab @iowa /Holden Cancer Center. The fellow will study mitotic regulation in normal & cancer cells, exploring drug response & resistance in human samples, organoids, & preclinical models. Spread the word!
📅 Apply by 3/1/26
📧 mburkard@uiowa.edu

Thank you! Would you please add us to the list too?

Measuring chromosomal instability #CIN isn’t straightforward. We compared live imaging, FISH, scDNA-seq & other assays, and found significant differences. Our take: Use mis-segregations per diploid division (MDD) as a clear standard.
www.pnas.org/doi/10.1073/...

The reckoning of chromosomal instability: past, present, future - Chromosome Research Quantitative measures of CIN are crucial to our understanding of its role in cancer. Technological advances have changed the way CIN is quantified, offering increased accuracy and insight. Here, we re...

Chromosomal instability is everywhere in cancer biology—but how do we actually measure it?
Our 2024 review The Reckoning of CIN: Past, Present, Future (Lynch, Bradford, Burkard et al.) digs into the methods, pitfalls, and what’s coming next. #CIN #Aneuploidy #CancerBiology

Want better resolution of small chromatin / subnuclear structures? Our new method, One-step 4× and 12× 3D-ExM, improves super-resolution microscopy in both 2D and 3D cell culture. Useful for labs studying kinetochores, nuclear pores, chromosomes, etc. #methods #microscopy #cellbiology

Polo-like kinase 1 maintains transcription and chromosomal accessibility during mitosis | Molecular Biology of the Cell Transcription persists at low levels in mitotic cells and plays essential roles in mitotic fidelity and chromosomal dynamics. However, the detailed regulatory network of mitotic transcription remains ...

New from the Burkard Lab: Polo-like kinase 1 maintains transcription & chromosomal accessibility during mitosis.We show PLK1 is vital not just for mitotic machinery but for keeping promoter/TSS regions accessible & transcription active. Check it out www.molbiolcell.org/doi/10.1091/... #mitosis #plk1

Thank you Adrian for leading this, would you add our lab to the pack as well. Appreciate it.

Thank you for creating and leading this pack! We would like to join. :)

Hi! We would like to join the Cancer Bio Starter pack . Thank you for leading and creating this!

👋 Welcome to the Burkard Lab!
We study how errors in mitosis cause chromosomal instability and aneuploidy.
Our projects span mitotic regulators like PLK1 as well as how aneuploidy shapes cancer and cell fitness.
Follow us for research updates and lab life at Iowa!

Dear Andre, would you please add our lab to your starter pack? Much appreciated.

Dear Adrian, would you please add our lab to your Aneuploidy and Chromosomal Instability and Cell Cycle and Senescence starter list? Much appreciated it!