Tanner O Monroe

I can’t possibly agree with this more. Clinical trials agnostic to genetic risk is costing lives. We desperately need to be more mindful about whom to include and why

I am hiring at all levels! Please share this ad with anyone you think might be interested. I have many ideas and few hands. www.linkedin.com/jobs/view/43...

even worse - disproven

Thanks! Just a modest amount of paperwork before we are rolling 👍

Nice view of a court out there. Would be a shame if a new assistant professor hustled a few locals on it.

(ER just out of frame in the more likely PI injury scenario)

Monroe Lab for Experimental Cardiogenomics is open! Ready to fill it up and make some discoveries.

See my pinned thread. Happy to have this version out!

A combined genomic arrhythmia propensity score delineates cumulative risk Monroe et al. analyze genome sequencing from individuals with early-onset ventricular arrhythmias. Combining the effect of common genetic variants with rare coding and noncoding regulatory variants in cardiomyopathy and arrhythmia genes predicts outcomes. Each component additively predicts arrhythmia with the cumulative GAPS performing best.

Online now: A combined genomic arrhythmia propensity score delineates cumulative risk

Expect this and more coming from the Monroe Laboratory for eXperimental CardioGenomics opening Jan '26! More details soon..

A simple idea we hope can be extended to other complex traits - we added together three layers of genetic risk for non-ischemic arrhythmia: high effect coding variants, regulatory elements mapping to them, and common variants thought to influence cardiac form and function.

Find this and more coming from the Monroe Laboratory for eXperimental CardioGenomics!... more details coming soon

A combined genomic arrhythmia propensity score delineates cumulative risk Monroe et al. analyze genome sequencing from individuals with early-onset ventricular arrhythmias. Combining the effect of common genetic variants with rare coding and noncoding regulatory variants in...

Busy weekend at AHA, but I am happy to report our genomic arrhythmia risk paper is now online!

www.cell.com/cell-reports...

See you ❤️ people in New Orleans. Check out the sessions I am helping moderate on 11/10, and find me to chat about some not-quite-public Monroe lab news😊:

Gene Therapy: Repair the Heart by Targeting its Genes 9:45AM

Science-NIH Forum: Aligning CV Research and Funding Priorities 3:15PM

Great week among the madness!

1. Genomic Arrhythmia Propensity Score (GAPS) paper accepted in principle.

2. Awarded the 2025 CDDRC Fellowship!

3. Shot 70 (-2) on Saturday 🤣⛳

Honored that @jclinical-invest.bsky.social invited me to provide some additional context for this innovative work by @bloodgenes.bsky.social

See you ALL at Weinstein tomorrow. Catch my talk on Thursday when I describe how we found evidence for noncoding variation contributing to ventricular arrhythmia/sudden cardiac arrest.

Prominent critics - geneticists who dedicate their lives to understanding the minutiae. Prominent proponents - "tech elite" who fall for every trending health supplement and podcaster gimmick. 🤷. Maybe they'll pay me to stock the embryo warehouse shelves at least! Great to see the topic highlighted

His iconoclasm is exactly why a photo of Dylan at the Newport Folk Festival sits above my desk next to Radiant Baby.

You WNT2 far with this one 😬.

Honestly, it’s the LATS thing I wanna talk about tonight.

Hippo keeps surprising us! Wait…

What an absolute embarrassment.

a man wearing a hat that says wayne 's world smiles ALT: a man wearing a hat that says wayne 's world smiles

Looking forward to sharing some of my latest work at @weinsteinconf.bsky.social 2025! Of course, in addition to us, Milwaukee (the good land) has certainly had its share of visitors. It is also the only major American city to have ever elected three socialist mayors.

Repurposing of a gill gene regulatory program for outer-ear evolution - Nature A study on the evolutionary origin of the mammalian outer ear finds that it shares genetic programs with the gills of fishes and amphibians, indicating that elements of an ancestral gill have been reu...

Can you hear it? We are all fish! Shouts to Dr. Gillis for helping to gill us. Terrific work. www.nature.com/articles/s41...

Deciphering the digenic architecture of congenital heart disease using trio exome sequencing data Congenital heart disease (CHD) is the most common congenital anomaly. With a molecular diagnosis rate of 55% and high genetic heterogeneity, investigating non-monogenic causes of CHD is warranted. Thi...

"These findings contribute to our understanding of the genetic complexity underlying CHD pathogenesis and emphasize the importance of investigating digenic interactions in other complex disorders." I concur. www.cell.com/ajhg/fulltex...

Advances in the study and treatment of genetic cardiomyopathies Research on the molecular genetic basis for cardiomyopathies, primary heart muscle disorders, has made significant progress in the past decades. This article reviews current understanding of the genet...

" However, too many patients remain gene-elusive, due to failure to employ comprehensive genetic diagnosis and limited insights into polygenic risk across diverse populations. "

-stay tuned for my take on this problem hopefully out soon 😀

www.cell.com/cell/fulltex...

My big question re health and health research funding in the last few weeks is “why?” It makes no sense either politically, historically, or morally.

the yield on NIH research for economic activity

How to get 146% return on investment?
The NIH. That's just the economic benefit.
Biomedical research promotes human health.

It’s happening. Be prepared!