Oliver Barnstedt

🧠 How do emotion and memory shape behavior?
Join live webinar with Dr. Oliver Barnstedt @obarnstedt.bsky.social l & Dr. Anne Petzold @neuroadept.bsky.social(European Neuroscience Institute Göttingen)
🗓️ November 13th | 14:00 CET
👉 Clickto register: us02web.zoom.us/webinar/regi...

PSD-95 drives binocular vision maturation critical for predation Postsynaptic density protein 95 (PSD-95) is a signalling scaffold within the postsynaptic density of excitatory synapses which drives silent synapse maturation during critical periods (CP). Binoculari...

Another big piece of work from our lab is out on bioRxiv. Learn about the role of PSD-95 for hunting behavior in mice here: www.biorxiv.org/content/10.1...

One more week left to apply for this 4-year full-time TECHNICAL ASSISTANT position at the EUROPEAN NEUROSCIENCE INSTITUTE GÖTTINGEN!

Congrats to lead authors @alexattinger.bsky.social and Tony Drinnenberg and all our amazing collaborators! Check out the thread below for new work from the lab on plasticity, cortex and spatial representations for navigation!

Cross-species implementation of an innate courtship behavior by manipulation of the sex-determinant gene In accepting a courting male, Drosophila subobscura females require nuptial gift giving in which a male gives regurgitated crop contents to her mouth to mouth. No similar behavior is found in D. melan...

doi.org/10.1126/scie...

This seems rad: overexpressing FruM in a set of proboscis-motorneuron-projecting neurons makes melanogaster males add food-sharing to their courtship repertoire.

It is fascinating to see evolutionary shifts in behavior be tied so concretely to shifts in brain development!

The connectome of the entire male Drosophila central nervous system is out!! Acquired using FIB-SEM @ 8x8x8nm, we aligned 7.5 mio 2D images aligned into one seamless 3D volume, which was used to segment & proofread neurons and synapses. @hhmijanelia.bsky.social

www.biorxiv.org/content/10.1...

Our lab at the European Neuroscience Institute in Göttingen is looking for a highly skilled and motivated TECHNICAL ASSISTANT. Are you proficient in histological and wet lab techniques and lab management? Then come apply for our position (4 years contract)! umg.recruiting-portal.com/r/z004xflh7r...

Happy to share that I just started a W2 professorship at the University of Bremen! Yay tenure! While I already start teaching now, the lab will stay in Freiburg until May while we get things ready. Super excited about this new chapter! We’re also hiring! Please get in touch if you’re interested!

I’m pleased to share our new paper, “Hippocampal ripple diversity organizes neuronal reactivation dynamics in the offline brain”, out in @cp-neuron.bsky.social !

With @vitorlds.bsky.social and David Dupret, we show that diversity in ripple current profiles shapes reactivation dynamics

Thanks to the @linmagdeburg.bsky.social and its great research community for all the fantastic support along my scientific journey! Looking forward to the conference www.lin-magdeburg.de/institut/lea... in 24 days!

Photograph shows Dr Anggi Hapsari in an image from her own collection.

Photo shows Dr Oliver Barnstedt with thanks to Leibniz-Institut für Neurobiologie / Robin Ritter for this image.

Congratulations Dr Anggi Hapsari and Dr Oliver Barnstedt at our Campus on their new ERC Starting Grants!

Good luck with #ERCStG research #SaLtedPeat and #LearnMamBo! Find out more: www.uni-goettingen.de/en/3240.html...

#Ecology #UniGoettingen & #Neuroscience #MBExC #UMG Thanks to @erc.europa.eu

a man wearing a hat and a suit says mambo no. 5 . ALT: a man wearing a hat and a suit says mambo no. 5 .

We are super excited that our project ***LearnMamBo*** Neuronal Dynamics of Learning and Memory in the Mammillary Body gets an #ercstartinggrant @erc.europa.eu – we will dissect the associated circuits supporting episodic memory – REACH OUT if interested in joining this project!

Do we understand how neural networks work? Yes and no.

There is some confusion about whether or not we understand LLMs. The answer is yes and no, but mostly no. It's a complicated enough question that it seemed like it needed an article.

www.verysane.ai/p/do-we-unde...

Why We Still Need Animal Research in a World of AI and Organoids The portrayal of uncaring scientists without any thought for the animals being used in their research is far from the truth.

www.genengnews.com/topics/trans...

🚨🚨My PhD work pre-print🚨🚨
Check it out 👇👇
'Avoidance engages dopaminergic punishment in Drosophila'

It's a great collaborative enterprise and can't thank enough to my mentors and collaborators for the kindest efforts...fingers crossed 🤞🤞

A mouse brain stereotaxic topographic atlas with isotropic 1-μm resolution - Nature A stereotaxic atlas of the whole mouse brain, based on a Nissl-stained cytoarchitecture dataset with isotropic 1-μm resolution, achieved through continuous micro-optical sectioning tomography, promise...

www.nature.com/articles/s41...

@guidomeijer.com has #neuropixels preprocessing worked out for you!

Congrats, Mari! Nice to see this out in its full glory now! 🎉🎉🎉

A flexible hippocampal population code for experience relative to reward - Nature Neuroscience Sosa et al. find that hippocampal neural activity in mice encodes both environmental location and experience relative to rewards, spanning distances far from reward, through parallel and flexible popu...

It's officially published!! In my main postdoc work with @markplitt.bsky.social and @lgiocomo.bsky.social, we found that the hippocampus simultaneously encodes an animal's spatial position and its experience relative to reward in parallel population codes. 🧵

www.nature.com/articles/s41...

Systems consolidation reorganizes hippocampal engram circuitry Nature - A study shows that loss of memory precision associated with systems consolidation can be explained by neurogenesis-dependent reorganization of engram circuitry within the hippocampus over...

Sharing a new paper from the lab. This paper, led by Sangyoon Ko, represents a merging of two longstanding research themes in the lab-- adult neurogenesis and systems consolidation.

rdcu.be/el18q

A short thread follows for those interested.

1/n

Impressive study from Richard Morris's group:

Hippocampal reactivation of planned
trajectories is required for effective goal
choice in an allocentric memory task

#hippocampus #neuroskyence #navigation #memory #planning

www.biorxiv.org/content/10.1...

The estrous cycle modulates hippocampal spine dynamics, dendritic processing, and spatial coding Histological evidence suggests that the estrous cycle exerts a powerful influence on CA1 neurons in the mammalian hippocampus. Decades have passed sin…

🚨Very excited to share a new paper from our lab in Neuron (@cp-neuron.bsky.social) on the influence of the estrous cycle on structural and functional plasticity in the hippocampus: www.sciencedirect.com/science/arti...
Thread below 🧠🧪🧵:

Our paper in @natcomms.nature.com, we show how cognitive maps in the hippocampal system could solve the general problem of representing and relating multiple alternative action plans. 
doi.org/10.1038/s414...

With @doellerlab.bsky.social, Patrick Haggard, @vigano.bsky.social, Daniel Reznik

Motor learning refines thalamic influence on motor cortex - Nature Imaging and optogenetics in mice provide insight into the interplay between the primary motor cortex and the motor thalamus during learning, showing that thalamic inputs have a key role in the executi...

Our paper is out in Nature.

By examining various inputs to the motor cortex during learning, we found that thalamic inputs learn to activate the cortical neurons encoding the movement being learned.

Tour de force by Assaf in collab with Felix and Marcus. Congrats!

www.nature.com/articles/s41...

So great to hear, congratulations Mari! 🎉 Boulder is lucky to have you!

Cold memories control whole-body thermoregulatory responses - Nature Cold-sensitive engrams contribute to learned thermoregulation in mice that are returned to an environment in which they previously experienced a cold challenge, through a network formed betw...

Very excited to share part of my postdoctoral work from the @tjryan.bsky.social lab, out now in @nature.com. Here, my brilliant co-author @andreamunozz.bsky.social and I explored the link between memory engrams and whole-body metabolism.

A thread: 🧵

www.nature.com/articles/s41...

Very excited to share the first preprint of my PhD thesis!

Together with @tschreiner.bsky.social, we investigated how respiration coordinates signature neural expressions of successful remembering during memory retrieval. 🫁🧠

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Memories of a cold place trigger bodily responses to warm up Neurons involved in forming memories of a cold environment communicate with the part of the brain that regulates metabolic responses to cold stress.

Neurons involved in forming memories of a cold environment communicate with the part of the brain that regulates metabolic responses to cold stress

https://go.nature.com/4lP2EHa

Region-specific nucleus accumbens dopamine signals encode distinct aspects of avoidance learning Avoidance learning—learning to avoid bad outcomes—is an essential survival behavior. Dopamine signals are widely observed in response to aversive stim…

Pleased to share the final published version of @glopez.bsky.social's work in @currentbiology.bsky.social! www.sciencedirect.com/science/arti...

"Region-specific nucleus accumbens dopamine signals encode distinct aspects of avoidance learning"

Congrats, Gaby!!!

Does your research involve comparing experimental conditions? Then our latest publication is for you: We developed generalized contrastive PCA (gcPCA), a tool for comparing high-dimensional datasets. 🧠📊 doi.org/10.1371/journal.pcbi.1012747
This tool was born out of necessity, here is the story. 🧵
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