Dima Daccache

We are excited to share that our latest work from the lab aimed at understanding how the tRNA nuclease SLFN11 is activated in response to DNA damage and replication stress has just been published in @natcellbio.nature.com!

Open access link: www.nature.com/articles/s41...

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I’m happy to present a new paper from the lab, where we investigated how the yeast Spo11 core complex dimerizes to induce the formation of meiotic DNA double-strand breaks. 🧵

www.biorxiv.org/content/10.6...

Distinct ATRX functions cooperate with 9-1-1 and CST complexes to safeguard replication and telomere integrity Mutations in the ATRX chromatin remodeller predispose to a developmental genetic disorder and cancer, but how it safeguards genome and telomere stability remains unresolved. Here, we uncover critical ...

🧬 Preprint alert!

"Distinct ATRX functions cooperate with 9-1-1 and CST complexes to safeguard replication and telomere integrity."

Read the manuscript here 👉 www.biorxiv.org/content/10.1...

A scientist in a lab coat looks through a microscope in a laboratory, with other researchers blurred in the background. Overlaid text reads: “Record Applications – Choose Europe: EU research fellowships attract record 17,058 applications.” The European Commission logo appears in the bottom right corner.

The 2025 call for #MSCA Postdoctoral Fellowships drew 17,058 applications worldwide.

A 64.6% increase from 2024, it's the most popular call in over four decades.

Excellence thrives where it is enabled, protected and shared — and Europe provides that environment.

→ europa.eu/!jcnGgP

#ChooseEurope

AlphaGenome: AI for better understanding the genome Introducing a new, unifying DNA sequence model that advances regulatory variant-effect prediction and promises to shed new light on genome function — now available via API.

deepmind.google/discover/blo...

Couldn't be prouder of this amazing achievement. Congratulations @ccb-lab.bsky.social 💃🏻🥳

New preprint from the lab! We defined the kinetics of strand invasion during meiosis in C. elegans. Great work from Antonia, Henry and Divya.
www.biorxiv.org/content/10.1...

Osmotic disruption of chromatin induces Topoisomerase 2 activity at sites of transcriptional stress - Nature Communications Transcription creates superhelical stress in DNA, challenging genome stability. Here the authors find Top2 activity is uncorrelated with transcription unless chromatin is disrupted suggesting that chr...

Delighted to share the ground-breaking work from BBSRC Discovery Fellow @whgittens.bsky.social mapping physiological Top2 activity without poisons. Acute sensitivity enables sub-minute visualisation of Top2 hotspots hidden within sites of latent topological stress: www.nature.com/articles/s41...

Meiosis: Exploring diversity to discover the fundamentals Meiosis is an essential cell division for sexual reproduction and fertility across eukaryotes. It involves a series of tightly regulated processes, including entry into meiosis, pairing of homologs, …

Registration now open for the 2025 EMBO workshop on Meiosis! June 22-26, 2025, Engelberg, Switzerland.
Deadline for abstract submissions and registration is Feb 15th, 2025. Lots of speaker slots will be selected from abstracts, so apply now! meetings.embo.org/event/25-mei...

Experimental results showing DNA break formation by purified SPO11 protein. Above is an image of an electrophoresis gel, below is a graph showing quantification of the DNA cleaving activity

Hi Bluesky. For my first post, I'd like to advertise the latest preprint from my lab, describing at long last our reconstitution of SPO11-dependent double-strand break formation from purified recombinant proteins. Outstanding work from PhD student Zhi (Zack) Zheng.

Here is the paper by the Keeney lab:
www.biorxiv.org/content/10.1...

SPO11 dimerization controls meiotic DNA double-strand break formation SPO11 initiates meiotic recombination through the induction of programmed DNA double-strand breaks (DSBs), but this catalytic activity had never been reconstituted in vitro. Here, using Mus musculus S...

So happy to see this amazing achievement from @ccb-lab.bsky.social out!

www.biorxiv.org/content/10.1...

SPO11 dimerization controls meiotic DNA double-strand break formation SPO11 initiates meiotic recombination through the induction of programmed DNA double-strand breaks (DSBs), but this catalytic activity had never been reconstituted in vitro. Here, using Mus musculus S...

Hello Bluesky, for my first post here I'm happy to share our latest preprint reporting the first biochemical reconstitution of DNA double-strand break formation by SPO11.

SPO11 dimerization controls meiotic DNA double-strand break formation.
www.biorxiv.org/content/10.1...

Meiosis: Exploring diversity to discover the fundamentals Meiosis is an essential cell division for sexual reproduction and fertility across eukaryotes. It involves a series of tightly regulated processes, including entry into meiosis, pairing of homologs, …

Official website for EMBO meiosis 2025 is live now! Looking forward to seeing you in Switzerland next June! #meiosis4eva

meetings.embo.org/event/25-mei...