Pedro Papotto

On the use of murine models: Results should be interpreted with caution. Batf3-deficient mice have been traditionally used as a model to study the function of cDC1; however, this transcription factor seems to play other essential roles in other immune populations👇

Our unexpected results indicate that BATF3 affects the peripheral maintenance of different subsets of innate-like gd T cells after they complete their thymic development.

This is the result of a great collab with Miguel Muñoz-Ruiz, Elena Hernández and @salva-iborra.bsky.social and many other amazing people that helped us to make this happen!

BATF3 controls the homeostatic maintenance and function of innate-like γδ T cells γδ T cells compose an evolutionarily conserved lineage of lymphocytes, with both adaptive- and innate-like characteristics, contributing to tissue homeostasis, immune surveillance, and rapid responses...

Isn't this the coolest Christmas present (or miracle) for a #gdTcell aficionado?! Our latest preprint showing the role of BATF3 on gd T cells is ou on bioRxiv:
www.biorxiv.org/content/10.6...

BATF3 controls the homeostatic maintenance and function of innate-like γδ T cells https://www.biorxiv.org/content/10.64898/2025.12.16.694583v1

Excited to share our new paper in
@jem.org! 🎉
We reveal a key mechanism showing how tissue-resident memory CD8⁺ T cells (#Trm) amplify antiviral protection during reinfection. #immuno
🧵👇1/6

My PhD work is (finally) published in Science Signaling! And it made the cover!

Here’s what we found 🧵⬇️

www.science.org/doi/10.1126/...

Research Associate | King's College London

We are recruiting!!! Postdoc position available in my lab to develop this exciting project with @alexfsantos2401.bsky.social advance our understanding of food allergy and oral tolerance in early life. #ILC #organoids #FoodAllergy

www.kcl.ac.uk/jobs/128585-...

(MCR DTP) Macrophage clearance of hyaluronan: mechanisms and consequences for lung disease at The University of Manchester on FindAPhD.com PhD Project - (MCR DTP) Macrophage clearance of hyaluronan: mechanisms and consequences for lung disease at The University of Manchester, listed on FindAPhD.com

📣 PhD project available 📣
Interested in immuno-matrix interactions and matrix regulation?
This project will investigate how hyaluronan is cleared from the lungs after infection. 🫁
@profjudiallen.bsky.social
@lydiabeckeriii.bsky.social @mcrcellmatrix.bsky.social

www.findaphd.com/phds/project...

Decoding γδ T cell-epithelial interactions in the human intestine in health and disease - MRC DTP The human gut epithelium performs vital absorptive functions, while simultaneously forming a physical barrier between the gut contents and the body. As such it is essential for health and its dysregul...

PhD opportunity to study intestinal immune cells using our pioneer human organoid models at the Joana F Neves and Robin Dart labs @kingscollegelondon.bsky.social through #MRC Doutoral training program
kcl-mrcdtp.com/project/deco...
Applications opening soon!
#gdTcells #IBD #gut #organoids

Needing some help from all the mouse doctors around! Does anyone know who might keep a B10.D2 mouse colony in the UK (or even mainland Europe)?

Centre to study how exposome causes chronic inflammatory disease A new Medical Research Council (MRC) centre will investigate how the environment interacts with our immune system to trigger chronic inflammatory diseases.

Super excited to announce that MRC has funded a new Centre of Research Excellence in Exposome Immunology. Working together, Manchester and Oxford are going to tackle a major challenge of our times. For those who wonder what the Exposome is - see yesterday's posts! www.ukri.org/news/centre-...

New £50m MRC Centre to study how environmental exposures cause chronic inflammatory diseases A groundbreaking £50M research centre at Manchester and Oxford will explore how environmental exposures, like pollution and microbes, rewire our immune system and drive chronic inflammatory diseases.

🚨 A new £50M MRC Centre at @manchester.ac.uk and @ox.ac.uk will explore how pollution, microbes & other environmental exposures rewire our immune system and cause chronic inflammatory diseases.
#Exposome #ImmunoSky

sites.manchester.ac.uk/lydia-becker...

Research Associate in Synthetic Chemistry and Chemical Biology:Oxford Road

Delighted to advertise a collaborative postdoc position available in the lab to develop new proximity labelling tools, funded by a BBSRC Transformative Research Technology grant:

www.jobs.manchester.ac.uk/Job/JobDetai...
#ChemicalBiology #SyntheticChemistry

Interested in working on Mucorales adaptation? Thanks to new funding from @wellcometrust.bsky.social, we will have two postdoc and a technician positions advertised very soon! if interested, please get in touch for more information.

ICYMI: Junior PI positions in Kyoto at @ccii-kyoto.bsky.social, a new center led by Tasuku Honjo (DIrector) & Sidonia Fagarasan (Vice Director)
#Immunology #Immunotherapy #ScienceJobs

🚨Great new MSc and PhD positions available @gimmfoundation!

Check out the links or use the QR code.

MSc:
www.medicina.ulisboa...

PhD:
gimm.pt/course/phd-p...

The deadline for this PhD is fast approaching. We are looking for a promising synthetic chemist to make new chemical biology tools to learn more about nucleic acid interactions. This is a collaborative project with the Trowbridge Lab in @uomscieng.bsky.social. If interested, get in touch soon!

Inhibitory TIGIT signalling is dependent on T cell receptor activation TIGIT is an immune checkpoint receptor that can signal via cytoplasmic ITT-like and ITIM motifs to regulate T cell function. The signalling molecules that mediate inhibitory TIGIT signalling in T cell...

Our latest research is now available as a pre-print at BioRxiv. We show that the immune checkpoint receptor TIGIT cannot signal in T cells without simultaneous TCR stimulation.

#ImmunoSky

www.biorxiv.org/content/10.1...

Hi everyone 👋 I’ve been nominated for the role of ECR representative position on the Member Representative Forum at @britsocimm.bsky.social. If you’d like to see me in this position and want to vote for me, you can follow this link: www.immunology.org/news/bsi-com... #immunosky

(EPSRC DTP) Super-resolution proximity nucleotide labelling at The University of Manchester on FindAPhD.com PhD Project - (EPSRC DTP) Super-resolution proximity nucleotide labelling at The University of Manchester, listed on FindAPhD.com

We have a PhD available in the lab to design new chemical tools to do super resolution proximity labelling of nucleotides. Come join us!!

#ChemSky #ChemBio

www.findaphd.com/phds/project...

So excited to share our first neuro focused paper from the lab, we show that CXCL4 (PF4) is transported into the brain by proteoglycans within the endothelial glycocalyx and that GAG binding also mediates the pro neurogenesis effects of CXCL4. www.biorxiv.org/content/10.1...

Nerve- and airway-associated interstitial macrophages mitigate SARS-CoV-2 pathogenesis via type I interferon signaling The local immunoregulatory mechanisms that safeguard the host from excessive lung infection inflammation remain unclear. Yeung, Yokota et al. uncover the essential role of nerve- and airway-associated...

Excited to share our latest study
@cp-immunity.bsky.social. Heartfelt thanks to the editorial and review teams , to my co-first @yeungadventures.bsky.social, our co-authors, and to @khannakm.bsky.social
for his outstanding mentorship throughout! Pls read/share!👇
www.cell.com/immunity/ful...

Dual modulation of cytotoxic and checkpoint receptors tunes the efficacy of adoptive Delta One T cell therapy against colorectal cancer - Nature Cancer Silva-Santos and colleagues provide in vivo preclinical evidence supporting a therapeutic use of Delta One T cells to tackle colorectal cancer and propose activating natural killer cell receptor NKG2D...

Dual modulation of cytotoxic and checkpoint receptors tunes the efficacy of adoptive Delta One T cell therapy against colorectal cancer.

#gdTcells

Brain sensing of metabolic state regulates circulating monocytes Brain-initiated hunger signals control circulating monocyte dynamics.

Our latest study
@science.org #Immunology on perception of #hunger and #immunity.

#BrainBody #Melanocortin #AgRP #POMC neurons. #Brain-liver axis. Permissive action of #stress #hormones.

@ukri.org @fbmh-uom.bsky.social

www.science.org/doi/10.1126/...

a close up of a woman 's face with a surprised look on her face . Alt: a close up of a woman 's face with a surprised look on her face .

What really happens to your immune system when you fast?

New research from @fbmh-uom.bsky.social could be a game-changer for how we think about immunity, nutrition, and inflammation.

Let’s break it down. #scicomms

Scientists cast new light on how fasting impacts the immune system New research from The University of Manchester may reshape our understanding of what happens to the immune system when we fast.Funded by the Biotechnology and Biological Sciences Research Council (BBS...

www.manchester.ac.uk/about/news/s...

Really thrilled to have been awarded an @acmedsci.bsky.social Springboard Award! This new PI thing is definitely starting to feel real now!

The #Springboard25 will help me to kickstart some cool work on innate-like T cells in skin and lungs at the @lydiabeckeriii.bsky.social! Exciting times ahead!

Three people wearing lab coats and talking to each other while writing on a whiteboard

📢 We're making our largest ever investment in early-career researchers

Through #Springboard25, we’re investing £7.6m in 62 researchers to drive innovations that improve health and wellbeing 🔬

Congrats to all 2025 awardees! 🎉

👉 bit.ly/springboard2...

@thebhf.bsky.social @wellcometrust.bsky.social

Research Associate in Imaging Human Immunology:Oxford Road

Our lab has a postdoc position available to use super-resolution microscopy to understand how nanoscopic localisation of immune checkpoints dictates their function.

Please get in touch if interested in applying.

www.jobs.manchester.ac.uk/Job/JobDetai...

#ImmunoSky #Imaging #Microscopy