Florian Buchkremer

Nephrologists deported
Grants defunded
NIDDK folded into National Institute of body parts
AHRQ demolished
Now this…

When are our organizations going to speak up?

#NephSky

Use of Artificial Intelligence in Scientific Writing. The Danger of Trying Too Hard to Please The author describes his experience using several artificial intelligence programs to assist in the process of editing or preparing manuscripts for publication. While the programs were very useful to...

Hilarious (and sobering) essay on the use of AI in medical research & manuscript writing

Read the whole thing!

John Daugirdas has been on the cutting edge of tech in meded before #MedEd was thing

onlinelibrary.wiley.com/doi/10.1111/...

#MedSky #NephSky

I am BEGGING major journals to stop platforming the current administration's politicization of the FDA, CDC, vaccines, etc

This sort of evidence-lite, glitzy puff piece seems appropriate for a newspaper OpEd, not a medical journal.

Platforming it in a major journal gives it the veneer of validity.

The Aldosterone Blockade for Health Improvement Evaluation in End-Stage Renal Disease (ACHIEVE) Trial: Rationale and Clinical Research Protocol - Michael Walsh, David Collister, Martin Gallagher, Patr... Background: The mineralocorticoid aldosterone may contribute to the risk of cardiovascular morbidity and mortality in patients receiving maintenance dialysis. W...

It's been a long journey but today we can share the methods and rationale for the #ACHIEVEtrial (Spiro vs placebo for patients with kidney failure receiving maintenance dialysis) and tomorrow we share the results at #era25
journals.sagepub.com/doi/10.1177/...

Update to our supersaturation and kidney stone risk assessment tool:

We have added calcium to citrate ratios to the result section providing even greater risk assessment tools to the kit. Thanks very much to Vladimir Belostotsky for the idea!

ukidney.com/calculators/...

Blood Pressure–Lowering Medications, Sodium Reduction, and Blood Pressure | Hypertension BACKGROUND: Both blood pressure–lowering medication and sodium reduction are effective in hypertension control, but whether the effect of sodium reduction differ across blood pressure–lowering medicat...

This systematic review shows blood pressure reduction from sodium reduction in the context of antihypertensive medication use.

Blood Pressure–Lowering Medications, Sodium Reduction, and Blood Pressure | Hypertension www.ahajournals.org/doi/10.1161/...

The “spurious“ measurement in pseudohyponatremia is actually the direct ISE. Nevertheless, it is most helpful, because it correlates with the plasma sodium activity as we are used to from non-lipemic/non-hyperproteinemic samples.

Yet, the labeling of row 4 is a little unfortunate: By calling it the “reported“ sodium concentration (instead of plasma concentration) they wrongfully imply, that the value is incorrect or “spuriously low“ -as they say in the text …

… and the approximate 5th percentile CKD-EPI 2009 reference values are easy to memorize👇👇👇👇

Age- and sex-specific reference values of estimated glomerular filtration rate for European adults Kidney function, often assessed by estimated glomerular filtration rate (eGFR), declines naturally with age. However, there is a lack of eGFR reference values to describe normal and abnormal values fo...

This is such a great resource:
www.kidney-international.org/article/S008...
#nephrology #eGFR

🧵5 Top Free Alternatives to BioRender for Scientific Illustrations!

These five websites offer free scientific illustrations for biologists. Great for presentations, research papers and other research communication needs.

Save and share the post!

Germany's Plan for an Open and Independent PubMed Safety Net - Absolutely Maybe A few months ago, I wrote about reasons to be concerned about the reliability of PubMed under the new regime at the…

This is so exciting! The German National Library of Medicine @zbmed.bsky.social just had its first open meeting on the plan for an open & independent PubMed safety net. Here's my write-up @plos.org on the meeting & how institutions & others can help absolutelymaybe.plos.org/2025/05/14/g...
#MedLibs

Figure 2. Change in Home SBP in Patients Treated With Amiloride vs Spironolactone

Amiloride was noninferior to spironolactone in lowering home systolic blood pressure at 12 weeks.

https://ja.ma/42XMGD9

RBC cast - brightfield with SM stain - from new case of MPA - #UrineMicroscopy #UrinarySediment

Thrilled to unveil the first-in-human use of #apelin in #hyponatremia at #ECE2025 in Copenhagen.
Endless gratitude to @christ-crain.bsky.social for championing bold research paths, and to @julierefardt.bsky.social and @fichapman.bsky.social, whose groundwork paved the way for this endeavor

This is absolutely amazing!
👏👏👏👏👏👏👏👏👏👏👏

🧵 Introducing the EQUIL2 Urinary Supersaturation Calculator

A powerful web-based tool for nephrologists and researchers to assess kidney stone risk with ease. Based on the validated EQUIL2 algorithm from peer-reviewed scientific literature.

ukidney.com/calculators/...

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A quick #VEXUS thread 🧵-

3 reasons why the portal vein is the most useful single venous doppler waveform 🥇

(if you're only going to do ONE site to look for venous congestion, this is probably the most useful one!)

#emimcc

Efficacy and Safety of Obinutuzumab in Active Lupus Nephritis | NEJM Obinutuzumab, a humanized type II anti-CD20 monoclonal antibody, provided significantly better renal responses than placebo in a phase 2 trial involving patients with lupus nephritis receiving stan...

8/Simultaneous publication #ISNWCN

www.nejm.org/doi/full/10....

Xenotransplantation of a Porcine Kidney for End-Stage Kidney Disease | NEJM Xenotransplantation offers a potential solution to the organ shortage crisis. A 62-year-old hemodialysis-dependent man with long-standing diabetes, advanced vasculopathy, and marked dialysis-access...

Another @nejm.org simultaneous publication during #ISNWCN, about xenotransplantation

Xenotransplantation of a Porcine Kidney for End-Stage Kidney Disease

www.nejm.org/doi/full/10....

Revolutionary Pig-to-Human Kidney Transplant Trial Gets Historic FDA Green Light United Therapeutics advances xenotransplantation with FDA clearance for UKidney™ human trials, offering hope to 557,000+ dialysis patients. First transplants planned for 2025.

#UTHR United Therapeutics Corporation Announces FDA Clearance of its Investigational New Drug Application for the UKidney Xenotransplantation Clinical Trial

https://www.stocktitan.net/news/UTHR/united-therapeutics-corporation-announces-fda-clearance-of-its-i9jdr5owbet7.html

A bird's-eye view of a former Auschwitz II-Birkenau camp showing a wide dirt pathway flanked by parallel rows of barbed-wire fences. Groups of visitors walk along the path, surrounded by the remnants of brick structures and barracks, now reduced to foundations. Green grass contrasts with the somber history of the site, as the path leads toward a guard tower in the distance.

Auschwitz was at the end of a long process. It did not start from gas chambers.

This hatred was gradually developed by humans. From ideas, words, stereotypes & prejudice through legal exclusion, dehumanization & escalating violence... to systematic and industrial murder.

Auschwitz took time.

A Patient With Unmeasurable Urine Creatinine A 74-year-old female presented with proteinuria at the nephrology department. Her medical history noted multiple cerebrovascular accidents. Her medication included a daily dosage of clopidogrel 75 mg,...

This is interesting

Aerococcus sanquinicola and Aerococcus urinae in the urine metabolizing creatinine resulting in false low readings with implications for UPCR, UACR and 24 hour urine creatinine collections

www.kireports.org/article/S246...

This is me : this is how I scan electronic health records when I try to find the cause of a kidney issue or sort out a complicated medical history.
I have refrained from using the phrase "binary search" with my trainees as many will tune out because "computers," but perhaps I should start?

Doing a fistulagram and the wire goes through a 99% blocked stenosis on the first try! @asdinnews.bsky.social

SGLT2 Inhibitor #SGLT2i in #Diabetic and #NonDiabetic Renal #Transplant Recipients

#VisualAbstract by @DrPSVali

www.kireports.org/ar...

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[Why] is furosemide susceptible to malabsorption from "gut edema"?

When a patient with heart failure is hospitalized with congestion I often hear "let's use IV furosemide; they're probably not absorbing the PO."

It's a comment unique to furosemide.

But is it accurate?

Went up slightly from 30 to 35 mmol/d.