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Gleason Research Group

@gleason-group.bsky.social

Organic and Medicinal Chemistry at McGill University Group website: http://gleason-group.mcgill.ca

278 Followers  |  43 Following  |  5 Posts  |  Joined: 07.10.2024  |  1.6927

Latest posts by gleason-group.bsky.social on Bluesky

And thanks to Sophie Rousseaux (U of T) for being the external examiner on Anthony's thesis.

03.03.2025 16:46 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Congrats to Anthony Izzotti on a successful thesis defence. Amazing work on cyclopropane expansions, conformational effects of spirocyclopropane-cyclohexanes and once and for all proving that the [14+2] cycloaddition of heptafulvalene is not a Woodward-Hoffman controlled process.

03.03.2025 16:46 โ€” ๐Ÿ‘ 2    ๐Ÿ” 0    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0

This looks like a disaster for US University funding.

08.02.2025 00:07 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Cyclopropyl effect causes substituents on cyclohexane to favour axial conformation 'Unusual stereocontrol element' will help medicinal chemists increase three-dimensionality of drug candidates

A nice write-up of our recent work on the axial-promoting effect of cyclopropanes.

www.chemistryworld.com/news/cyclopr...

07.11.2024 22:58 โ€” ๐Ÿ‘ 5    ๐Ÿ” 2    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
Driving tert-Butyl Axial: The Surprising Cyclopropyl Effect The presence of a small spirocyclic ring at an adjacent position alters the conformational preference for equatorial substitution in six-membered rings. DFT calculations and low-temperature 1H NMR exp...

For our first Blue Sky post: Our paper on the surprising effect of cyclopropanes on A-values is now out (in preliminary form) in Chem. Sci. If you want to push a large or electronegative group axial on a ring, just stick a cyclopropane next to it.

pubs.rsc.org/en/content/a...

09.10.2024 01:01 โ€” ๐Ÿ‘ 4    ๐Ÿ” 1    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

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