Matt Hoare

Christmas holidays in Cambridge

Reversing the rise of liver cancer Imagine a future where the global incident cases of liver cancer almost doubles, rising from 870 000 cases in 2022 to over 1·5 million in 2050. This scenario, and all the attendant harms to health and...

🩺 Liver cancer cases could double by 2050

A new @thelancet.com Commission warns of 1.5M annual liver cancer cases by 2050 but says 60% are preventable through better HBV vaccination & alcohol reduction.

Prevention is possible. Action is urgent.

🔗 www.thelancet.com/journals/lan...

#SciComm 🧪

Lifestyle changes and vaccination ‘could prevent most liver cancer cases’ Lancet Commission says three in five cases preventable with action on obesity, alcohol and hepatitis

www.theguardian.com/society/2025...

Policy changes and enhanced early detection key to reducing death from HCC.

Registrations for the Early Cancer Institute Annual Symposium 2025, focusing on the latest developments in early cancer research, are open!

📅 Thurs 9 October 2-6pm
📍 CRUK Cambridge Institute, CB2 0RE
Find out more and register ➡️ zurl.co/bH4wU

@cambridgebrc.bsky.social @cambridge-scm.bsky.social

Great job @lily-wu.bsky social!!

Great to be at the Bridgewater Hall in Manchester for the annual HCC-UK conference. Exciting day of great speakers.

Selection for somatic escape variants in SERPINA1 in the liver of patients with alpha-1 antitrypsin deficiency - Nature Genetics The expansion of clones with distinct SERPINA1 somatic mutants in the livers of alpha-1 antitrypsin deficiency (A1AT) patients is consistent with convergent evolution. These variants interfere with th...

Excited to share our new preprint demonstrating somatic rescue mutations in a genetic liver disease! [1/12]

www.nature.com/articles/s41...

Great collaboration with Peter Campbell and colleagues at the @sangerinstitute.bsky.social, @profmarciniak.bsky.social and @joechambers.bsky.social

Selection for somatic escape variants in SERPINA1 in the liver of patients with alpha-1 antitrypsin deficiency Nature Genetics - The expansion of clones with distinct SERPINA1 somatic mutants in the livers of alpha-1 antitrypsin deficiency (A1AT) patients is consistent with convergent evolution. These...

Delighted to announce our new paper by Natalia Brzozowska published today, demonstrating somatic escape mutants from a deleterious germline disease.

rdcu.be/ecSNo

Selection for somatic escape variants in SERPINA1 in the liver of patients with alpha-1 antitrypsin deficiency - Nature Genetics The expansion of clones with distinct SERPINA1 somatic mutants in the livers of alpha-1 antitrypsin deficiency (A1AT) patients is consistent with convergent evolution. These variants interfere with th...

Delighted to have this work published today.

A superb collaboration with @matthoare20.bsky.social and @joechambers.bsky.social

www.nature.com/articles/s41...

1/n

👩‍💻Research Assistant in Computational Biology
🧬analyse somatic mutations in #HCC
👨‍⚕️international collaboration with Dr Matt Hoare @matthoare20.bsky.social
🌍based at the Early Cancer Institute, University of Cambridge (UK)
🗓️apply by 31 March 2025 www.jobs.cam.ac.uk/job/50461/

🚨🚨Job Alert🚨🚨
Do you have skills in computational biology? Do you want to work on somatic mutations in #hcc?? Do you want to work in an international collaboration with @s-j-aitken.bsky.social? Come and join us in Cambridge!
🗓️ Closing date 31/Mar/2025
www.jobs.cam.ac.uk/job/50461/

Human-correlated genetic models identify precision therapy for liver cancer Nature - As proof of principle, an analysis using a suite of human-aligned immunocompetent mouse models of hepatocellular carcinoma identifies a promising therapeutic candidate, cladribine, which...

Many congratulations to Tom Bird and team from @cruk-si.bsky.social for the new paper on correlation between and human #HCC and murine models with specified oncogenic drivers. A landmark paper years in the making:
rdcu.be/eaxE2

Post-doctoral Research Associate (Fixed Term) - Job Opportunities - University of Cambridge Post-doctoral Research Associate (Fixed Term) in the Department of Medicine at the University of Cambridge.

📢 Job opportunities!

We're hiring a postdoctoral Research Associate (Fixed Term) in structural biology to join Professor Arthur Kaser's lab at #CITIID and study purine metabolism, autoimmunity, and inflammation.

Apply by 2 February: https://buff.ly/4jmVgkR

@uniofcam.bsky.social

Medicine at the Crick The good, the bad, and the ugly: tissue somatic evolution in ageing and disease

Join our next #MedicineAtTheCrick event on Thursday 13 March, where researchers and clinicians will explore tissue somatic evolution in ageing and disease.

The event will be hosted by @ciccarellilab.bsky.social and Ilaria Malanchi
www.eventbrite.co.uk/e/medicine-a...

Burden of Metabolic Dysfunction–Associated Steatotic Liver Disease, 2020 to 2050 This decision analytical modeling study estimates the burden of metabolic dysfunction–associated steatotic liver disease among US adults from 2020 to 2050.

Estimated burden of #MASLD and #MASH over the next 30 years.😮

Future is grim if we don't take active approach from all disciplines and angles, including policy change.

jamanetwork.com/journals/jam...

someone is holding a fortune cookie that says " i love it when a plan comes together " ALT: someone is holding a fortune cookie that says " i love it when a plan comes together "

Totally rocks, when you get a student onto a PhD fellowship!

A very rare position for an immunology professorship at Cambridge. Something to think about!

www.jobs.cam.ac.uk/job/49381/

All medics and scientists interested in #HCC, the HCC-UK annual conference will be in Manchester on 27th-28th March 2025. Register now at:
hcc-uk.org.uk

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