Patrick Giraudeau

Thank you Fabien for the kind words and for this beautiful photo. 🙏

Meet the MIMM team from CEISAM at #Euromar2025 in #Oulu!

Listen to our talks and visit our posters to learn more about our developments in #NMR spectroscopy of complex mixtures, and their applications to #metabolomics and reaction monitoring!

Thanks a lot for attending!

Dear #EUROMAR Community, | Patrick Giraudeau Dear #EUROMAR Community, As organizers of #EUROMAR, we are keenly aware of the environmental impact associated with hosting an annual international conference. As part of our commitment to sustainabi...

Help us shape the future of #Euromar!!!

www.linkedin.com/posts/patric...

The MIMM team from CEISAM participates to the #GERM 2025 meeting in #Autrans! With posters from Lamia Grib and Jean-Nicolas Dumez, as well as a presentation of the #GET-RMN network by Aurélie Bernard. The #GERM bureau organises this national meeting on all aspects of magnetic resonance !

Two positions are still open in our team at CEISAM! Apply below for exciting science!

Ph.D. student in #metabolomics (3 years)
amethis.doctorat.org/amethis-clie...

Post-doc in hyperpolarized #NMR (2 years)
euraxess.ec.europa.eu/jobs/323212

📢 👨‍🔬 👩‍🔬 #PhD thesis - #NMR metabolomics for personalized medicine
Join us for an exciting project, combining innovative #NMR #metabolomics methods, #MS and statistical analysis to identify new biomarkers of cardiovascular disease.
📅 Apply before April 21st, 2025
amethis.doctorat.org/amethis-clie...

Post-doctoral researcher in dissolution Dynamic Nuclear Polarization A post-doc position in hyperpolarized NMR is available in the MIMM team of the CEISAM laboratory in Nantes, France.

Please share widely! I'm hiring! Who wants to be the first postdoc to explore the potential of a new cryogen-free dissolution DNP instrument for metabolomics? Apply before April 30! euraxess.ec.europa.eu/jobs/323212

I'm looking for our next post-doc collaborator in dissolution DNP for hyperpolarized #NMR #metabolomics ! If you like to find practical solutions to interdisciplinary problems in instrumentation, NMR and analytical chemistry, this might be your next job! Send me a message if you are interested!

Only 25 seats left! We had people registering from all over the world! This is going to be a very exciting event!

Registration is open for our #NMR #metabolomics symposium in Nantes next June!

Look at the impressive list of invited speakers! There will be plenty of oral communications selected from abstracts. Do not wait to register, attendance is limited to 100!

nmrmetabo.sciencesconf.org

😆

Patrick Giraudeau on LinkedIn: #nmr Bye bye old magnets! Follow Aurélie Bernard to monitor the progress of works and installations in the CEISAM #NMR facility throughout the year, funded by the…

Bye bye old #NMR magnets!!
Nice (controlled) quenches...the second one is quite impressive !

www.linkedin.com/posts/patric...

GlycoNMR: Magnetic Resonance in Chemistry Click on the title to browse this issue

Magnetic Resonance In Chemistry (MRC) GlycoNMR Special Collection edited by Anthony S. Serianni and Darón I. Freedberg

analyticalsciencejournals.onlinelibrary.wiley.com/doi/toc/10.1...

@patgiraudeau.bsky.social

Hyperpolarized 13C NMR Metabolomics of Urine Samples at Natural Abundance Applied to Chronic Kidney Disease NMR is a central tool in the field of metabolomics, thanks to its ability to provide valuable structural and quantitative information with high precision. Most NMR-based metabolomics studies rely on 1D 1H detection, which is heavily limited by strong peak overlap. 13C NMR benefits from a wider spectral dispersion and narrower signal line width but is barely used in metabolomics due to its low sensitivity. Dissolution dynamic nuclear polarization (d-DNP) offers an opportunity to improve 13C NMR sensitivity by several orders of magnitude. Here, we show that this emerging hyperpolarized metabolomics approach can provide meaningful information about clinical samples. Achieving sub-mM limits of detection with 13C at natural abundance in urine samples was made possible by a meticulous design of the experimental workflow. The analysis of human urine samples from patients with different stages of chronic kidney disease (CKD) was performed using 13C d-DNP NMR and benchmarked to conventional 1H NMR metabolomics at a high magnetic field to explore the complementarity between the two methods. Multivariate analysis of the d-DNP 13C NMR dataset provided a statistical model able to distinguish patients with CKD from control patients. Moreover, 13C d-DNP NMR spectra highlighted several biomarkers known to be biologically relevant. Some of them were in agreement with those obtained with conventional 1H NMR, and the results also highlighted the complementarity of biomarker coverage between hyperpolarized and conventional NMR metabolomics. In particular, 13C hyperpolarized NMR allowed the annotation of two biomarkers that could not be detected by 1H NMR because of peak overlap (i.e., guanine and guanidoacetate).

Why compromising between resolution and sensitivity in #NMR #metabolomics when you can have both? Learn more in our just published @acsjacs.bsky.social paper!

doi.org/10.1021/jacs...

@rrgil.bsky.social here are some useful starter packs for mag res on bluesky!

Welcome Roberto Gil😁 @rrgil.bsky.social
I recommend everyone to follow him for updates on Magnetic Resonance in Chemistry!

Patrick Giraudeau on LinkedIn: #erc #metabolomics Today was a very special day for the #ERC SUMMIT project in the MIMM team at CEISAM. Victor Ribay brilliantly defended his Ph.D. thesis entitled…

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Jean-Nicolas Dumez presents the flow #NMR research from the MIMM team of the CEISAM lab at the @bruker users day in Paris!

😁

Hi Rachel, could you add me as well? Thanks!

Risky, unless sample stability at ambient T° has been checked. Anyhow, it is very important that all samples undergo the exact same workflow, ie. that every single sample spends the same time out of the fridge before analysis. Avoid letting samples at ambient T° for a different time before analysis.

Good idea! Could you please add me?

Thanks for the tips!😁

Cool!

Thanks! Looks like this is where all the fun is now😁

👋