SCALE - SubCellular Architecture of LifE

Conformational Plasticity of LptC Regulates Lipopolysaccharide Transport by the LptB2FGC Complex The outer membrane of Gram-negative bacteria is coated with lipopolysaccharide (LPS). The Lpt system generates membrane asymmetry by transporting LPS from the inner to the outer membrane. Transport be...

Proud that our work is online now in @jacs.acspublications.org 🎉 A big thanks to everyone involved in this project! If you are interested have a read:

doi.org/10.1021/jacs...

GBM Compact Focus on Condensate Biology is opened by Edward Lemke. Looking forward to a great meeting!

This morning we travelled into the fascinating world of neurons and synapses with @erin-schuman.bsky.social. We learnt how protein synthesis takes place in neuronal dendrites. 🧠

@mpibrain.bsky.social

#imprs_cbp #gradschool #brain

We followed with a day packed with CryoEM! We heard about the cryoEM from Werner Kühlbrandt, STEM-EELs from Bonnie Murphy and CryoET from Martin Beck.

We're very excited to welcome the new generation of #IMPRS students during our Symposium on Cellular Biophysics 🧪 This morning, we heard spokespersons Volker Dötsch and Martin Beck, and coordinator Pamela Ornelas, introduce the doctoral program to the new students!
#imprs_cbp #biophysics #gradschool

We had a great start of the #IMPRS Symposium on Cellular Biophysics to welcome our new students. Thank you for your fascinating talks Michaela Müller-McNicoll, Bernhard Hampölz and Christian Münch 👏

#imprs_cbp #phd #biophysics

I am sooo excited. Starting tomorrow the next edition of the fabulous #emboiclip2 course begins. @koenig-lab.bsky.social, @zarnack-group.bsky.social, moi & Elias Bechara will present 3 improvements to the method, a semi-automated workflow for data analysis and an exciting line up of speakers. Ready?

Congratulations! 🎉

Celebrate with us on Sept 15, 1 PM & hear his talk: "Illuminating Biosynthetic Dark Matter: Unlocking Hidden Pathways to Discover Natural Products with Therapeutic Promise"
👉 goethe-university-frankfurt.de/150458316/Ea...
🔍 Helfrich’s research: helfrichlab.com

🎉 We congratulate Prof. Dr. Eric Helfrich on nomination for the Paul Ehrlich & Ludwig Darmstaedter Early Career Award 2026! 🔬👏

We’re looking forward to the IMPRS-CBP Symposium on Cellular Biophysics at the @mpibp.bsky.social ! Join us on Sept 15–22 for a week+ of talks from our faculty as we welcome our new students! 🧑‍🎓Learn more here: imprs-cbp.mpg.de/symposium-on...

Fresh in Nature Communications: a big update from the international biocondensate community featuring SFB1551 spokespersons @dormannlab.bsky.social and @lemkelab.bsky.social
Read more 👉 www.nature.com/articles/s41...
Congrats to all authors!

We’re hosting the @embo.org Practical Course on In-situ structural biology by CryoFIB and CryoET in April 2026! 🧬❄️ You can expect hands-on training, cutting-edge methods, and a chance to work alongside leading experts in structural biology. 🔗 Apply by Dec 8, 2025: meetings.embo.org/event/26-in-...

Congratulations Jenny, Martin and Bernhard 🥳!

🚀 Spotlight on early #career #science! On Sept 15, six outstanding young #researchers present their work at the Paul Ehrlich & Ludwig Darmstaedter Early Career Award 2026 – #Symposium in Frankfurt. Don’t miss it! | 🔗Register now lmy.de/MzPjd #GoetheUni

🧪 Who is Erin M. Schuman, winner of the 2026 HFSP Nakasone Award?

She uncovered that synapses — the brain’s communication hubs — can make their own proteins, rewriting how we think memories form.

Discover her research 👉zurl.co/niEzX

#HFSPNakasoneAward #sts

Multi-scale Simulations of MUT-16 Scaffold Protein Phase Separation and Client Recognition Phase separation of proteins plays a critical role in cellular organisation. How phase separated protein condensates underpin biological function and how condensates achieve specificity remain elusive...

🎉 Congrats to @kgaurav.bsky.social, Lukas Stelzl & @reneketting.bsky.social (SFB1551) on their new Biophysical Journal paper! #MUT16 #PhaseSeparation #MutatorFoci #SmallRNA #GeneRegulation #Celegans #ProteinAssembly #RNAResearch #MultiscaleSimulations Great teamwork👏👏👏 www.cell.com/biophysj/ful....

*Seminar Alert*

Prof. Sergej Djuranovic, PhD
Brown University, USA

Date: 02.09.2025. 15:00

Venue: Faculty of Medicine, Goethe University, Seminar room 4, Haus 23 (S23-4)

@djuranoviclab.bsky.social
@cpi-exstra.bsky.social
@scale-cluster-ffm.bsky.social
@goetheuni.bsky.social

Many congratulations!

Ribosomes On the Road: Neurons Assemble Protein Factories Far from the Nucleus New study shows ribosome biogenesis can occur within neuronal branches, challenging traditional textbook biology.

🚛 Ribosomes on the road! New research from the Schuman Lab @mpibrain.bsky.social shows neurons can locally assemble ribosomes - far from the nucleus and close to synapses. A big shift from textbook biology! 📚🧬🔗 bit.ly/3GUJKPv #Neuroscience #CellBiology #Ribosomes

🔬 This research uncovers how the splicing factor SRSF5 helps coordinate the interaction between two neighboring nuclear structures—nuclear speckles (NS) and paraspeckles (PS)—particularly during cellular stress.

Rapid depletion and super-resolution microscopy reveal dual roles of SRSF5 in coordinating nuclear speckle–paraspeckle crosstalk during cellular stress Abstract. Nuclear speckles (NS) and paraspeckles (PS) are adjacent yet distinct nuclear condensates that undergo stress-induced reorganization. Here, we id

👏Congratulations to @mixmue.bsky.social, @heilemannlab.bsky.social, and all co-authors on their recent publication in Nucleic Acids Research!
Proud to see this work arise from the collaborative efforts of SCALE faculty, including Stefan Müller and Dorothee Dormann.
academic.oup.com/nar/article/...

Prof. Franziska Matthäus in der🆕Ausgabe des unireport @goetheuni.bsky.social ehem. 🗣️von➡️LOEWE-CMMS @fias.bsky.social zu »Critical Computational Literacy @ GU Future Skills and Beyond« einem🆕 Lehrangebot zu KI & Co➡️ www.unireport.info/176087817/un... mehr zu Matthäus➡️ proloewe.de/de/persoenli...

Left: LaBeRling contact sites between the plasma membrane (green) and the endoplasmic reticulum (magenta). Contacts are highlighted in blue using LBR. Image created by Laura Downie. Right: 3D render of a membrane contact site (orange) between a mitochondrion (pink) and the ER (green contours). Image created by Stephen Royle.

#ER - #membrane contact sites are often distorted by existing labeling methods. @steveroyle.bsky.social &co present an inducible labeling system (LaBeRling) using #LaminB receptor to fluorescently tag ER-membrane contact sites in live cells, preserving morphology @plosbiology.org 🧪 plos.io/4lv6gxu

👆🏼 @tuda.bsky.social

Proud to share our first lab pre-print: “SND3 is the membrane insertase within a fungal multipass translocon” where @tzujingyang.bsky.social solved the structure of a ribosome-associated SND3-translocon complex involved in ER membrane protein insertion ➡️ doi.org/10.1101/2025...

Many congratulations to @MpiBrain Director Erin Schuman @erin-schuman.bsky.social on receiving the 2026 Nakasone Award! 🧠 @hfspo.bsky.social 👏

HIV-1 nuclear import is selective and depends on both capsid elasticity and nuclear pore adaptability pubmed.ncbi.nlm.nih.gov/40624219/ #cryoEM

Professor Thomas Prisner Awarded the 2025 Richard R. Ernst Prize in Magnetic Resonance at EUROMAR 2025 Oulu, Finland – July 7, 2025 – The 2025 Richard R. Ernst Prize in Magnetic Resonance has been awarded to Professor Thomas Prisner of Goethe University Frankfurt, in recognition of his outstanding cont...

Prof Thomas Prisner awarded the 2025 Richard R. Ernst prize in magnetic resonance at EUROMAR 2025 in recognition of pioneering contributions to biomolecular research through advances in EPR and DNP methodologies @brukercorporation.bsky.social #NMRnews #NMRchat #NMR #Euromar2025 🧲

CryoRhodopsins: A comprehensive characterization of a group of microbial rhodopsins from cold environments Spectroscopy, structural, and functional study of microbial rhodopsins with characteristic long-living near–UV-absorbing state.

This illumination protocol enabled structural snapshots of both the dark and intermediate states, linking the prolonged photocycle to a flip of the unique residue R57 that defines CryoRhodopsins.
📖 Science Advances: www.science.org/doi/10.1126/...