SCALE - SubCellular Architecture of LifE

🔬we have been playing with 'an old tool from (DNA) chemistry' 🧪 and used that for DNA-based confocal/super-res microscopy ... these are the last recordings for the revision and were recorded last night ... 🙏 thanks to R1 for this suggestion:

Goethe University now has a state-of-the-art scanning electron microscope with nanomanipulator 🤩. It enables precise nanobiopsies of biological samples and is a key technology for the Cluster of Excellence @scale-cluster-ffm.bsky.social.

🔗 Read more: aktuelles.uni-frankfurt.de/english/a-vi...

🌟 PhD positions at IMPRS-CBP! Applications open from Jan 23 – Mar 11. Fully funded PhDs in cellular biophysics at @mpibp.bsky.social , @goetheuni.bsky.social l and @unimainz.bsky.social .
👉 imprs-cbp.mpg.de
#phd #biophysics #imprs_cbp

Foto einer Palmölplantage. Darauf der Text "Designer-Enzyme statt Palmöl. Forschende der Goethe-Universität Frankfurt haben einen innovativen Ansatz entwickelt, um Fettsäuren nachhaltig zu produzieren."

🧪 Forschende der Goethe-Uni haben das Enzym Fettsäuresynthase neu programmiert, um nachhaltige Fettsäuren ohne #Palmöl zu produzieren. Durch gezielte Veränderungen können nun kürzere Kettenlängen hergestellt werden. 🔗 Mehr: aktuelles.uni-frankfurt.de/forschung/de...

@scale-cluster-ffm.bsky.social

🧪 Researchers at Goethe University have reprogrammed the enzyme fatty acid synthase to produce sustainable fatty acids without #palm#oil. Through targeted modifications, shorter chain lengths can now be produced. 🔗 More: aktuelles.uni-frankfurt.de/english/from...

@scale-cluster-ffm.bsky.social

Giersch International Conference & SCALE Kick-Off The Cluster of Excellence SCALE – SubCellular Architecture of LifE aims to build digital models of human cellular segments in molecular detail, allowing them to evolve in virtual reality through advan...

For more Information: indico.global/event/16174/

🚀 Giersch International Conference & SCALE Kick-Off on Digital Twins is coming up!

🗓️ March 2–5, 2026 | 📍 Frankfurt Main
Experts in digital twins & structural cell biology come together to discuss, challenges & future directions in biology.

Application deadline: 18 January 2026
For details and application instructions, visit:
berufungsportal.uni-frankfurt.de

Further information about SCALE can be found at:
scale-frankfurt.org

@mpibp.bsky.social @mpibrain.bsky.social @proloewe.bsky.social @unimainz.bsky.social @FIAS

⏰Call for Applications - Join Our Team and Help Shape Our Cluster

@goetheuni.bsky.social and the Cluster of Excellence SCALE - Subcellular Architecture of Life are seeking 3 highly motivated scientists to join a vibrant and innovative research community on Campus Riedberg.
Share with your network!

Many congratulations!

Vault particles, a 40-year cell biology mystery, associate with membranes at the nuclear envelope and ER—revealing a new functional axis for these conserved complexes @kgeissler.bsky.social @yuningwang.bsky.social @jpkreysing.bsky.social @Becklab.bsky.social: www.biorxiv.org/content/10.6...

The last chapter from my postdoc days is finally online! We solve structures of the ER membrane O-mannosyltransferase Pmt4 and uncover a functionally important cytosolic binding site for the Dol-P-Man substrate lipid - allosteric regulation or a long sought after Dol-P-Man flippase?? 🔄 rdcu.be/eUJfb

Holy cow the Zhou lab at UCLA is cooking with Isonet 2 - www.biorxiv.org/content/10.6...

Averaging-free direct visualization of ribosome translational state! #teamtomo #cryoet

How liquid-like is the nuclear pore barrier?🍝𖣐
Our new preprint shows that FG-NUPs exhibit nanosecond-scale, liquid-like mobility in living cells. 💧⚡O-GlcNAcylation and an importin-β gradient keep the FG network liquid-like, reconciling nuclear pore complex models.

Before you decorate the tree, come decorate your RNA next Thursday, 4 pm, 18.12.2025

Our last RNA event before the holidays.

Also:Glühwein&snacks

Registration: rmu-rna-salon.idloom.events/2-rmu-rna-sa...

Please share
@mixmue.bsky.social @cpi-exstra.bsky.social @scale-cluster-ffm.bsky.social

It’s out 🥳🥳. Amazing new insights into Paraspeckles by SMART 3D STED imaging. Paraspeckles can be polar and fuse and have an interesting loop that contacts the nucleoplasm. Kudos to @heilemannlab.bsky.social, Sjoerd Stallinga and Bernd Rieger.

One of our founding directors Anthony Hyman @hymanlab.bsky.social will become @embl.org Director General: www.mpi-cbg.de/news-outreac...

Exceptional work by Enya (TU Delft) and Laurell (Frankfurt) 💪 and a great team 👍 & great support by our Exc Cluster @scale-cluster-ffm.bsky.social @goetheuni.bsky.social & we thank our Editor and the Reviewers for their valuable input @natcomms.nature.com

#FluorescenceFriday #smartmicroscopy #RNA

We developed a 'smart STED microscope' to detect rare objects/events in cells, and unraveled the 3D morphology of a nuclear membraneless organelle (paraspeckle). Amazing collaboration with Sjoerd Stallinga, Bernd Rieger (TU Delft) and @mixmue.bsky.social 🙏 (1/3) www.nature.com/articles/s41...

🚨🔬A great opportunity to work with high-end microscopy in an exciting scientific environment. Please re-post 🙏 @goetheuni.bsky.social @scale-cluster-ffm.bsky.social
👇🏻

A great opportunity to join our newly established imaging centre in Frankfurt as engineer/technician. If you love light microscopy, please apply!
Please share!

Nuclear-import receptors remodel the dilute phase to suppress phase transitions of RNA-binding proteins with prion-like domains. RNA-binding proteins (RBPs) with prion-like domains, including FUS, hnRNPA1, and hnRNPA2, assemble into functional, metastable condensates that organize ribostasis, but can also transition into self-t...

www.biorxiv.org/content/10.1...

💥"RMU-EXCITE": Die Allianz der Rhein-Main-Universitäten (RMU) @goetheuni.bsky.social, @unimainz.bsky.social und @tuda.bsky.social hat ihren gemeinsamen Antrag als #Exzellenzverbund (Förderlinie Exzellenzuniversitäten) eingereicht! Pressemitteilung: www.rhein-main-universitaeten.de/news/rhein-m...

📢 We’re hiring an Office and Financial Coordinator to support our team’s administrative operations. Learn more and apply here 👉

©Mentoring Hessen

🚀 #Karriere im Blick? #Mentoring Hessen unterstützt #Frauen auf ihrem Weg in Wissenschaft & Wirtschaft – mit vier Mentoring-Programmen für Studentinnen bis hin zu angehenden Professorinnen. Jetzt bis 1. Dezember (15. Dez. für ProProfessur) bewerben 👉 www.mentoringhessen.de/jetzt-bewerb...

Exciting week in Frankfurt! Our CEOS energy filter and ASI Timepix3 are installed and we're looking forward to running the first tests :) #CryoEM #timepix #REELanalysis #4DSTEM @mpibp.bsky.social

Glushkova, Böhm, & Beck @maxplanck.de develop a publicly available computational method to measure the thickness of biological membranes in cryo-electron tomograms. Analysis of algae & human cells reveals systematic membrane thickness variations within & across organelles rupress.org/jcb/article/...

Just published! We share an open-source workflow to measure membrane thickness from tomograms, including a tutorial with 3D visualizations. We analyze thickness variations across organelles and reflect on where to define a membrane boundary. @becklab.bsky.social #teamtomo rupress.org/jcb/article/...

Congratulations Melanie!