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SCALE - SubCellular Architecture of LifE

@scale-cluster-ffm.bsky.social

We are a Cluster of Excellence (EXC) based in Frankfurt, Germany, that explore the SubCellular Architecture of LifE. Our goal is to understand how the organizational principles within cells give rise to functional biological outcomes.

169 Followers  |  122 Following  |  50 Posts  |  Joined: 16.11.2024  |  2.1942

Latest posts by scale-cluster-ffm.bsky.social on Bluesky

Many congratulations!

04.08.2025 07:10 โ€” ๐Ÿ‘ 1    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Ribosomes On the Road: Neurons Assemble Protein Factories Far from the Nucleus New study shows ribosome biogenesis can occur within neuronal branches, challenging traditional textbook biology.

๐Ÿš› Ribosomes on the road! New research from the Schuman Lab @mpibrain.bsky.social shows neurons can locally assemble ribosomes - far from the nucleus and close to synapses. A big shift from textbook biology! ๐Ÿ“š๐Ÿงฌ๐Ÿ”— bit.ly/3GUJKPv #Neuroscience #CellBiology #Ribosomes

01.08.2025 13:39 โ€” ๐Ÿ‘ 14    ๐Ÿ” 4    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0

๐Ÿ”ฌ This research uncovers how the splicing factor SRSF5 helps coordinate the interaction between two neighboring nuclear structuresโ€”nuclear speckles (NS) and paraspeckles (PS)โ€”particularly during cellular stress.

28.07.2025 13:21 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Rapid depletion and super-resolution microscopy reveal dual roles of SRSF5 in coordinating nuclear speckleโ€“paraspeckle crosstalk during cellular stress Abstract. Nuclear speckles (NS) and paraspeckles (PS) are adjacent yet distinct nuclear condensates that undergo stress-induced reorganization. Here, we id

๐Ÿ‘Congratulations to @mixmue.bsky.social, @heilemannlab.bsky.social, and all co-authors on their recent publication in Nucleic Acids Research!
Proud to see this work arise from the collaborative efforts of SCALE faculty, including Stefan Mรผller and Dorothee Dormann.
academic.oup.com/nar/article/...

28.07.2025 13:21 โ€” ๐Ÿ‘ 6    ๐Ÿ” 4    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0
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Prof. Franziska Matthรคus in der๐Ÿ†•Ausgabe des unireport @goetheuni.bsky.social ehem. ๐Ÿ—ฃ๏ธvonโžก๏ธLOEWE-CMMS @fias.bsky.social zu ยปCritical Computational Literacy @ GU Future Skills and Beyondยซ einem๐Ÿ†• Lehrangebot zu KI & Coโžก๏ธ www.unireport.info/176087817/un... mehr zu Matthรคusโžก๏ธ proloewe.de/de/persoenli...

18.07.2025 08:37 โ€” ๐Ÿ‘ 6    ๐Ÿ” 2    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
Left: LaBeRling contact sites between the plasma membrane (green) and the endoplasmic reticulum (magenta). Contacts are highlighted in blue using LBR. Image created by Laura Downie. Right: 3D render of a membrane contact site (orange) between a mitochondrion (pink) and the ER (green contours). Image created by Stephen Royle.

Left: LaBeRling contact sites between the plasma membrane (green) and the endoplasmic reticulum (magenta). Contacts are highlighted in blue using LBR. Image created by Laura Downie. Right: 3D render of a membrane contact site (orange) between a mitochondrion (pink) and the ER (green contours). Image created by Stephen Royle.

#ER - #membrane contact sites are often distorted by existing labeling methods. @steveroyle.bsky.social &co present an inducible labeling system (LaBeRling) using #LaminB receptor to fluorescently tag ER-membrane contact sites in live cells, preserving morphology @plosbiology.org ๐Ÿงช plos.io/4lv6gxu

11.07.2025 13:27 โ€” ๐Ÿ‘ 26    ๐Ÿ” 9    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

๐Ÿ‘†๐Ÿผ @tuda.bsky.social

17.07.2025 12:45 โ€” ๐Ÿ‘ 1    ๐Ÿ” 1    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Proud to share our first lab pre-print: โ€œSND3 is the membrane insertase within a fungal multipass transloconโ€ where @tzujingyang.bsky.social solved the structure of a ribosome-associated SND3-translocon complex involved in ER membrane protein insertion โžก๏ธ doi.org/10.1101/2025...

12.07.2025 00:49 โ€” ๐Ÿ‘ 89    ๐Ÿ” 32    ๐Ÿ’ฌ 3    ๐Ÿ“Œ 4

Many congratulations to @MpiBrain Director Erin Schuman @erin-schuman.bsky.social on receiving the 2026 Nakasone Award! ๐Ÿง  @hfspo.bsky.social ๐Ÿ‘

11.07.2025 08:16 โ€” ๐Ÿ‘ 6    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

HIV-1 nuclear import is selective and depends on both capsid elasticity and nuclear pore adaptability pubmed.ncbi.nlm.nih.gov/40624219/ #cryoEM

08.07.2025 17:02 โ€” ๐Ÿ‘ 5    ๐Ÿ” 5    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Professor Thomas Prisner Awarded the 2025 Richard R. Ernst Prize in Magnetic Resonance at EUROMAR 2025 Oulu, Finland โ€“ July 7, 2025 โ€“ The 2025 Richard R. Ernst Prize in Magnetic Resonance has been awarded to Professor Thomas Prisner of Goethe University Frankfurt, in recognition of his outstanding cont...

Prof Thomas Prisner awarded the 2025 Richard R. Ernst prize in magnetic resonance at EUROMAR 2025 in recognition of pioneering contributions to biomolecular research through advances in EPR and DNP methodologies @brukercorporation.bsky.social #NMRnews #NMRchat #NMR #Euromar2025 ๐Ÿงฒ

07.07.2025 12:43 โ€” ๐Ÿ‘ 13    ๐Ÿ” 2    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 1
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CryoRhodopsins: A comprehensive characterization of a group of microbial rhodopsins from cold environments Spectroscopy, structural, and functional study of microbial rhodopsins with characteristic long-living nearโ€“UV-absorbing state.

This illumination protocol enabled structural snapshots of both the dark and intermediate states, linking the prolonged photocycle to a flip of the unique residue R57 that defines CryoRhodopsins.
๐Ÿ“– Science Advances: www.science.org/doi/10.1126/...

07.07.2025 15:03 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

Alternating illumination with either green or blue light allows for an efficient interconversion between the dark state and this blue absorbing intermediate state, as observed for molecular photoswitches.๐Ÿงต

07.07.2025 15:03 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0

Due to its blue color under acidic conditions, CryoR1 is set to absorb red light, a feature rarely found in nature. Under neutral to alkaline conditions, CryoRhodopsins in general possess a photocycle that lasts for minutes, including the prominent formation of an UV absorbing intermediate state. ๐Ÿงต

07.07.2025 15:03 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0

๐Ÿ” Structural: K. Kovalev @embl.orgโ€ฌ Hamburg, Prof. A. Guskov @rug.nl
โš™๏ธ Functional: Prof. T. Moser @UMC Gรถttingen
๐ŸŒˆ Spectroscopy: @wachtveitl-lab.bsky.social @goetheuni.bsky.social ๐Ÿงต

07.07.2025 15:03 โ€” ๐Ÿ‘ 1    ๐Ÿ” 0    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0

๐Ÿ‘ Special congratulations to the first authors: Gerrit Lamm, Egor Marin, and Alexey Alekseev.๐Ÿงต

07.07.2025 15:03 โ€” ๐Ÿ‘ 1    ๐Ÿ” 0    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0

๐ŸงŠ๐Ÿ”ฆ CryoRhodopsins โ€” a newly discovered clade of microbial rhodopsins found only in cold environments โ€” absorb red light under acidic conditions and behave like molecular photoswitches!

Discovered by an interdisciplinary team led by SCALE PI Prof. Dr. Josef Wachtveitl.๐Ÿงต

07.07.2025 15:03 โ€” ๐Ÿ‘ 2    ๐Ÿ” 0    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0

Many congratulations!

07.07.2025 11:13 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

Congratulations!

07.07.2025 11:12 โ€” ๐Ÿ‘ 0    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Workshop Alert: On July 10, Nathalie Weickgenannt and Laura Buglioni from @angewandtechemie.bsky.social will be at Goethe University Frankfurt to host a Wiley Publishing Workshop. Donโ€™t miss this opportunity to gain valuable insights into scientific publishing!

03.07.2025 21:03 โ€” ๐Ÿ‘ 4    ๐Ÿ” 3    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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SNAP-tag2 for faster and brighter protein labeling - Nature Chemical Biology SNAP-tag is a widespread tool for labeling protein for bioimaging. Now, Kรผhn et al. report SNAP-tag2 with increased labeling kinetics and brightness, which translates into a better performance in live...

Finally out in Nature Chem Bio:
SNAP-tag2 for faster and brighter protein labeling
www.nature.com/articles/s41...
Thank you Steffi and Veselin.

03.07.2025 19:45 โ€” ๐Ÿ‘ 172    ๐Ÿ” 76    ๐Ÿ’ฌ 3    ๐Ÿ“Œ 3
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Seminar Alert:

Prof. Igor Ulitsky, PhD
Weizmann Institute of Science

Date: 21.07.2025. 3 pm

Venue: Faculty of Medicine, Goethe University, Seminar room 1, Haus 22 (S22-1)

@igorulitsky.bsky.social @cpi-exstra.bsky.social @scale-cluster-ffm.bsky.social @goetheuni.bsky.social

03.07.2025 09:51 โ€” ๐Ÿ‘ 9    ๐Ÿ” 3    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
LinkedIn This link will take you to a page thatโ€™s not on LinkedIn

๐Ÿ‘ Thanks to host Michaela Mรผller-McNicoll @mixmue.bsky.socialโ€ฌ, keynote speakers Phillip Stansfeld & @michriscopy.bsky.socialโ€ฌ, and the amazing team behind the scenes.
๐Ÿ“ธ Photo by Uwe Dettmar
๐Ÿ”— More: lnkd.in/ecx8qUNZ

02.07.2025 13:48 โ€” ๐Ÿ‘ 4    ๐Ÿ” 1    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
LinkedIn This link will take you to a page thatโ€™s not on LinkedIn

๐ŸŽ“ Dr. @jakobsilberberg.bsky.socialโ€ฌโ€“ Interdisciplinary Work
๐ŸŽ“ Dr. @zoliviapg.bsky.social โ€“ Method Development
๐ŸŽ“ Dr. @huaipengxing.bsky.socialโ€ฌ โ€“ Scientific Contribution๐Ÿงต

02.07.2025 13:48 โ€” ๐Ÿ‘ 4    ๐Ÿ” 1    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 0
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๐Ÿ† The SCALE-it Best PhD Award 2025 celebrated groundbreaking doctoral research shaping the future of science!
From interdisciplinary innovation to pioneering methods & major scientific contributions โ€” we honored early-career researchers pushing the boundaries:๐Ÿงต

02.07.2025 13:48 โ€” ๐Ÿ‘ 21    ๐Ÿ” 4    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 1
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Structural heterogeneity and dynamics in the apical stem loop of s2m from SARS-CoV-2 Delta by an integrative NMR spectroscopy and MD simulation approach Abstract. In structured RNAs, helical elements are often capped by apical loops that are integral structural elements, ranging from 3 toย >20 nts of size

New publication in @narjournal.bsky.social - Using NMR, SAXS & MD, we characterize the dynamic nonaloop of the SARS-CoV-2 Delta s2m RNA, contributing to future ensemble-functional studies of dynamic RNA motifs.

Full text: doi.org/10.1093/nar/...

#RNA #StructuralBiology #NAR #NMR #MDSimulations

01.07.2025 06:57 โ€” ๐Ÿ‘ 8    ๐Ÿ” 3    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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Can AI build a virtual cell? Scientists race to model lifeโ€™s smallest unit Several groups hope to develop artificial-intelligence models that can predict how cells behave.

www.nature.com/articles/d41... #heartmusclecells :)

28.06.2025 20:52 โ€” ๐Ÿ‘ 2    ๐Ÿ” 1    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0
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We are very happy to invite you to our 9th Rhineland RNA Club at @dzne.science Bonn with great local speakers and Lena Steckelberg @lenasteckelberg.bsky.social as our invited speaker. All #RNA enthusiasts are welcome! Organized by @inahuppertz.bsky.social and @katleppek.bsky.social. #RNAsky

24.06.2025 16:56 โ€” ๐Ÿ‘ 12    ๐Ÿ” 6    ๐Ÿ’ฌ 1    ๐Ÿ“Œ 1

@goetheuni.bsky.social @rheinmainunis.bsky.social @mpibp.bsky.social @mpibrain.bsky.social #FIAS

25.06.2025 12:15 โ€” ๐Ÿ‘ 1    ๐Ÿ” 0    ๐Ÿ’ฌ 0    ๐Ÿ“Œ 0

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