Genes with low-to-intermediate pleiotropy (1−Tau) drove most transcriptomic changes, specially contributing to the highest levels of parallelism. In contrast, early adaptation involved transient changes in more pleiotropic genes.
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Most transcriptomic trajectories showed a rapid shift followed by a plateau—mirroring fitness changes and supporting the two phases of polygenic adaptation: directional and stabilizing.
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A fast, concordant transcriptomic response revealed thousands of differentially expressed genes across generations.
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Fecundity -a fitness component- increased rapidly over 7 generations, then plateaued suggesting the transition toward an equilibrium.
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Proud to share our new preprint with Neda! @nedabarghi.bsky.social
Using experimental evolution and time-series phenotyping, we reveal the phases of polygenic adaptation driving rapid evolution in large Drosophila populations adapting to a new environment. 👉 www.biorxiv.org/content/10.1...
