Bryan Yipp

Congrats to my friend Nick @jendzjowsky.bsky.social and his team on his R01

Neural anticipation of virtual infection triggers an immune response - Nature Neuroscience Serino et al. show that seeing an infectious avatar approach the body in virtual reality triggers an immune response, indicating that the brain prepares the body to fight infections even for perceived...

www.nature.com/articles/s41...

Scientific publishing needs urgent reform to retain trust in research process | Letters Letters: Readers respond to an article on how too many low-quality papers and journals are being churned out

Scientific publishing needs urgent reform to retain trust in research process | Peer review and scientific publishing | The Guardian share.google/PMJi9Hl7AR3Q...

Neutrophils drive vascular occlusion, tumour necrosis and metastasis - Nature Neutrophils actively induce tumour necrosis, driving vascular occlusion, pleomorphic necrosis and metastasis.

I’m happy to share our latest work on tumour necrosis! During my time in the @megeblad.bsky.social lab, we found that tumour necrosis is not a passive phenomenon secondary to tumour growth, but an active phenomenon driven by neutrophils and NETs! Thread below: (1/13)
www.nature.com/articles/s41...

Thanks Nature Immunology and Dr. Houston for highlighting our work! Neurons protect against fibrosis | Nature Immunology share.google/fptChrZJhgdo...

Pathobiology — Can We Do Without It? | NEJM With changes to preclinical curricula, some medical schools have eliminated certain freestanding subject-based courses, such as histology and pathobiology.

Pathobiology — Can We Do Without It? | New England Journal of Medicine www.nejm.org/doi/full/10....

Neuroinflammation across neurological diseases The brain’s response to injury includes the activation of intrinsic microglia and the influx of leukocytes, collectively constituting neuroinflammation, the “flame” of the brain. Although details diff...

Neuroinflammation across neurological diseases | Science www.science.org/doi/10.1126/...

A fungal-derived adjuvant amplifies the antitumoral potency of Bacillus Calmette-Guérin via reprogramming granulopoiesis While BCG is the standard therapy for bladder cancer, its clinical limitations demand improved strategies. Jurado et al. show that combining BCG with β-glucan reprograms granulopoiesis to generate trained neutrophils with enhanced antitumoral activity, preventing their protumoral conversion and leading to complete tumor eradication and survival. These findings support this dual therapy as a promising immunotherapeutic approach for solid tumors.

Online now: A fungal-derived adjuvant amplifies the antitumoral potency of Bacillus Calmette-Guérin via reprogramming granulopoiesis

A fungal-derived adjuvant amplifies the antitumoral potency of Bacillus Calmette-Guérin via reprogramming granulopoiesis While BCG is the standard therapy for bladder cancer, its clinical limitations demand improved strategies. Jurado et al. show that combining BCG with β-glucan reprograms granulopoiesis to generate tra...

A fungal-derived adjuvant amplifies the antitumoral potency of Bacillus Calmette-Guérin via reprogramming granulopoiesis: Immunity www.cell.com/immunity/ful...

New review from Reglero Real, Rolas, and Nourshargh explores how #aging alters the microvasculature and surrounding stromal cells, disrupting immune cell trafficking and promoting chronic #inflammation. rupress.org/jem/article/...

Nociceptor neurons suppress alveolar macrophage-induced Siglec-F+ neutrophil-mediated inflammation to protect against pulmonary fibrosis Sensory innervation impacts several lung diseases, but whether it influences pulmonary fibrosis (PF) is unclear. Hiroki et al. report that depletion of TRPV1+ nociceptors leads to worsening of inflamm...

Our latest work on how nerves safeguard lung fibrosis. Congrats to Dr. Hiroki and collaborators. @cp-immunity.bsky.social @kavithascranton.bsky.social @hotchkissbrain.bsky.social @ucalgary.bsky.social @ucalgarymed.bsky.social @libininstitute.bsky.social

www.cell.com/immunity/abs...

Kabil, Hughes, McNagny et al. identify a balance between ILC2s & ILC3s as critical for gut tissue repair. Selective deletion experiments reveal that ILC2 loss promotes #fibrosis, while ILC3 depletion protects against it. rupress.org/jem/article/...

#MucosalImmunology #InnateImmunity #inflammation

A study from the #MarraffiniLab in @science.org shows that newly discovered weapons of bacterial self-defense take different approaches to achieving the same goal: preventing a virus from spreading through the bacterial population.

Learn more: bit.ly/4dvmBij

Geoffrey Meissner and the FlyLight Team at @hhmijanelia.bsky.social created this video which shows a progressive rainbow of neurons in the brain of a fruit fly – but this is just a small sampling of the more than 135,000 neurons in a typical fruit fly’s brain.

A collaborative study between the labs of @danmucida.bsky.social and @victora.bsky.social earlier this year showed how immune cells in the gut distinguish between food and harmful pathogens, shedding light on the origins of food allergies: bit.ly/4hyS18b

#FoodAllergyAwarenessWeek

It's #FundamentalDiscoveryWeek and International Awareness Day for Chronic Immunological and Neurological Diseases!

Dr. Bryan Yipp and his lab work at the intersection of immunology, neuroscience, and pulmonary medicine using basic science.

@snyderinstitute.bsky.social @ucalgarymed.bsky.social

YouTube video by Hotchkiss Brain Institute (HBI) Fundamental Discovery Week - Meet Bella, Grace, and Carlos from the Yipp Lab

Meet Bella, Grace, and Carlos—three trainees in the Yipp Lab who are exploring how the nervous and immune systems work together to shape health and disease. #FundamentalDiscoveryWeek

youtube.com/shorts/k5CVw...
@snyderinstitute.bsky.social @bryanyipp.bsky.social @ucalgarymed.bsky.social

YouTube video by Hotchkiss Brain Institute (HBI) Fundamental Discovery Week - Meet Angela, Luke, and Idaira from the Yipp Lab

For #FundamentalDiscoveryWeek, we’re highlighting the work of three emerging leaders in neuro-immunity research: Angela, Luke, and Idaira!

youtube.com/shorts/8xs5k...
@snyderinstitute.bsky.social @bryanyipp.bsky.social @ucalgarymed.bsky.social

Fundamental Discovery Week Celebrating the groundwork of innovationMay 12 - May 18

hbi.ucalgary.ca/research/ins...

Cholinergic T cells revitalize the tumor immune microenvironment: TIME to ChAT - Nature Immunology Tak Mak and colleagues review the role of cholinergic T cells in the tumor immune microenvironment.

www.nature.com/articles/s41...

Day of Immunology is tomorrow! Neuroimmunology-focused events by @iuis-online.bsky.social starting at 9am Eastern Time. Great speaker list and live stream available at immunohub.iuis.org/iuis/2024/webinars/4152027 #dayofimmunology #worldimmunologyday

Cellular and Molecular Mechanisms of Innate Memory Responses | Annual Reviews - www.annualreviews.org/content/jour...

Nerve- and airway-associated interstitial macrophages mitigate SARS-CoV-2 pathogenesis via type I interferon signaling The local immunoregulatory mechanisms that safeguard the host from excessive lung infection inflammation remain unclear. Yeung, Yokota et al. uncover the essential role of nerve- and airway-associated...

Excited to share our latest study
@cp-immunity.bsky.social. Heartfelt thanks to the editorial and review teams , to my co-first @yeungadventures.bsky.social, our co-authors, and to @khannakm.bsky.social
for his outstanding mentorship throughout! Pls read/share!👇
www.cell.com/immunity/ful...

Neural representation of cytokines by vagal sensory neurons - Nature Communications This study showed that vagal sensory neurons in the nodose ganglia selectively encode specific cytokines, enabling real-time body-brain communication of immune signals. This neural encoding of cytokin...

www.nature.com/articles/s41...

Assistant Professor (Research), Department of Microbiology & Immunology, (C2-240724) Please refer to the How to Apply for a Job (for External Candidates) job aid for instructions on how to apply. If you are an active McGill employee (ie: currently in an active contract or position at ...

Do you study host-pathogen interactions and want to start your own research program in a beautiful Canadian city with European flare? Look no further and join us at #McgillUniversity

Apply here!!👇🏼

mcgill.wd3.myworkdayjobs.com/McGill_Caree...

Human Immunity to Fungal Infections. New review from Donald Vinh @donvinh.bsky.social @mcgill.ca: rupress.org/jem/article/...

#InfectiousDisease #HostDefense #HumanDiseaseGenetics #Immunodeficiency

A type 1 immune-stromal cell network mediates disease tolerance against intestinal infection The significant tissue damage imposed by intestinal helminths is controlled by a type 1 immune response. Triggered by the microbiota, gut-resident CD8+ T cells release IFNγ to preserve organ function ...

A type 1 immune-stromal cell network mediates disease tolerance against intestinal infection: Cell www.cell.com/cell/fulltex...

B cells modulate lung antiviral inflammatory responses via the neurotransmitter acetylcholine www.nature.com/articles/s41...

ReThink - The Gene Lay Institute

‼️BIG news ‼️
#ReThinkNeuroimmunology #RTN registration is open and live! The program is amazing!
Hurry up to register while prices are low!
See you in Boston in October!
genelayinstitute.org/rtn/