Conor McCann

Hopefully some of this information is useful for families, clinicians and researchers to demonstrate the ongoing needs of children with Hirschsprung Disease......and highlight the need for new treatments!

Childhood outcomes in children with Hirschsprung disease: a population-based data linkage study in England Objective Hirschsprung disease (HSCR) is a rare congenital intestinal condition that, despite lifesaving surgery, can result in increased hospitalisations and a lower quality of life throughout childh...

Hot on the heels of our recent basic science preprint. Check out our preprint of a data driven study looking at Hirschsprung Disease Outcomes of children in England using ECHILD (medrxiv.org/cgi/content/...).

Functional and molecular rescue of aganglionic colon by human enteric nervous system progenitor transplantation in Hirschsprung disease Hirschsprung disease (HSCR) is a devastating congenital disorder characterised by absence of the enteric nervous system (ENS) in the distal gut. Cell therapy, using human pluripotent stem cell-derived...

Check out our lab’s new preprint (www.biorxiv.org/content/10.1...) on the consequences of ENS progenitor transplantation to mouse Hirschsprung disease explants. Delighted to continue a fruitful collaboration with
@tsakiridis.bsky.social
to develop a #celltherapy for #Hirschsprungs

For the fourth year running, our INSPIRE Programme (hdbi.org/inspire) is welcoming A-level students to @uclchildhealth.bsky.social this week. This has been possible thanks to Wellcome Trust and Human Developmental Initiative funding, and all our volunteers. #workexperience #childheath #research

New preprint from our group on bioRxiv, a little step towards a better understanding of how coordinated contractions develop in the human intestine. Please check it out and let us know your thoughts.

Second (BBSRC Yorkshire Bioscience DTP-funded) PhD project available in our lab (jointly with
@christoseland.bsky.social) examining how biomechanical cues crosstalk with signals to influence cell fate decisions during hESC differentiation. More details here: thenode.biologists.com/jobs/funded-...