Diego U. Ferreiro

"Probing the Dark Energy in the Functional Protein Universe" is now published in @pnas.org 🎉

www.pnas.org/doi/10.1073/...

22.01.2026 19:09 — 👍 6    🔁 4    💬 0    📌 0

Our method for predicting folding dynamics/mechanisms from sequence info is now a book chapter! link.springer.com/book/9781071...

@diegulise.bsky.social

06.11.2025 12:12 — 👍 1    🔁 1    💬 0    📌 0

Maybe @sokrypton.org and @lindorfflarsen.bsky.social find it usefull?

12.08.2025 14:57 — 👍 2    🔁 0    💬 0    📌 0

Probing the Dark Energy in the Functional Protein Universe We show how to localize and quantify the functional evolutionary constraints on natural proteins. The method compares the perturbations caused by local sequence variants to the energetics of the prote...

❗New Preprint w/ C Bueno (‪@cabb99.bsky.social‬), IE Sánchez (@nachoquique.bsky.social‬), PG Wolynes & DU Ferreiro (@diegulise.bsky.social‬)

We define the Protein Dark Energy and use it to localize and quantify the functional evolutionary constraints on natural proteins

arxiv.org/abs/2508.08109

12.08.2025 14:49 — 👍 12    🔁 5    💬 1    📌 2

Why are there 20 amino acids and 4 nucleotides? Evolution of folded biopolymers requires effective and fast search of both the conformational space for folding and the sequence space for evolution. Molecular information theory and energy landscape theory show that the alphabet size of extant proteins and RNA is just enough to fulfill these requirements, given the constraints posed by the chemical physics of these polymers. Empirical estimations of the size of the effective sequence and conformational spaces of natural biopolymers support the theoretical predictions.

En ciencia no hay preguntas pequeñas, pero igualmente divierte investigar con @diegulise.bsky.social y Ezequiel Galpern por qué hay 20 aminoácidos en las proteínas y 4 nucleótidos en el ARN doi.org/10.1590/SciE...

13.01.2025 18:47 — 👍 3    🔁 3    💬 1    📌 0