bioRxiv Genomics

Motif-Centered Analyses Elucidate Mutagenic Mechanisms Operating in Normal Human Tissues https://www.biorxiv.org/content/10.1101/2025.10.07.681015v1

Multi-platform framework for mapping somatic retrotransposition in human tissues https://www.biorxiv.org/content/10.1101/2025.10.07.680917v1

Spatial genomics of the cardiac sarcomere https://www.biorxiv.org/content/10.1101/2025.10.07.680947v1

Splicing Isoforms Associated to TGFb-Induced Myofibroblast Activation https://www.biorxiv.org/content/10.1101/2025.10.06.680821v1

Systematic identification of genomic non-response biomarkers to cancer therapies https://www.biorxiv.org/content/10.1101/2025.10.06.680777v1

The plastid genome of the non-photosynthetic plant Rhopalocnemis phalloides is one of the most polymorphic genomes known https://www.biorxiv.org/content/10.1101/2025.10.06.680833v1

SURFR: genome-free discovery of cancer-unique small RNAs from cohort sequencing data https://www.biorxiv.org/content/10.1101/2025.10.07.680618v1

Early Invasion Genomic Resources for Xenia umbellata (Native to the Red Sea) and its Associated Dinoflagellate Symbionts in Puerto Rico https://www.biorxiv.org/content/10.1101/2025.10.03.680359v1

Taming the reference genome jungle: the refget sequence collection standard https://www.biorxiv.org/content/10.1101/2025.10.06.680641v1

Complex HPV-human DNA structures revealed by large-scale DNA analyses in an HPV-cancer derived cell line https://www.biorxiv.org/content/10.1101/2025.10.06.680684v1

Genomic Population Structure of the Sunda Pangolin (Manis javanica) in Thailand: Implications for Conservation and Wildlife Forensics https://www.biorxiv.org/content/10.1101/2025.10.06.680665v1

Clonal dynamics of monozygotic twinning in early human embryogenesis https://www.biorxiv.org/content/10.1101/2025.10.05.680569v1

High-Resolution Characterization of rAAV Genomes for Vector Quality Using Long-Read Sequencing https://www.biorxiv.org/content/10.1101/2025.10.05.680573v1

RawBench: A Comprehensive Benchmarking Framework for Raw Nanopore Signal Analysis Techniques https://www.biorxiv.org/content/10.1101/2025.10.04.680405v1

Pan-cancer analysis reveals context-dependent roles of LINE-1 ORF1p in immune regulation and copy number alterations https://www.biorxiv.org/content/10.1101/2025.10.03.680361v1

Protamine lacunae preserve the paternal chromatin landscape in sperm https://www.biorxiv.org/content/10.1101/2025.10.03.680364v1

Influence of cis-regulatory elements on regulatory divergence in human segmental duplications https://www.biorxiv.org/content/10.1101/2025.10.03.680410v1

Postnatal maternal care impacts hypothalamic Esrrg gene expression, co-expression profiles, and the DNA methylome in prenatal bisphenol-exposed rats https://www.biorxiv.org/content/10.1101/2025.10.03.680379v1

Parallel polygenic urban adaptation despite high gene flow in a coastal marine invertebrate https://www.biorxiv.org/content/10.1101/2025.10.03.680100v1

The genetic architecture of trabecular bone score and association with fracture: a genome-wide association and meta-analysis https://www.biorxiv.org/content/10.1101/2025.10.01.678241v1

Persistent hindrances to data re-use in single-cell genomics https://www.biorxiv.org/content/10.1101/2025.10.02.680150v1

Integrative multi-omics uncovers skeletal muscle enhancer programming of cardiorespiratory fitness https://www.biorxiv.org/content/10.1101/2025.10.02.679855v1

Antimicrobial resistance and comparative genome analysis of high-risk Escherichia coli clones isolated from Egyptian children with diarrhoea. https://www.biorxiv.org/content/10.1101/2025.10.02.680073v1

SpliceDecoder: A High-Throughput Tool for Guiding the Functional Interpretation of Differential Splicing Events https://www.biorxiv.org/content/10.1101/2025.10.01.679902v1

Are Different Populations Fairly Represented in Single-Cell Omic Atlases? https://www.biorxiv.org/content/10.1101/2025.10.01.677375v1

Latent plasticity of the human pancreas across development, health, and disease. https://www.biorxiv.org/content/10.1101/2025.10.01.679230v1

The ongoing invasion of the endogenous retrovirus Kuruka in natural Drosophila melanogaster populations https://www.biorxiv.org/content/10.1101/2025.10.01.679930v1

Poising and connectivity of emergent human developmental enhancers in the transition from naive to primed pluripotency https://www.biorxiv.org/content/10.1101/2025.10.02.679816v1

The RNA-binding protein NOVA-1 regulates circRNA expression, alternative splicing, and aging in C. elegans https://www.biorxiv.org/content/10.1101/2025.10.02.679314v1

Photolabile oligonucleotides combined with topologically imposed light gradients enable spatially resolved single-cell transcriptomics and epigenomics https://www.biorxiv.org/content/10.1101/2025.10.01.679703v1