Elaine Emmerson

Pathology & Translational Advances in Salivary Gland Disease, a talk with Dr. McCoy and Dr. Warner

As we gain organisational momentum for the 2027 #exocrine #glands #gordonconference, our GRS chairs have been preparing #podcasts. Listen now for a great discussion around #immunology, #pathology & #translation from Sarah McCoy & Blake Warner.
open.spotify.com/episode/1Lhs...

The boys’ club: How Epstein’s influence shaped the exclusion of women in STEM In one email, an AI researcher suggested it’s “hard to be brilliant if you are worrying if you look fat or why another woman hates you.”

Women's voices have been curiously absent from the media coverage of the Epstein files. Kudos to @jkutzie.bsky.social for publishing this excellent piece. If you consider yourself to be an ally please take a moment to consider the impact of the ecosystem created by men at the top.

When you share an office with the queen of the #axolotls (aidarodrigo.bsky.social) you also get to share the birthday joy! 🥳 Happy 2nd birthday to the OG axolotls (treats baked by Laura Arbanas and @cellysally.bsky.social’s daughter)

Our latest preprint, led by @lizihegarty.bsky.social & aided by @erinwatson.bsky.social shows that fixation time matters when it comes to visualising #macrophages in #salivarygland & other epithelia.We find 1hr allows detection of mac subsets while preserving architecture. With @bainlab.bsky.social

Targeting macrophages to protect fertility after chemotherapy at University of Edinburgh on FindAPhD.com PhD Project - Targeting macrophages to protect fertility after chemotherapy at University of Edinburgh, listed on FindAPhD.com

🧫 For anyone interested in doing a #PhD in #fertility preservation, #chemotherapy & #macrophages please see this opportunity at @edinuni-irr.bsky.social in #Edinburgh, supervised by Roseanne Rosario, @rodtmitchell.bsky.social & me.

💻 www.findaphd.com/phds/project...

📆 Closing date: 6th March

What is happening with UKRI funding and the STFC cuts? - CaSE In recent days there have been a number of reports about cuts to UKRI budgets and grant funding pauses. Here we summarise events so far, and set out why we believe UKRI should explain how and why deci...

In recent days there have been a number of reports about cuts to UKRI budgets and grant funding pauses.

www.sciencecampaign.org.uk/analysis-and...

Parliamentlive.tv Science, Innovation and Technology Committee

Some thoughts on the select committee appearance by the boss of UKRI, Ian Chapman yesterday. It’s a long watch but can be seen here: parliamentlive.tv/Event/Index/...
Thread 🧵

Targeting Post‐Irradiation Thyroid Dysfunction: Electrospun Scaffolds As A Dual‐Action Approach for Antioxidant and Immune Modulation Radiation-induced hypothyroidism follows head and neck radiotherapy due to oxidative stress and inflammation. Electrospun polycaprolactone scaffolds containing adenosine have potential to modulate th...

V happy to share the latest collaborative effort between myself & Anthony Callanan, led by #PhDstudent Mary Heim, who characterised #macrophages in the irradiated #thyroid, and then developed electrospun scaffolds to locally modulate immune response.
advanced.onlinelibrary.wiley.com/doi/10.1002/...

Immune cells adapt to distinct stem cell niches to govern tissue homeostasis https://www.biorxiv.org/content/10.64898/2026.01.28.701831v1

Very nice commentary of @lizihegarty.bsky.social’s recent paper in @mucosalimmunol.bsky.social by Florent Ginhoux and colleagues #macrophage #colon @bainlab.bsky.social

Great commentary of Fredi & @selmatuzlak.bsky.social’s Nature Immunology #adenophage paper, written by @steffenjung.bsky.social and colleagues.

www.nature.com/articles/s41...

Adenophages are an atypical macrophage population in exocrine glands sustained by ILC2-derived GM-CSF - Nature Immunology Here the authors identify adenophages, a previously unknown macrophage population present in exocrine glands in mice and humans. These cells are dependent on ILC2-derived GM-CSF and support glandular ...

This collab started when I met Fredi at the 2023 #EMDS meeting. Since then it’s been wonderful working with her, @selmatuzlak.bsky.social & Burkhard to explore these GM-CSF dependent #macrophages in #glands. Delighted to see this published in @natimmunol.nature.com 🥳

www.nature.com/articles/s41...

Great to see #ECRs chairing sessions at @britsocimm.bsky.social #BSI25! Here’s our postdoc @lizihegarty.bsky.social excellently co-chairing the #neuroimmunology session alongside Jessica Teeling.

Tissue resident colonic macrophages persist through acute inflammation and adapt to aid tissue repair in this work from @lizihegarty.bsky.social, @bainlab.bsky.social, and colleagues: www.mucosalimmunology.org/article/S193...

Tripotent Lgr5 stem cells in the posterior tongue generate lingual, taste, and salivary gland lineages - Nature Communications Here, the authors show that a single Lgr5 stem cell population in the posterior tongue produces taste buds, salivary glands, and epithelium, representing unified chemosensory units.

A common LGR5+ cell gives rise to the #tongue epithelium, the #tastebuds and the von Ebner #salivaryglands. A lovely study from @hansclevers.bsky.social and colleagues.

www.nature.com/articles/s41...

If you work with #scRNAseq, #salivary, #thyroid or #mammary gland #organoids, or are interested in #irradiation and #Notch signaling, you might find this exciting! Our latest paper is now available in @embojournal.org! Check it out! Link below ✨

doi.org/10.1038/s443...

IFN-I signaling enhances salivary gland stem and progenitor cell activity after irradiation Regenerative responses in salivary gland organoids after irradiation are mediated by IFN-I signaling.

Extremely excited to see this out in @science.org Signaling! In this study, we explored the molecular differences between #photon and #proton irradiation and uncovered how #salivary gland stem cells respond to the resulting #inflammatory cues.

www.science.org/doi/10.1126/...

Intestinal blood vessel-associated macrophages and gut-vascular barrier dysfunction in cirrhosis Background Bacterial translocation in cirrhosis can trigger infection and hepatic decompensation, leading to systemic inflammation, organ failure and increased mortality. These infections often origin...

Delighted to share this! We identify gut #macrophages as key players in preventing dissemination of intestinal microbes in liver cirrhosis. Best collab with my partner in crime @lenasmets.bsky.social, featuring some stunning live imaging with @colindascheele.bsky.social
👇
gut.bmj.com/content/earl...

Tissue resident colonic macrophages persist through acute inflammation and adapt to aid tissue repair Macrophages are crucial for the maintenance of intestinal homeostasis, are considered key proinflammatory effector cells during intestinal inflammatio…

Thrilled for our wonderful postdoc @lizihegarty.bsky.social whose #PhD work on colonic #macrophages and #colitis with @bainlab.bsky.social @edinuni-irr.bsky.social has been accepted for publication in @mucosalimmunol.bsky.social 🔬

www.sciencedirect.com/science/arti...

Conserved signals control self-organization and symmetry breaking of murine bilayered epithelia during development and regeneration Journot et al. explore fate specification during embryonic development and regeneration of bilayered glandular epithelia. They uncover conserved molecular mechanisms linking tissue architecture with c...

A beautiful study describing cell fate acquisition in bilayered #epithelia, inc. my fave #salivarygland, published in @cp-devcell.bsky.social

Conserved signals control self-organization & symmetry breaking of murine bilayered epithelia during development & regeneration

www.cell.com/developmenta...

CCR2-driven monocyte recruitment is protective against radiotherapy-induced intestinal toxicity Radiotherapy (RT) is essential in treating abdominal and pelvic cancers but often damages the healthy tissues, particularly the intestines, leading to…

Wonderful to see this lovely data out in @mucosalimmunol.bsky.social! Congratulations to @nabinapun.bsky.social, @douglaspdyer.bsky.social & colleagues of @lydiabeckeriii.bsky.social & @mcrcellmatrix.bsky.social! 👏
#monocyte #radiotherapy #intestinal #toxicity
www.sciencedirect.com/science/arti...

A young man standing in front of Old College, Edinburgh University.

A young man standing next to a banner with the words “Advocating for parents and carers in STEMM” written on it.

Nice to spend the morning in the magnificent Playfair Library at @edinburgh-uni.bsky.social discussing how to better support #carers in #STEMM, organised by @carersinstemm.bsky.social, and with my very own dependent alongside me as it’s half term!

Frontiers | Salivary gland macrophages in health and disease: heterogeneity, niche crosstalk, and therapeutic avenues Salivary glands (SGs) produce saliva essential for digestion, mucosal immunity, and as a source of non-invasive biomarkers. The health and pathology of SGs h...

📖 A very comprehensive review of the heterogeneity, crosstalk and therapeutic potential of #salivarygland #macrophages including reference to several papers from @emmersonlab-irr.bsky.social
📚 #immunosky
www.frontiersin.org/journals/imm...

Sensory neurons shape local macrophage identity via TGF-β signaling Specialized macrophages are known to persist within tissue niches, but the molecular mechanisms guiding their sustained functional adaptation remain unclear. Kolter and Döring et al. show that local i...

TGFb mediates #macrophage specialisation and crosstalk with sensory #nerves in the #skin after injury. A beautiful study by Julia Kolter, Philipp Henneke and colleagues published in @cp-immunity.bsky.social #immunosky

www.cell.com/immunity/ful...

John Gurdon John Gurdon is at the Wellcome Trust/Cancer Research UK Institute of Cancer and Developmental Biology in Cambridge. Educated at Eton and Christ Church, Oxford, he changed from classics to zoology. Dur...

“For Gurdon to continue in biology would be a complete waste of time both for him and for those who would have to teach him”

He proved them wrong! RIP John Gurdon

www.cell.com/current-biol...

Great to see this out for all to see after a lot of hard work by @lizihegarty.bsky.social and @bainlab.bsky.social. Colonic #macrophages persist but are transcriptionally altered post- #inflammation in a mouse model of #colitis.

Absolutely delighted that our superstar #postdoc @lizihegarty.bsky.social was awarded the @cmvm-edinburghuni.bsky.social Student Support & Supervision Award for #PAW 2025. Thoroughly deserved for everything she does for @emmersonlab-irr.bsky.social, @bainlab.bsky.social & @edinuni-irr.bsky.social

A cracking meal complete with piper & Ceilidh to round off the second day of #EMDS2025 in #Edinburgh

#EMDS2025 attendees - if anyone is looking for a postdoc position and likes what they see of #Edinburgh, please come and speak to me or @lizihegarty.bsky.social (poster 71) or @erinwatson.bsky.social (poster 35).

After a year of planning, we are ready.

Registration opens at 8am. Excited for 2.5days of great science and a bit of fun.

See you soon