Aging Science News

Principles of protein abundance regulation across single cells in a mammalian tissue Protein synthesis and clearance are major regulatory steps of gene expression, but their in vivo regulatory roles across the cells comprising complex tissues remains unexplored. Here, we systematicall...

Principles of protein abundance regulation across single cells in a mammalian tissue
www.biorxiv.org/content/10.1...

New (and provocative) piece with David Gems 🚨

Extending healthspan rather than lifespan should not be the goal of aging research.

Rather, our goal is to understand and intervene in aging to improve late-life health and save of lives: i.e. life-extension.

www.preprints.org/manuscript/2...

The dissipation theory of aging: a quantitative analysis using a cellular aging map - npj Aging npj Aging - The dissipation theory of aging: a quantitative analysis using a cellular aging map

The dissipation theory of aging: a quantitative analysis using a cellular aging map
www.nature.com/articles/s41...

Glucagon receptor signaling is indispensable for the healthspan effects of caloric restriction in aging male mice - GeroScience Obesity and type 2 diabetes mellitus accelerate aging, shortening the duration of healthspan. Conversely, chronic calorie restriction (CR) extends healthspan. Research aimed at understanding the mecha...

Glucagon receptor signaling is indispensable for the healthspan effects of caloric restriction in aging male mice
link.springer.com/article/10.1...

Evidence for improved DNA repair in long-lived bowhead whale - Nature Analysis of the longest-lived mammal, the bowhead whale, reveals an improved ability to repair DNA breaks, mediated by high levels of cold-inducible RNA-binding protein.  &nbs...

Evidence for improved DNA repair in long-lived bowhead whale
www.nature.com/articles/s41...

Multi-omic profiling reveals age-related immune dynamics in healthy adults - Nature This multi-omic longitudinal analysis of the healthy human peripheral immune system constructs the Human Immune Health Atlas and assembles data on immune cell composition and state changes w...

Multi-omic profiling reveals age-related immune dynamics in healthy adults
www.nature.com/articles/s41...

Telomerase Depletion Accelerates Ageing of the Zebrafish Brain
onlinelibrary.wiley.com/doi/full/10....

Living healthily to 120: Implications for entrepreneurship Research on how to slow, halt, and reverse aging processes is making progress. Pharmaceutical, big-tech, and venture capital companies and their owner…

Living healthily to 120: Implications for entrepreneurship
www.sciencedirect.com/science/arti...

Rapalink-1 reveals TOR-dependent genes and an agmatinergic axis-based metabolic feedback regulating TOR activity and lifespan in fission yeast - Communications Biology A study using fission yeast reveals that rapalink-1 extends lifespan and identifies new anti-ageing proteins, including all agmatinase enzymes. Agmatinases are shown to modulate growth through the reg...

Rapalink-1 reveals TOR-dependent genes and an agmatinergic axis-based metabolic feedback regulating TOR activity and lifespan in fission yeast
www.nature.com/articles/s42...

Protein restriction reprograms the multi-organ proteomic landscape of mouse aging Comprehensive proteomic analysis of 41 mouse tissues reveals tissue-specific aging hallmarks and demonstrates that dietary protein restriction mitigates age-related molecular changes, improves adipose...

Protein restriction reprograms the multi-organ proteomic landscape of mouse aging
www.cell.com/cell/abstrac...

Association of Epigenetic Age Acceleration and Mitochondrial DNA‐Based Aging Metrics Provides Insights Into Mechanisms of Aging‐Related Diseases Older participants exhibit lower mtDNA copy number (CN) and a higher rare heteroplasmy burden, while common heteroplasmy burden remains relatively stable. Higher epigenetic age acceleration is associ...

Association of Epigenetic Age Acceleration and Mitochondrial DNA-Based Aging Metrics Provides Insights Into Mechanisms of Aging-Related Diseases
onlinelibrary.wiley.com/doi/full/10....

Epigenetic Clocks: Beyond Biological Age, Using the Past to Predict the Present and Future <p>Predicting health trajectories and accurately measuring aging processes across the human lifespan remain profound scientific challenges. Assessing the effectiveness and impact of interventions targ...

Epigenetic Clocks: Beyond Biological Age, Using the Past to Predict the Present and Future
www.aginganddisease.org/EN/10.14336/...

Herbal terpenoids activate autophagy and mitophagy through modulation of bioenergetics and protect from metabolic stress, sarcopenia and epigenetic aging - Nature Aging Using a zebrafish-based screen, Civiletto and colleagues identify the herb-derived metabolites thymol and carvacrol as activators of autophagy and mitophagy, demonstrating their therapeutic potential ...

Herbal terpenoids activate autophagy and mitophagy through modulation of bioenergetics and protect from metabolic stress, sarcopenia and epigenetic aging
www.nature.com/articles/s43...

Protein Catabolites as Blood‐Based Biomarkers of Aging Physiology: Findings From the Dog Aging Project The Dog Aging Project identifies protein catabolites as biomarkers of age and aging physiology in the Precision Cohort of companion dogs across the United States.

Protein Catabolites as Blood-Based Biomarkers of Aging Physiology: Findings From the Dog Aging Project
onlinelibrary.wiley.com/doi/full/10....

Frontiers | Circadian system and aging: where both times interact Time shapes life both through its steady progression, as seen in aging, and through its eternal return, reflected in biological rhythms. These two temporal f...

Circadian system and aging: where both times interact
www.frontiersin.org/journals/agi...

Lilly invests in epigenetic reprogramming biotech NewLimit adds $45m in new funding at a $1.6bn valuation following preclinical progress that brings clinical trials closer to reality.

Lilly invests in epigenetic reprogramming biotech
longevity.technology/news/lilly-i...

Decoding sexually dimorphic proteomic landscapes in the context of aging and mortality - Communications Medicine Jin, Du et al. develop a proteomic-based aging clock, called ProteAge, designed to estimate biological age and predict mortality risk using proteomics data from the UK Biobank. Findings reveal clear s...

Decoding sexually dimorphic proteomic landscapes in the context of aging and mortality
www.nature.com/articles/s43...

What’s counted counts: the implications of underrepresentation for the application of epigenetic clocks in diverse populations - Clinical Epigenetics DNA methylation (DNAm) has been touted as a potential unified marker of the contributions of both inherited and environmental factors on an individual’s health. Changes in DNAm have been associated wi...

What’s counted counts: the implications of underrepresentation for the application of epigenetic clocks in diverse populations
clinicalepigeneticsjournal.biomedcentral.com/articles/10....

Ubiquitin precursor with C-terminal extension promotes proteostasis and longevity Altin et al. identified CxUb, a C-terminally extended ubiquitin molecule dedicated to overcoming stress and present in all eukaryotic genomes. CxUb marks client proteins for efficient degradation by t...

Ubiquitin precursor with C-terminal extension promotes proteostasis and longevity
www.cell.com/molecular-ce...

Two-phase model of ageing in mice for improved identification of age-related and late life metabolic decline - BMC Biology Living animals reach their end-of-life through a stereotypic set of fascinating but poorly understood processes. The discovery, first in flies and later in nematodes and zebrafish, of the “Smurf pheno...

Two-phase model of ageing in mice for improved identification of age-related and late life metabolic decline
bmcbiol.biomedcentral.com/articles/10....

The impacts of chronic infections on shaping cellular senescence - Immunity & Ageing Cellular senescence is a fundamental biological process characterized by stable cell cycle arrest, genomic instability, and the acquisition of a proinflammatory secretory phenotype. While senescence i...

The impacts of chronic infections on shaping cellular senescence
immunityageing.biomedcentral.com/articles/10....

The secreted metabolite sensor CtBP2 links metabolism to healthy lifespan - Nature Aging Sekiya and colleagues identify that, in response to reductive metabolism, CtBP2 is secreted via exosomes and regulates metabolism in recipient cells via CYB5R3 and AMPK. Exosomal CtBP2 administration ...

The secreted metabolite sensor CtBP2 links metabolism to healthy lifespan
www.nature.com/articles/s43...

Organ‐Specific Dedifferentiation and Epigenetic Remodeling in In Vivo Reprogramming Transient in vivo expression of Yamanaka factors (OSKM) enhances regenerative competence and rejuvenation across multiple tissues. We highlight mechanistic links between injury-induced dedifferentiat...

Organ-Specific Dedifferentiation and Epigenetic Remodeling in In Vivo Reprogramming
onlinelibrary.wiley.com/doi/full/10....

Evidence for an energetic trade-off model linking inflammaging and immunosenescence in the US Health and Retirement Study and UK Biobank Later life is characterized by the development of chronic inflammation, termed inflammaging, alongside changes in immune cell profiles, or immunosenescence. While these features contribute to health r...

Evidence for an energetic trade-off model linking inflammaging and immunosenescence in the US Health and Retirement Study and UK Biobank
www.biorxiv.org/content/10.1...

Biological age estimation using circulating blood biomarkers - Communications Biology An improved biological age estimation machine learning model uses readily available blood biomarkers, offering a practical and cost-efficient method of estimating biological age with pre-existing clin...

Biological age estimation using circulating blood biomarkers
www.nature.com/articles/s42...

Translating cellular senescence research into clinical practice for metabolic disease - Nature Reviews Endocrinology This Review explores the translation of senotherapeutics into clinical practice for metabolic disorders. The authors discuss the relationship between metabolic disorders and cellular senescence, curre...

Translating cellular senescence research into clinical practice for metabolic disease
www.nature.com/articles/s41...

Developing and applying computational methods to study ageing and cellular rejuvenation at University of Birmingham on FindAPhD.com PhD Project - Developing and applying computational methods to study ageing and cellular rejuvenation at University of Birmingham, listed on FindAPhD.com

PhD studentship available in our lab to study ageing, longevity and cellular rejuvenation using computational methods and machine learning/AI.

Applications are open to UK and international students.

Deadline: 27 November 2025.

www.findaphd.com/phds/project...

The role of cellular senescence in cardiovascular disease - Cell Death Discovery Cell Death Discovery - The role of cellular senescence in cardiovascular disease

The role of cellular senescence in cardiovascular disease
www.nature.com/articles/s41...

Niche-specific dermal macrophage loss promotes skin capillary ageing - Nature Capillary-associated macrophages are selectively lost over time, contributing to impaired vascular repair and reduced tissue perfusion in older mice.

Niche-specific dermal macrophage loss promotes skin capillary ageing
www.nature.com/articles/s41...

Age Deceleration and Reversal Gene Patterns in Dauer Diapause The dauer diapause is a naturally occurring extraordinarily long-lived alternative C. elegans larval stage that, upon dauer exit, lives a normal adult life with full reproductive capacity. Here, we d....

Age Deceleration and Reversal Gene Patterns in Dauer Diapause
onlinelibrary.wiley.com/doi/full/10....