Karl Carlström

Our study on neuroblastoma developmental plasticity is the cover story in the latest issue of Dev. Cell @cp-devcell.bsky.social .The Chinese-ink Taiji (Yin–Yang) cover to echo cell-state transitions. Huge thanks to the editors, co-authors. #Neuroblastoma www.cell.com/developmenta...

A few weeks ago, I had to discuss about DynaTag, a smart tweak to CUT&Tag that enables single-cell transcription factor mapping with just a buffer change.
Opening a number of future avenues.
📰 Via
@GenomeWeb
: lnkd.in/djYm_sGg
#epigenetics #singlecell

Min vän Jovan har startat cykelverkstad i Gubbängens centrum cykelnomad.com. Blev en räddad palm som inflyttningspresent. Vi jobbade tillsammans för 10 år sedan och han har jobbat heltid som cykelmekaniker sen dess. Sprid gärna ordet så han kommer igång ordentligt!

David Baltimore, Nobel-Winning Molecular Biologist, Dies at 87

Of David's countless accomplishments is the important work that Matt Porteus did in his lab on early-stage genome editing with engineered nucleases (pubmed 12730593).
He and Matt both speak about this in the documentary "Human Nature."
A true titan.
www.nytimes.com/2025/09/07/s...

Balancing off-target and on-target considerations for optimized Cas9 CRISPR knockout library design The continued development of high-dimensional CRISPR screen readouts, such as single-cell RNA sequencing and high-content imaging, necessitates compact libraries to enable functional interrogation at ...

Doomscrolling pause to chat CRISPR libraries! Preprint describes our new, data-driven approach to combine on-target and off-target predictions much more intelligently for *selecting* guides, which we use to develop our newest Cas9 knockout library, Jacquere. Thread: www.biorxiv.org/content/10.1...

Metformin alters mitochondria-related metabolism and enhances human oligodendrocyte function Nature Communications - Metformin is under clinical trial for brain neuroprotection but how it may work is poorly understood. Here, the authors show that metformin helps myelin formation by human...

Our new paper on metformin, myelin, mitochondria and metabolism is now out at rdcu.be/eDbFD
Thanks to Nina and all of the team!

A careful, comprehensive and creative characterization of T cell dynamics in response to pathogens, with all credits going to @rohamparsa.bsky.social who just opened his lab!

Excited to share our new preprint! We studied how T cells are functionally & clonally shaped across organs over time. With the new TRACK mice, we genetically label recently activated T cells with tdTomato and track their migration across tissues. #immunology #science www.biorxiv.org/content/10.1...

Cecilia Uddén: ”Som journalist ska du vara opartisk – men objektiv kan ingen vara” Cecilia Uddén har hamnat i fokus för debatten om journalistik och opartiskhet.

Träffade SR:s Mellanösternkorrespondent Cecilia Uddén och pratade om Gaza, opartisk journalistik och sorgen efter hennes kärlek Elisabet Ohlson.

Deadline (September 2) approaching! Join us and start your lab at @ki.se!

LINE-1 retrotransposons mediate cis-acting transcriptional control in human pluripotent stem cells and regulate early brain development Adami et al. demonstrate that evolutionarily young L1s are expressed in human pluripotent stem cells and are dynamically regulated throughout neural differentiation. The study examines the role of L1s...

New paper from our lab! We found that LINE-1 transposons contribute to early human brain development.

Funded by @asapresearch.parkinsonsroadmap.org

www.cell.com/cell-genomic...

DN Debatt. ”Därför slutar jag som statsepidemiolog” Statsepidemiologen Magnus Gisslén berättar i debattartikel att han tappat sitt förtroende för Folkhälsomyndigheten

www.dn.se/debatt/darfo...

I am hiring an halftime administrative assistant for my lab! we are fun dynamic group located in Bonn DZNE. Pls Spread the word.
Learn more & apply
karriereamukb.de/jobs/teamass...

Kennedys stopp för mRNA-forskning är en present till antivaxxare Kennedys pengastopp till mRNA-forskning i USA riskerar att hindra medicinska framsteg. Dessutom ger han antivaxxare ännu fler skäl att misstro myndigheter.

Tillbaka i tjänst och första texten handlar naturligtvis om RFK jr. Det är svårt att ignorera allt som han gör och förstör. (Premium, men kan läsas om man har en prenumeration på någon Bonnier-titel via Plus allt)

Join us at the FENS Single-Cell & Spatial Omics Winter School with:

@sarabiz86.bsky.social
@rongfan8.bsky.social
@gokcegroup.bsky.social
@gioelelamanno.bsky.social
@sj-marzi.bsky.social
@jplopez-atalaya.bsky.social
Ana Falcão
Florian Rosenberger
Gabriel Baró
Bosiljka Tasic
Barbara Treutlein

The creative process in science has a set of thinking tools that we could do a better job teaching. Here are the 12 articles that Martin and I wrote about them, including "It takes two to think", "A hypothesis is a liability" and "The two languages of science". night-science.org/home/learn/r...

Image credit: @gloglita.bsky.social‬ @lifescienceeditors.bsky.social‬ captured DynaTag in action: a pA-Tn5 probe (multicoloured) binds an antibody (white), which binds p53 DNA-binding domain (green) on DNA (blue) within 2 nucleosomes

🧪Move over CUT&Tag, there’s a new #TranscriptionFactor mapping method in town.
Our newly developed DynaTag is faster, cleaner, more sensitive than #ChIPseq, #CUT&RUN and #CUT&Tag.
🔗 Our @natcomms.nature.com paper: www.nature.com/articles/s41...
🧵Let’s break down what makes DynaTag so powerful (1/7)

1/16 New pre-print from the Sternberg Lab!
We uncover how temperate phages can use RNA-guided transcription factors to remodel the flagellar composition of their bacterial host and enhance their fitness.
Find the preprint and full story here: tinyurl.com/mshwjd77

Herregud vad uselt chefredaktören på DN svarar. Det är så pinsamt, så skamligt. Återigen: ingen av alla dessa medlöpare och självpåtagna censorer som bidragit till att folkmordet har fått fortgå ohejdat ska någonsin få glömma det.

12th Dev Brains:

@junyuecao.bsky.social @alainchedotal.bsky.social
@cecilecharrier.bsky.social
@trayon.bsky.social
Isabel Espinosa-Medina
Beatriz Rico
Michael Ziller
Dwight Bergles

news.ki.se/calendar/dev...

@hjerling-leffler.bsky.social
@ulrikakmarklund.bsky.social
@flallemend.bsky.social

@carlstrom.bsky.social Clemens Ries, and Ting Sun rocking at #GLIA2025! And the launch of the Carlström lab!

Neuron programming! Pro-neural TFs + 480 morphogen conditions + scRNA-seq --> Diverse iN subtypes of forebrain, midbrain, hindbrain, spinal cord, and PNS. @hsiuchuanlin.bsky.social‬ @jasperjanssens.bsky.social‬ and Treutlein Lab! @science.org www.science.org/doi/10.1126/... #NGN2 #ASCL1

On now, last session of #Glia2025, and last presenter from the lab.

S26 | Exploring glial diversity using single cell and spatial genomics
@mrodea.bsky.social
10:00 S26-01 Multi-omic definition of astrocyte diversity in the healthy and inflamed brain

'Positive review only': Researchers hide AI prompts in papers Instructions in preprints from 14 universities highlight controversy on AI in peer review

This is insane! "'Positive review only': Researchers hide AI prompts in papers"
asia.nikkei.com/Business/Tec...
h/t Ryan Pack

#GLIA2025 is in full swing!
We’re halfway through an exciting week full of energy, ideas, and exchange.
Highlights so far:
🎓 Stipend Award Session
🧠 Poster Sessions
🤝 Welcome Reception

Let’s keep the momentum going!

#GliologistsTogether

And for the poster session II at #EuroGlia the French Glial Cell Club is still present!

I am super happy that we have had so many visitors at the booth. #gliaRules #glia2025

What a start to #GLIA2025!
We kicked off with an inspiring Opening Ceremony, our first lively Poster Session, and a warm Welcome Reception.
The day ended with great conversations at the Peripheral Glia Social at The Black Stone.

More to come – stay tuned!

If you're attending @gliameeting.bsky.social #glia2025 check out Lucy Ryan's talk in the trainee symposia (17) on Thursday & poster T14-001A on heterogeneity of oligodendrocyte pathology in Alzheimer's disease!