Zampieri Lab

The Parkinson’s drug benztropine possesses histamine receptor 1-dependent host-directed antimicrobial activity against Mycobacterium tuberculosis - npj Antimicrobials and Resistance npj Antimicrobials and Resistance - The Parkinson’s drug benztropine possesses histamine receptor 1-dependent host-directed antimicrobial activity against Mycobacterium tuberculosis

We discussed in our past journal club how Benztropine, a Parkinson’s drug, limits intracellular mycobacterium tuberculosis growth by modulating host histamine receptor H1, highlighting histamine signalling as a host-directed target.

www.nature.com/articles/s44...

Universität Basel: PhD position in systems biology (Zampieri Lab) The Department of Biomedicine is a joint effort between the University of Basel and the University Hospitals Basel. It unites basic and clinical scientists to advance our understanding of health and d...

The Zampieri Lab at the University of Basel is recruiting a highly motivated PhD candidate to investigate how metabolic programs drive cancer metastasis.
📩 Only applications submitted through the official recruiting system of the University of Basel will be considered.
jobs.unibas.ch/offene-stell...

Home - Zampieri Lab By studying fundamental mechanisms regulating short- and long-term metabolic adaptation to genetic and chemical perturbations, our lab aims at finding new and unconventional therapeutic strategies, fr...

We have multiple open positions in our lab (www.zampierilab.org). Interested candidates should apply through the University of Basel’s official recruitment portal:
www.unibas.ch/en/Working-a...

Universität Basel: Internship Opportunity (100%) Zampieri Lab The Department of Biomedicine is a joint effort between the University of Basel and the University Hospitals Basel. It unites basic and clinical scientists to advance our understanding of health and d...

🎉 We’re excited to announce that Laurentz has been awarded the Research Fund for Excellent Junior Researchers 2025 of the University of Basel.

As part of this project, we are now looking for a motivated intern: jobs.unibas.ch/offene-stell...

After our hike up the hills in Pratteln, we had a lovely evening out at Wystübli Leuengrund, enjoying a lot of 🧀 fondue and local wine 🥂.

Impressive and interesting talks this week from our lab at the DBM monthly seminar series!

Sebastian Bors and Tobias Fuhrer presented their projects and preliminary results, illustrating our lab's efforts to combine large screens with cell culture and high-throughput metabolomics.

Fructose and glucose from sugary drinks enhance colorectal cancer metastasis via SORD - Nature Metabolism Feng, Luo and colleagues show that the combination of glucose and fructose, as found in sugar-sweetened beverages, promotes colorectal cancer metastasis through a mechanism involving sorbitol dehydrog...

In this week’s journal club, we discussed how sugar-sweetened beverages - America’s sweetest legacy - may drive colorectal cancer metastasis. Glucose + fructose relieve CRC cells from NAD+ limitation through SORD to boost metastasis.

www.nature.com/articles/s42...

A shared alarmone–GTP switch controls persister formation in bacteria - Nature Microbiology Alarmone synthesis depletes GTP levels leading to a GTP-dependent switch that controls triggered, spontaneous and antibiotic-induced persister formation in Bacillus subtilis.

In our recent journal club, we discussed an impressive paper published in Nature Microbiology titled “A shared alarmone–GTP switch controls persister formation in bacteria”. A comprehensive work on a (p)ppGpp–GTP antagonism pathway!

Check it out:
doi.org/10.1038/s415...

We are happy to welcome Charleen Braun, doing her Master’s degree in Bioanalytics at Coburg University of Applied Sciences with a specialization in Human Biology.

At our annual Summer Symposium, Laurentz Schuhknecht from our Lab received this year’s DBM Research Prize, for his groundbreaking work in drug discovery and systems pharmacology, published in Nature Biotechnology (Nature Portfolio) earlier this year.
biomedizin.unibas.ch/en/communica...

The role of metabolism in shaping enzyme structures over 400 million years - Nature By combining structural biology and evolutionary genomics analyses, the evolution of enzymes over 400 million years is shown to be governed by catalytic function, metabolic network architecture, cost ...

In our today's journal club, we discussed this impressive work by the Ralser Lab appearing this month in Nature:

www.nature.com/articles/s41...

In-cell NMR reveals metabolic adaptations in central carbon pathways driving antibiotic tolerance in Salmonella Typhimurium Antibiotic tolerance presents a significant challenge in eradicating bacterial infections, as tolerant strains can survive antibiotic treatment, contributing to the recurrence of infections and the de...

In our recent journal club, we discussed insights obtained by in vivo NMR in the context of antibiotic resistance.

Check it out!

pubs.rsc.org/en/content/a...

We are happy to welcome Sandra Pflästerer, doing her Master’s degree in Molecular and Cellular Biology at Ludwig-Maximilian University.

Macrophages recycle phagocytosed bacteria to fuel immunometabolic responses - Nature Phagocytosed bacteria can serve as an alternative nutrient source for macrophages, influencing their metabolic and immune responses through the recycling of microbial components, with the process regu...

In our recent journal club, we discussed a nice publication from Nature: “Macrophages recycle phagocytosed bacteria to fuel immunometabolic responses”. These exciting findings open the door to approaches that regulate immunometabolism during bacterial infections.

www.nature.com/articles/s41...

Home - Zampieri Lab By studying fundamental mechanisms regulating short- and long-term metabolic adaptation to genetic and chemical perturbations, our lab aims at finding new and unconventional therapeutic strategies, fr...

We are looking for highly motivated Master and Bachelor Students to work on computational projects to better understand how bacteria and cancer cells metabolically adapt to chemical perturbations. Write us and find out how to conduct your semester or master project in our lab!

www.zampierilab.org

The glutamine-aspartate metabolic tradeoff between fast growth and metabolic flexibility. Cancer cells develop unique addictions to nutrients offering attractive opportunities for clinical intervention. However, how cancer cells orchestrate and benefit from metabolic rewiring remain fundam...

We are happy to share our new work on glutamine addiction in cancer cells. By characterizing the exchange rate and dynamic metabolite response to extracellular glutamine deprivation, we shed light on long standing questions about glutamine addiction.

www.biorxiv.org/content/10.1...

A warm welcome to Dana Reddmann, Biochemistry Master's student at Freie Universität Berlin, starting her Master Thesis in our lab!

We are happy to welcome Elena Pintea, MSc-Student in the Drug Sciences program at the University of Basel.

Same Drug, New Actions: Metabolomics Reveals Hidden Drug Effects Studying drug-induced metabolic changes with high-throughput systems shed light on drug modes of action, providing an efficient drug discovery platform.

Our recent publication has been featured in The Scientist! Thanks to Sneha Khedkar for such a clear and exciting presentation of our research.

www.the-scientist.com/same-drug-ne...

A systematic survey of TF function in E. coli suggests RNAP stabilization is a prevalent strategy for both repressors and activators Abstract. Transcription factors (TFs) are often classified as activators or repressors, yet these context-dependent labels are inadequate to predict quanti

In today's journal club, we discussed the work by Sunil Guharajan, Vinuselvi Parisutham and Robert C. Brewster from @brewsterlab.bsky.social, which was recently published in Nucleic Acids Research.

doi.org/10.1093/nar/...

A warm welcome to Thomas Gosselin-Monplaisir, visiting PhD-Student from Toulouse Biotechnology Institute.

We are seeking for a talented semester or master student for a computational project on antimicrobial effects of drugs. Check it out!

www.zampierilab.org/join-us/

Mapping metabolite disturbances by drugs High-throughput metabolomic profiling gives insight into unpredictable drug effects

Our work was featured in chemistryworld. Fantastic pitch of our research by Anthony King.

www.chemistryworld.com/news/mapping...

Aspartate signalling drives lung metastasis via alternative translation - Nature Aspartate in the tumour environment activates the N-methyl-d-aspartate receptor in cancer cells to induce cellular programmes that increase the aggressiveness of metastasis.

Today in our journal club: impressive work by the group of S.M. Fendt KU Leuven, published in Nature:

www.nature.com/articles/s41...

Here they present how elevated pulmonary aspartate levels trigger a translational program that boosts the aggressiveness of lung metastases.

A human metabolic map of pharmacological perturbations reveals drug modes of action - Nature Biotechnology Mapping the metabolic effects of drugs helps define their mode of action.

We are very excited to share that the recent research from our lab has been published in Nature Biotechnology!

Thanks to our lab members and our collaborators for contributing to this project and especially to Laurentz for driving this exciting research!
www.nature.com/articles/s41...

Gut microbiota regulates stress responsivity via the circadian system Gut microbes are known to modulate stress responsivity and behavior. Tofani et al. demonstrate that such modulations occur via the circadian system. The oscillations in gut microbiota composition regu...

Today in our journal club: impressive work by Tofani et al. in Cell Metabolism. www.cell.com/cell-metabol...

This is our new lab profile on @bsky.app ! Stay tuned for regular news and updates from our lab!