My Brain Finally Broke Much of what we see now is fake, and the reality we face is full of horrors. More and more of the world is slipping beyond my comprehension.

www.newyorker.com/culture/the-...

23andMe files for bankruptcy protection The company said that it will now attempt to sell itself under the supervision of a court.

Now might be a good time to protect your data if you’ve used this service.

www.bbc.com/news/article...

French researcher denied entry to US for 'expressing personal opinion' on Trump policies France's research minister expressed 'concern' on Wednesday at this decision by the US authorities. The researcher underwent a random check on arrival, before his computer and phone were searched, a s...

www.lemonde.fr/en/internati...

Beyond the black box with biologically informed neural networks Nature Reviews Genetics, Published online: 04 March 2025; doi:10.1038/s41576-025-00826-1Biologically informed neural networks promise to lead to more explainable, data-driven discoveries in genomics, drug development and precision medicine. Selby et al.…

ICYMI: New online! Beyond the black box with biologically informed neural networks

Postdocs in Epidemiology or Statistical Genetics at The Pioneer Centre for SMARTbiomed - Vacancy at Aarhus University Vacancy at Department of Public Health - NCRR - National Centre for Register-based Research, Aarhus University

We're hiring Pioneer Fellow Postdocs!!

Join us at the Pioneer Centre for SMARTbiomed to develop innovative methods in epidemiology, biostatistics, and statistical genetics, working with big biomedical data.

international.au.dk/about/profil...

#StatGen #Epi #Postdoc #SMARTbiomed

Exclusive: NIH to terminate hundreds of active research grants Studies that touch on LGBT+ health, gender identity and DEI in the biomedical workforce could be terminated, according to documents obtained by Nature.

www.nature.com/articles/d41...

📢 New #FederatedEGA paper out: "The Federated European Genome–Phenome Archive as a global network for sharing human genomics data"

📍 Published in Nature Genetics
🔗 www.nature.com/articles/s41...

📣📣Genomic data sharing: you don’t know what you’ve got (till it’s gone) www.nature.com/articles/s41...

A comment @natrevgenet.bsky.social from @katholt.bsky.social and me

Trans-ancestry genome-wide study of depression identifies 697 associations implicating cell types and pharmacotherapies Trans-ancestry GWAS of major depression identifies 697 genetic variants and 308 genes, implicating neural and molecular mechanisms and drug repurposing opportunities.

New study from the @pgcgenetics.bsky.social:

Multi-ancestry GWAS of MDD in over half a million cases and 4 million controls.

www.cell.com/cell/fulltex...

Genomics yields biological and phenotypic insights into bipolar disorder - Nature Using multi-ancestry genome-wide association study and fine-mapping, 298 loci and 36 credible genes are identified in the aetiology of bipolar disorder.

The PGC just published the largest multi-ancestry #GWAS of #BipolarDisorder, identifying 298 genetic regions linked to the condition. go.nature.com/3PJhi3W 2/5

Modern GWAS can identify 1000s of significant hits but it can be hard to turn this into biological insight. What key cellular functions link genetic variation to disease?

I'm very excited to present our new work combining associations and Perturb-seq to build interpretable causal graphs! A 🧵

FlexLMM: a Nextflow linear mixed model framework for GWAS https://academic.oup.com/bioinformatics/advance-article/doi/10.1093/bioinformatics/btaf021/7954687 🧬🖥️🧪 https://github.com/birneylab/flexlmm

We're living George Orwell's 1984: IGNORANCE IS STRENGTH.

What's Happening Inside the NIH and NSF

A long post about what’s happening to the science funding agencies in the US and why. As mentioned, this one just kept getting longer even as I kept stripping curse words from it.

www.science.org/content/blog...

BREAKING NEWS: CDC orders mass retraction and revision of submitted research across all science and medicine journals. Banned terms must be scrubbed. Any unpublished manuscript mentioning certain topics, including gender and "LGBT," must be pulled or revised.

BREAKING NEWS: CDC orders mass retraction and revision of submitted research across all science and medicine journals. Banned terms must be scrubbed.

Goes beyond MMWR +other CDC pubs. Applies to research already submitted to top medical journals.

Take a look.
open.substack.com/pub/insideme...

Trump ousts at least 15 independent inspectors general in late-night purge The dismissals appeared to violate federal law, which requires Congress to receive 30 days’ notice of any intent to fire a Senate-confirmed inspector general.

Corruption 101: Clear out the cops before you send in the thieves. www.washingtonpost.com/politics/202...

Heritable polygenic editing: the next frontier in genomic medicine? www.nature.com/articles/s41...

Provocative but quantitative analysis from Peter Visscher, Julian Savulescu and co.

Confronting the “Weaponization” of Genetics by Racists Online and Elsewhere Genomics research is regularly appropriated in social and political contexts to publicly legitimize unjust and malicious political views, policies, and actions. In recent years, there have been high-....

"... the forces of racism have regrouped on the borders of legitimate science and transformed themselves into a dynamic and creative citizen science movement capable of exploiting features of human genetics... human geneticists need to contend with the evolving practices of this ... movement"

La Fondation des Treilles, un lieu virgilien pour les arts et la pensée Dans « un paysage du bout du monde » situé dans le Haut Var, la Fondation des Treilles est un lieu qui favorise le dialogue entre créateurs et chercheurs.

Thanks to Les Treilles Fondation (www.fondationdestreilles.com) for hosting us for a wonderful retreat to discuss causal inference in genetics with Charles Assad, Brielin Brown, @judithabk6.bsky.social, Anne Rovsing, Matti Pirinen,Marie Verbanck,Xiang Zhou,Chiara Sabatti, and Sriram Sankararaman...

The dpt started a new Primer Method session! The meeting will take place every Monday for 2 months. Today we had @hu-asch.bsky.social discussing interaction effect testing in linear models. Next week @yoann.bsky.social will talk about computing, storing and querying de Bruijn Graph from k-mer!

Scientific seminars are resuming at full speed in the dpt. We'll have two great speakers in September: @florencebansept.bsky.social on Sept 26 to discuss Host-associated microbial communities, and Ahmed Elkoussy
on Sept 27 to talk about single cell and spacial genomics data analysis!