Inyoung Jeong (Jung)

Preprint -
Excited to present WHOLISTIC, which extends the concept of whole-brain functional imaging to the entire body. Pioneering work by incredibly talented Virginia Ruetten @vmsruetten.bsky.social, this platform reveals whole-organism cellular dynamics in vivo.
www.biorxiv.org/content/10.1...

Hierarchical processing of sensory information across topographically organized thalamocortical-like circuits in the zebrafish brain Thalamocortical projections contribute to the spatial organization and functional hierarchies of the mammalian cortex. Primary sensory cortices receive topographically segregated information from firs...

New very cool work from the Yaksi lab:

Hierarchical processing of sensory information across topographically organized thalamocortical-like circuits in the zebrafish brain

www.biorxiv.org/content/10.1...

Advection versus diffusion in brain ventricular transport - Fluids and Barriers of the CNS Cerebrospinal fluid (CSF) is integral to brain function. CSF provides mechanical support for the brain and helps distribute nutrients, neurotransmitters and metabolites throughout the central nervous ...

🚩Publication Alert🚩"Advection vs. Diffusion in Brain Ventricular Transport" by Herlyng at al in collaboration with @utropstegn.bsky.social at @simularesearch.bsky.social and Jebsen Centre for Brain Fluid Research is now published in Fluids and Barriers of the CNS! 🧠💧

Inhibition mediated by group III metabotropic glutamate receptors regulates habenula activity and defensive behaviors Nature Communications - The role of glutamate-driven inhibition in neural computations and animal behavior is not fully understood. This study reveals that group III metabotropic glutamate...

New publication from our lab is just out! rdcu.be/ezk1U
In brief, we showed that glutamate-driven inhibition in the habenula can alter neural activity and connectivity, leading to amplified sensory responses and defensive behaviors.

Our paper on zebrafish phenotypes in Alzheimer’s risk genes finally is now in its final form at Elife!

With everything that's going on, I needed this cool data 1 day before #flourescencefriday. It's my first time with #GCaMP imaging (green), and you can clearly see Aβ42 induced hyperexcitability at the same time that we also see BBB leakage (not shown)! #zebrafishrock

Glymphatics and meningeal lymphatics unlock the brain-immune code Recent discoveries of glymphatics and meningeal lymphatics have redefined our understanding of CNS immunosurveillance. Kim and Kipnis illustrate how the clearance of brain-derived antigens creates an “immune code” that, when presented by meningeal antigen-presenting cells, instructs T cells to safeguard neural homeostasis. They review how inflammation, aging, and neurodegeneration disrupt this finely tuned process and highlight emerging therapeutic opportunities.

Online now: Glymphatics and meningeal lymphatics unlock the brain-immune code

Redefining CNS immune privilege - Nature Reviews Immunology In this Perspective, Smyth and Kipnis reappraise the concept of immune privilege in the central nervous system. Although immune privilege was originally thought to involve isolation of the central ner...

Our perspective in @natrevimmunol.nature.com on new concepts in neuroimmune interactions that have challenged the old dogma that immune privilege is a result of the isolation of the nervous and immune systems.

@jonykipnis.bsky.social
www.nature.com/articles/s41...

Redefining CNS immune privilege Nature Reviews Immunology - In this Perspective, Smyth and Kipnis reappraise the concept of immune privilege in the central nervous system. Although immune privilege was originally thought to...

Free link below: rdcu.be/ekqtw

Reverse engineering the control law for schooling in zebrafish using virtual reality Reverse engineering the control law used by schooling fish provides an effective and robust algorithm for robotic pursuit.

Liang Li and team have developed a VR system for fish to decipher how they school. The team uncovered the natural ‘control law’ used by zebrafish to coordinate behavior with others.

@icouzin.bsky.social @uni-konstanz.de @cbehav.bsky.social

Paper: www.science.org/doi/10.1126/...

I am very happy to contribute this amazing story. In this paper, I generated a genetic tool to trace CSF proteins in the brain ventricles in a noninvasive way. See below and it works very well!!

Advection versus diffusion in brain ventricular transport Cerebrospinal fluid (CSF) is integral to brain function. CSF provides mechanical support for the brain and helps distribute nutrients, neurotransmitters and metabolites throughout the central nervous ...

Preprint alert: 🧠🌊🦓-🐟
Have you ever wondered how molecules move around the brain?
Check out our latest preprint led by Halvor Herlyng from the team of Marie Rognes @utropstegn.bsky.social at @simularesearch.bsky.social and us at NTNU.
www.biorxiv.org/content/10.1...

1/35 New paper out! @jamesTstroud and I dive into why long-term studies are crucial for understanding evolution. They reveal processes impossible to detect in short timescales and capture rare events that transform our understanding of evolutionary dynamics.

www.nature.com/articles/s41...

Synthesis pathway of placozoan monoamine receptor agonists compared to the acetylated versions of the compounds that activate human melatonin receptors

New insights into neurotransmitter evolution from a GPCR screen in Trichoplax, a neuron-less animal.

with Yanez-Guerra et al.
https://www.biorxiv.org/content/10.1101/2025.04.18.649542v1

Trichoplax has tryptamine, tyramine, and phenethylamine receptors […]

[Original post on biologists.social]

Thanks a lot for posting it, @zebrafishrock.bsky.social!!
The choroid plexus is a major cerebrospinal fluid (CSF) producing tissue in the brain.

The evolutionarily conserved choroid plexus contributes to the homeostasis of brain ventricles in zebrafish Jeong et al. show that the zebrafish choroid plexus has conserved anatomical features with mammals and expresses transporters involved in cerebrospinal fluid secretion. By using chemogenetics, they re...

You can learn more about the choroid plexus in this original research paper from the Jeong and the @nathaliejuya.bsky.social group: www.cell.com/cell-reports...

Depth-coded and pseudocolored image of the choroid plexus in a zebrafish brain. This tissue produces cerebrospinal fluid.

The choroid plexus in the zebrafish brain. Credit to @inyoungj88.bsky.social. #ZebrafishZunday 🧪

Anatomical and Molecular Characterization of the Zebrafish Meninges https://www.biorxiv.org/content/10.1101/2025.04.09.646894v1

“These findings support the use of zebrafish as a useful comparative model for studying the meninges, provide a foundational description for future zebrafish meningeal research”

New work from @biomarina-vg.bsky.social & Weinstein Lab at NIH 🐟

Motile cilia modulate neuronal and astroglial activity in the zebrafish larval brain The brain uses a specialized system to transport cerebrospinal fluid (CSF), consisting of interconnected ventricles lined by motile ciliated ependymal…

Have you ever wondered what role motile #cilia and cerebrospinal fluid (#CSF) play in brain development and physiology? If yes, please check out our latest article now published in Cell Reports and spearheaded by the newly minted Dr D'Gama www.sciencedirect.com/science/arti...

Join us in beatiful Barcelona !!!

"Maximizing mutagenesis with solubilized CRISPR-Cas9 ribonucleoprotein complexes" Alexa Burger and the Mosimann Lab

Did you know: #zebrafish coined the term "crispant" in this 2016 paper (in a wink to the morpholino counterparts "morphants") #ZebrafishFunFacts 🧪

The movement of brain ependymal #cilia was first described by Purkinje in 1836.

Purkinje JE (1836) Ueber Flimmerbewegungen im Gehirn. Archiv für Anatomie, Physiologie und Wissenschaftliche Medicin (Müller) Jahrgang 1836, pp 289–291 […]

[Original post on biologists.social]

Group Leader Positions (Researcher I, code 1110) (270380) | University of Bergen Job title: Group Leader Positions (Researcher I, code 1110) (270380), Employer: University of Bergen, Deadline: Sunday, December 15, 2024

We are hiring Group Leaders! One month left to apply ⏳ Join us in beautiful Bergen for a chance to lead exciting science in a supportive environment! 🌊
🔗 tinyurl.com/4bwn8u3n