Andrew Vo

Brain size links neurodevelopment to neurodegeneration in Parkinson's disease Genetic studies have advanced our understanding of Parkinson's disease (PD) pathogenesis, establishing a role for autophagy and lysosomal dysfunction. However, how genetic risk translates into neurona...

Cortical expansion and genetic risk for PD.
Led by Houman Azizi and Nooshin Abbasi.
With @ptenigma.bsky.social @misicbata.bsky.social @yasharneuro.bsky.social @ndrewvo.bsky.social and many others www.medrxiv.org/content/10.6...

Why does your brain shrink in Parkinson’s? Word shrink in this case refers to measurable loss of brain tissue (atrophy), which reflects thinning of cortex/loss of volume in key brain regions. New paper shows widespread atrophy following brain’s wiring diagram and local biological vulnerabilities.

Being an academic means 25% of your time is spent approving 2FA requests and resetting your password for journal portals 😑

New preprint. @ndrewvo.bsky.social‬ and @enigmabrains.bsky.social‬ analyzed MRI of > 3,000 people with Parkinson’s disease. W-score method to compare PD to matched controls confirmed extensive loss of cortical thickness, surface area and subcortical volumes in PD, even in early stages

Convergent large-scale network and local vulnerabilities underlie brain atrophy across Parkinson's disease stages: a worldwide ENIGMA study https://www.medrxiv.org/content/10.1101/2025.05.25.25326586v1

how long before this thing descends into the dumpster fire that is/was academic twitter? 🫣