Carsten Korth

Molecular Precision Psychiatry. How schizophrenia subset identification leads to a tailored animal model, biomarkers and precise pharmacotherapy

www.nature.com/articles/s41...

Molecular Precision Psychiatry. How schizophrenia subset identification leads to a tailored animal model, biomarkers and precise pharmacotherapy

www.nature.com/articles/s41...

"our precision psychiatry approach: the biological definition of a subset of schizophrenia by identifying DISC1 protein aggregates, the generation of a corresponding animal model and a successful pharmacotherapy of a clinically relevant phenotype"

www.nature.com/articles/s41...

"our precision psychiatry approach: the biological definition of a subset of schizophrenia by identifying DISC1 protein aggregates, the generation of a corresponding animal model and a successful pharmacotherapy of a clinically relevant phenotype"

www.nature.com/articles/s41...

Oxidized MIF is an Alzheimer’s disease drug target relaying external risk factors to tau pathology

cell.com/cell-reports...

Oxidized MIF is an Alzheimer’s disease drug target relaying external risk factors to tau pathology

cell.com/cell-reports...

Alzforum: Phospho-Tau Might Take Down Viruses - But how does HSV-1 elicit increased tau phosphorylation and aggregation?

alzforum.org/news/researc...

Potent novel anti-Herpes Simplex Virus 1 drug:
• Effective in human brain organoids
• Targeting macrophage migration inhibitory factor (MIF)
• Rescuing viral cytotoxicity and induced tau protein pathology in vitro and in vivo

www.cell.com/cell-reports...

Potent novel anti-Herpes Simplex Virus 1 drug:
• Effective in human brain organoids
• Targeting macrophage migration inhibitory factor (MIF)
• Rescuing viral cytotoxicity and induced tau protein pathology in vitro and in vivo

www.cell.com/cell-reports...

Prof. Dr. Carsten Korth (rechts) und Dr. Andreas Müller-Schiffmann (links) vom Institut für Neuropathologie (UKD) in ihrem Labor. - Copyright HHU

Veröffentlichung in Cell Reports Medicine: Besseres Verständnis von Alzheimer-Risikofaktoren
Forschenden der Heinrich-Heine-Universität Düsseldorf (HHU) und des Universitätsklinikums Düsseldorf (UKD) ist es erstmals gelungen nachzuweisen, ...
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Oxidized MIF is an Alzheimer’s disease drug target relaying external risk factors to tau pathology Müller-Schiffmann et al. identify oxidized MIF as a molecular hub relaying the effects of external stressors (e.g., infection with HSV-1) to cellular pathology associated with sporadic Alzheimer’s disease. Small-molecule compound PAV-174/ PAV-617 revert oxidized MIF and contingent tau phosphorylation and aggregation independent of viral infection in vitro and in vivo.

Online now: Oxidized MIF is an Alzheimer’s disease drug target relaying external risk factors to tau pathology

Protein aggregates are analogous to the wreckage after a car crash at an unmarked intersection. Placement of a stop sign is more effective than calling more tow trucks. Antibodies clean up the wreckage, but do not prevent future car crashes. This installs🛑https://shorturl.at/RtKWK

Protein aggregates are analogous to the wreckage after a car crash at an unmarked intersection. Placement of a stop sign is more effective than calling more tow trucks. Antibodies clean up the wreckage, but do not prevent future car crashes. This installs🛑https://shorturl.at/RtKWK

Oxidized MIF is an Alzheimer’s disease drug target relaying external risk factors to tau pathology Müller-Schiffmann et al. identify oxidized MIF as a molecular hub relaying the effects of external stressors (e.g., infection with HSV-1) to cellular pathology associated with sporadic Alzheimer’s dis...

"OxMIF participates in a host-viral interface connecting HSV-1 infection, and possibly other external stressors, with tau cellular pathology"

Oxidized MIF is an Alzheimer’s disease drug target relaying external risk factors to tau pathology: Cell Reports Medicine www.cell.com/cell-reports...

Oxidized MIF is an Alzheimer’s disease drug target relaying external risk factors to tau pathology Müller-Schiffmann et al. identify oxidized MIF as a molecular hub relaying the effects of external stressors (e.g., infection with HSV-1) to cellular pathology associated with sporadic Alzheimer’s dis...

"OxMIF participates in a host-viral interface connecting HSV-1 infection, and possibly other external stressors, with tau cellular pathology"

Oxidized MIF is an Alzheimer’s disease drug target relaying external risk factors to tau pathology: Cell Reports Medicine www.cell.com/cell-reports...

Phosphorylated tau exhibits antimicrobial activity capable of neutralizing herpes simplex virus 1 infectivity in human neurons - Nature Neuroscience The authors found that the Alzheimer’s disease-associated protein tau, widely considered pathogenic when hyperphosphorylated, has a natural function as part of the innate immune system in the brain an...

www.nature.com/articles/s41...

Psilocybin triggers an activity-dependent rewiring of large-scale cortical networks Psilocybin reshapes brain networks through activity-dependent plasticity, including a weakening of recurrent cortical loops that could underlie its therapeutic effects.

Psilocybin triggers an activity-dependent rewiring of large-scale cortical networks: Cell www.cell.com/cell/fulltex...

Linking gut microbiota rhythmicity to circadian maturation in infants - Scientific Reports Scientific Reports - Linking gut microbiota rhythmicity to circadian maturation in infants

"These results highlight the increasing synchronization between gut microbiota rhythmicity and sleep-wake cycles during infancy,..."

www.nature.com/articles/s41...

New today in @Nature: your visual cortex contains touch-based body maps. bit.ly/VisualBodyMaps
Your brain transforms what you see into first-person, body-referenced codes: A previously unknown bridge between vision and touch.

If the AI bubble bursts, what will it mean for research? The rise in artificial-intelligence technologies is unprecedented, but some predict a stock-market crash that could have knock-on effects for funding and jobs.

www.nature.com/articles/d41...

<em>Neuropathology and Applied Neurobiology</em> | BNS Journal | Wiley Online Library Proteomics of laser-dissected lipofuscin from aged, healthy brains reveals Palmitoyl-Protein Thioesterase 1 (PPT1) and other CLN proteins as constituents. PPT1 is increasingly sequestered to lipo...

"we present an in situ proteome analysis of age-associated human brain lipofuscin that ... reveals PPT1 protein as one major constituent ...It remains to be demonstrated whether PPT1's ... sequestration to lipofuscin leads to ... functional impairments"

onlinelibrary.wiley.com/doi/10.1111/...

Enhanced replication of a contemporary avian influenza A H9N2 virus in human respiratory organoids H9N2 is currently the second most common avian influenza A virus subtype infecting humans. Monitoring viral phenotypic and genotypic adaptation to humans is crucial for risk assessment. Here, we co...

www.tandfonline.com/doi/full/10....

Social Reward Learning Deficits and Concordant Brain Alterations in Rats Overexpressing Disrupted-in-Schizophrenia 1 (DISC1) Social deficits are a hallmark of schizophrenia, often characterized by impairments in processing and integrating socially transmitted information. However, translational models that accurately captur...

@sfnjournals.bsky.social , @hhu.de , @ckorth.bsky.social , @socforneuroecon.bsky.social , @sfn.org , @decisionneurop.bsky.social
#neuroscience #schizophrenia #sociallearning #social #socialneuroscience #neuroeconomics

doi.org/10.1523/JNEU...

Life Lessons from (Very Old) Bowhead Whales

www.nytimes.com/2025/10/29/s...

Our paper is out:
"Palmitoyl-Protein Thioesterase 1 (PPT1) Protein, Linked to Neuronal Ceroid Lipofuscinosis 1, Is a Major Constituent of Ageing-Related Human Neuronal Lipofuscin"
where we identify the proteome of human brain hippocampal lipofuscin
onlinelibrary.wiley.com/doi/10.1111/...

Our paper is out:
"Palmitoyl-Protein Thioesterase 1 (PPT1) Protein, Linked to Neuronal Ceroid Lipofuscinosis 1, Is a Major Constituent of Ageing-Related Human Neuronal Lipofuscin"
where we identify the proteome of human brain hippocampal lipofuscin
onlinelibrary.wiley.com/doi/10.1111/...

Our paper is out:
"Palmitoyl-Protein Thioesterase 1 (PPT1) Protein, Linked to Neuronal Ceroid Lipofuscinosis 1, Is a Major Constituent of Ageing-Related Human Neuronal Lipofuscin"
where we identify the proteome of human hippocampus lipofuscin
onlinelibrary.wiley.com/doi/10.1111/...

Disruption to the gut microbiome by non-antibiotics is linked to infection risk Human-targeted drugs alter the composition and function of the gut microbiome, but their effect on the risk of gastrointestinal infection has received little attention. In two studies, Grieβhammer et ...

Disruption to the gut microbiome by non-antibiotics is linked to infection risk: Cell Chemical Biology www.cell.com/cell-chemica...

JCI Insight - Human pegivirus alters brain and blood immune and transcriptomic profiles of patients with Parkinson’s disease insight.jci.org/articles/vie...

Social Reward Learning Deficits and Concordant Brain Alterations in Rats Overexpressing Disrupted-In-Schizophrenia 1 (DISC1) Social deficits are a hallmark of schizophrenia, often characterized by impairments in processing and integrating socially transmitted information. However, translational models that accurately captur...

our paper is out:
"social impairments may stem from a fine-grained circuit-selective dysfunction rather than generalized reward processing deficit. The tgDISC1 rat is a translational platform for probing the neural substrates of social dysfunction in psych. dis."

www.jneurosci.org/content/earl...