John Tsang

Picture of some of our amazing workshop presenters.

Thank you #CZBiohubNY Mini Workshop presenters and attendees! Great talks by @czbiohub.bsky.social and @yaleschoolofmed.bsky.social scientists. Grateful to #CZI and @tsanglab.bsky.social for bringing us together. Thank you Susan Rosenthal, Elizabeth Ferris and Lital Manor for superb event logistics.

Exciting lineup at today's #CZBiohubNY Mini Workshop hosted by @yalemedicine.bsky.social, @tsanglab.bsky.social and @yalecsei.bsky.social. Thrilled to welcome @czbiohub.bsky.social and @chanzuckerberg.bsky.social investigators and team members to Yale for this day of science and interaction.

What an amazing work @iannaconelab.bsky.social &friends just out @natimmunol.nature.com, it was really cool to have a preview of this fantastic work at the 2025 ENII EFIS EJI Summer School! Many congrats Matteo &co! Check it out here 👉 www.nature.com/articles/s41... & here 😉 👇👇👇

So important! Please contact your Republican senators, especially Sen. Susan Collins (R-ME), Sen. Shelley Moore Capito (R-WV), Sen. Bill Cassidy (R-LA), Sen. Katie Britt (R-AL), and Sen. Dave McCormick (R-PA). 🙏 amplify!

Congrats, Tomer!

Added a bunch of new folks. Let me know if anyone wants to be added.

A systems immunology analysis of Alzheimer’s disease reveals an age- and environmental exposure-independent disturbance in B cell maturation Alzheimer’s disease is a severe neurodegenerative disorder, with multifactorial mechanisms of disease development and progression. Evidence from genetic association studies, animal models, and clinica...

Pre-print time! Our new study on #systemsimmunology analysis of #Alzheimers patients is out now on @medrxivpreprint.bsky.social.

This is the culmination of a long collaboration with Rik Vandenberghe, Stephanie Humblet-Baron and Lidia Yshii's labs at KU Leuven. 🧵1/8

www.medrxiv.org/content/10.1...

Atul Butte’s talk introduced me to systems biology—I was presynapse scientist and opened my horizon to "biomedical moments, thawing frozen discoveries in data". Ideas that changed my career. Thank you for the science, the spirit, and the inspiration. You will be remembered.

Atul has been a constant inspiring force. He is perpetually optimistic and never stops to empower the world with more data and motivate all of us to dig deeper and be more innovative with data. I miss his energy and our conversations. RIP - May memories of Atul continue to inspire us all.

A Review of the President’s Fiscal Year 2026 Budget Request for the National Institutes of Health | United States Senate Committee on Appropriations United States Senate Committee on Appropriations

Senate hearing on the FY26 NIH budget with Jay Bhattacharya
June 10, 10am ET
www.appropriations.senate.gov/hearings/a-r...

FlyBase funding squashed amid Harvard grant terminations The team behind the Drosophila genetics database is now requesting donations from labs to keep the resource afloat.

FlyBase, a crucial resource for drosophila research, has lost its funding because its grant is awarded to Harvard. The team is scrambling to find other sources of funds, including donations from labs. Read more: www.thetransmitter.org/community/fl... @flybase.bsky.social

My colleague and friend @scripps.edu, @ardemp.bskyverified.social, on the NYT front page today

I appreciate the offers from other scientists to help Harvard (students, labs, etc) through this attack, but what would be most helpful is for you to use your position to contact your elected representatives and make it clear this fight isn't just Harvard, it will affect you, and their districts too

YouTube video by Amanpour and Company Breakthrough Prize-Winning Biochemist on the Deadly Cost of Funding Cuts | Amanpour and Company

David Liu @harvard.edu beautifully articulates the criticality of basic science funding for developing revolutionary therapeutics like life-saving base editors 👏

youtu.be/8YhJM6zxYDw?...

All of NIH funding to Northwestern University is frozen. This pause includes noncompeting approved funding, new and competing grants with fundable scores. No reimbursements for money already spent have been received since March. This situation is rarely reported so please Please get the word out!

7/10 In a combined analysis of infants and previously sequenced adults (generated by @tsanglab.bsky.social lab; PMID:33713619), infants display a similar ISG signature in monocytes but a markedly enhanced ISG signature in T and B cells, which is consistent with infant specific immune features.

Exciting study on infant immune responses to sars-cov-2 and how they compare to adults.

1/10 I am very excited to share our latest study, now out in @natcomms.nature.com. We applied a multidimensional approach to decipher the immune responses to SARS-CoV-2 infection in 2-month-old hospitalized infants. We analyzed: scRNA-of PBMCs, serum cytokines and antibody responses. rdcu.be/emkNa

So let me get this straight: masks are bad and un-American if worn to fight a pandemic, but good if worn by people claiming to be government agents when they kidnap people off the street

Wonderful to catch up with friends and colleagues at #aai2025. Ofer Levy, Mercy Prabhudas, Donna Farber, me, and Bali Pulendran. Adding @lucasite-lab.bsky.social in the second one!

Thanks for the highlight! Yes we are live still great talks to come - come on over to hang out with systems immunologists this morning at #aai2025!

My interest in math and science was stimulated by an NSF-funded high school summer program, my PhD dissertation research was supported by an NSF fellowship, and some of my most creative research early in my independent career was supported by an NSF award.

#WithoutNSF

NIH's work saves lives—& Trump is gutting it.

Straight from D.C. I headed to Seattle Children's to hear from researchers & patients alike about the importance of NIH funding—it's not just about lines in a budget, it's about lifesaving discoveries.

We ALL need to speak up to save it.

As always, really enjoyed the science and interactions at #cshlsysimm - a meeting right at the intersection of immunobiology, systems biology, computational modeling, and immune engineering. Great also to catch up with lab alums and so great to see Candace & Kyemyung! C u in 2027 if not earlier.

#systemsimmunology #AI #machinelearning #humanimmunology #immunevariation #immunesetpoint #immunehealth #humanimmunomeproject

As technology advances, we envision charting personal immune setpoints and immune health metrics as well as harnessing immune variation to detect disease earlier and optimize responses to interventions. We look forward to discussions and collaborations in this exciting area of research.

Given the immune system’s involvement in many if not all diseases and the capacity of immune cells to surveil tissues, immune setpoint and immune health measures offer informative windows into health and disease.

🧵 AI and Machine Learning in Immunology
🎾 An overview of the history of AI and Machine Learning and key approaches
🎾 The use of AI to compress complex multimodal immunological data into meaningful representations that capture essential relationships across biological scales

🧵 Immune Setpoint and Immune Health
🎾 The concept of "immune setpoints" - personal immune states that determine and predict functional outputs; how personal immune setpoints are established and determined
🎾 The concept of “immune health” and approaches for quantifying and measuring it

🧵 Human Immune Variation
🎾 Drivers of human immune variation and their links to health outcomes
🎾 Probing human immune system states and variations through perturbation approaches (like vaccination) combined with longitudinal multimodal immune profiling and computational modeling