John Tsang

excited to announce that this January we are relocating to Yale to start a theory initiative at the Center for Systems and Engineering Immunology (CSEI): @yalecsei.bsky.social

looking to hire 2 postdocs to join us in this endeavor.

more details can be found here: sites.google.com/uw.edu/statp...

🎉 Big news! We’ve just released the first draft of #CancerImmuno's conference programme!
Check out the website to explore what the chairs have been busy organising!
Don't forget to register and submit your abstract.
Click here to view the programme: bit.ly/4pZwmKQ

AI immunologists are here: Are they ready for prime time? AI-based tools can help immunologists with a range of tasks but have limitations.

An accompanying Focus by John Tsang (@tsanglab.bsky.social) provides a broader perspective of #AI & #immunology.
www.science.org/doi/10.1126/...

AI and immunology AI is rapidly becoming part of many aspects of daily life, with an impact that reaches all fields of research. We asked investigators to share their thoughts on how AI is changing immunology research,...

Hear from investigators including HIP Co-CSO @tsanglab.bsky.social on how AI is changing immunology research, what is necessary to move forward, the potential and the pitfalls, and what will remain unchanged as the field journeys into a new era.

www.cell.com/immunity/ful...

How mapping the entire immune system could revolutionize medicine : Short Wave David Ewing Duncan has spent the last 25 years being poked and prodded in the name of science. He’s signed up for hundreds of tests because, as a journalist, he writes about emerging health breakthrou...

Fascinating new podcast on the immune system as the body's early warning system 🧬

@tsanglab.bsky.social (HIP co-CSO) & David Ewing Duncan explain how a blood test could predict disease before you have symptoms

The future of catching things early looks really promising!

www.npr.org/2025/11/12/n...

#CancerImmuno speaker list is live!📢
Join us in sunny Lisbon, July 2026. Register now and submit your talk to share your research.
Early Bird Deadline: 15 Jan 2026
👉 Click here to register: bit.ly/4qZVqmd
#FusionImmunology #FusionCancerResearch

Notes on a compelling discussion with @tsanglab.bsky.social

Genome = blueprint.
Immunome = real-time sensor.
The "curse of dimensionality" (millions of data points per sample!) meets AI compression.

Result? We can finally map the human immune system at scale.

@humanimmunomeproject 🚀

Just saw a post which misspelled 'Machine learning' as 'Machine earning', and I wondered if that was a Freudian slip.

woohoo! well done Toronto - brings back childhood memories of the back-to-back world series won by the Jays...

Big news: We've announced the largest #systemsimmunology collaboration in history! Ten world-class research institutes are joining @immunome.bsky.social in a pioneering plan to understand human immune response variability.

www.humanimmunomeproject.org/news/human-i...

@tsanglab.bsky.social

Picture of some of our amazing workshop presenters.

Thank you #CZBiohubNY Mini Workshop presenters and attendees! Great talks by @czbiohub.bsky.social and @yaleschoolofmed.bsky.social scientists. Grateful to #CZI and @tsanglab.bsky.social for bringing us together. Thank you Susan Rosenthal, Elizabeth Ferris and Lital Manor for superb event logistics.

Exciting lineup at today's #CZBiohubNY Mini Workshop hosted by @yalemedicine.bsky.social, @tsanglab.bsky.social and @yalecsei.bsky.social. Thrilled to welcome @czbiohub.bsky.social and @chanzuckerberg.bsky.social investigators and team members to Yale for this day of science and interaction.

What an amazing work @iannaconelab.bsky.social &friends just out @natimmunol.nature.com, it was really cool to have a preview of this fantastic work at the 2025 ENII EFIS EJI Summer School! Many congrats Matteo &co! Check it out here 👉 www.nature.com/articles/s41... & here 😉 👇👇👇

So important! Please contact your Republican senators, especially Sen. Susan Collins (R-ME), Sen. Shelley Moore Capito (R-WV), Sen. Bill Cassidy (R-LA), Sen. Katie Britt (R-AL), and Sen. Dave McCormick (R-PA). 🙏 amplify!

Congrats, Tomer!

Added a bunch of new folks. Let me know if anyone wants to be added.

A systems immunology analysis of Alzheimer’s disease reveals an age- and environmental exposure-independent disturbance in B cell maturation Alzheimer’s disease is a severe neurodegenerative disorder, with multifactorial mechanisms of disease development and progression. Evidence from genetic association studies, animal models, and clinica...

Pre-print time! Our new study on #systemsimmunology analysis of #Alzheimers patients is out now on @medrxivpreprint.bsky.social.

This is the culmination of a long collaboration with Rik Vandenberghe, Stephanie Humblet-Baron and Lidia Yshii's labs at KU Leuven. 🧵1/8

www.medrxiv.org/content/10.1...

Atul Butte’s talk introduced me to systems biology—I was presynapse scientist and opened my horizon to "biomedical moments, thawing frozen discoveries in data". Ideas that changed my career. Thank you for the science, the spirit, and the inspiration. You will be remembered.

Atul has been a constant inspiring force. He is perpetually optimistic and never stops to empower the world with more data and motivate all of us to dig deeper and be more innovative with data. I miss his energy and our conversations. RIP - May memories of Atul continue to inspire us all.

A Review of the President’s Fiscal Year 2026 Budget Request for the National Institutes of Health | United States Senate Committee on Appropriations United States Senate Committee on Appropriations

Senate hearing on the FY26 NIH budget with Jay Bhattacharya
June 10, 10am ET
www.appropriations.senate.gov/hearings/a-r...

FlyBase funding squashed amid Harvard grant terminations The team behind the Drosophila genetics database is now requesting donations from labs to keep the resource afloat.

FlyBase, a crucial resource for drosophila research, has lost its funding because its grant is awarded to Harvard. The team is scrambling to find other sources of funds, including donations from labs. Read more: www.thetransmitter.org/community/fl... @flybase.bsky.social

My colleague and friend @scripps.edu, @ardemp.bskyverified.social, on the NYT front page today

I appreciate the offers from other scientists to help Harvard (students, labs, etc) through this attack, but what would be most helpful is for you to use your position to contact your elected representatives and make it clear this fight isn't just Harvard, it will affect you, and their districts too

YouTube video by Amanpour and Company Breakthrough Prize-Winning Biochemist on the Deadly Cost of Funding Cuts | Amanpour and Company

David Liu @harvard.edu beautifully articulates the criticality of basic science funding for developing revolutionary therapeutics like life-saving base editors 👏

youtu.be/8YhJM6zxYDw?...

All of NIH funding to Northwestern University is frozen. This pause includes noncompeting approved funding, new and competing grants with fundable scores. No reimbursements for money already spent have been received since March. This situation is rarely reported so please Please get the word out!

7/10 In a combined analysis of infants and previously sequenced adults (generated by @tsanglab.bsky.social lab; PMID:33713619), infants display a similar ISG signature in monocytes but a markedly enhanced ISG signature in T and B cells, which is consistent with infant specific immune features.

Exciting study on infant immune responses to sars-cov-2 and how they compare to adults.

1/10 I am very excited to share our latest study, now out in @natcomms.nature.com. We applied a multidimensional approach to decipher the immune responses to SARS-CoV-2 infection in 2-month-old hospitalized infants. We analyzed: scRNA-of PBMCs, serum cytokines and antibody responses. rdcu.be/emkNa

So let me get this straight: masks are bad and un-American if worn to fight a pandemic, but good if worn by people claiming to be government agents when they kidnap people off the street

Wonderful to catch up with friends and colleagues at #aai2025. Ofer Levy, Mercy Prabhudas, Donna Farber, me, and Bali Pulendran. Adding @lucasite-lab.bsky.social in the second one!