Ramon Duran-Romaña

Energetic profiling reveals thermodynamic principles underlying amyloid fibril maturation - Nature Communications Energetic profiling of cryo-EM time series for IAPP, tau, and α-synuclein reveals how amyloid fibril maturation is driven by sequence-encoded hotspots. Rearrangement of APRs anchors growth, while cofa...

🚨Thrilled our work is out in @NatureComm!🚨

Energetic profiling of >110 cryo-EM amyloid fibrils (IAPP, tau, α-syn) reveals how APRs + cofactors shape fibril maturation and disease-relevant polymorphs.

Read the full paper: doi.org/10.1038/s414...

Proteome-wide determinants of co-translational chaperone binding in bacteria - Nature Communications This study integrates ribosome profiling, single molecule methods and computational predictions to reveal that molecular chaperones bind ‘unsatisfied’ residues exposed on partial nascent folds, ration...

Cool new paper by Galmozzi et al.!

www.nature.com/articles/s41...

They show that bacterial chaperones bind regions of nascent proteins with exposed "unsatisfied residues" (segments missing key native contacts due to ongoing translation).

A shared theme with our recent work on Native Fold Delay.

Energetic profiling reveals thermodynamic principles underlying amyloid fibril maturation Amyloid fibrils adopt diverse structural polymorphs that underlie disease-specific phenotypes, but the thermodynamic principles guiding their formation and maturation remain poorly understood. Here, w...

🚨New lab preprint!🚨
Thermodynamic profiling of cryoEM fibrils shows that key stabilizing motifs shuffle during amyloid maturation, while cofactors ease structural frustration to let energetically optimal polymorphs emerge.
www.biorxiv.org/content/10.1...

A new @MolecularCell paper shows that bacterial sRNAs can bind within coding sequences and enhance protein activity without affecting mRNA levels, pointing towards a new mechanism of co-translational folding regulation!
Could this be used as tool to induce translation pausing? 👀
#translation

Had a fantastic week at @embl.org to learn the ins and outs of ribosome profiling directly from some of the best in the field! Grateful to the amazing organisers, trainers, and fellow participants for such an enriching experience.
#ProteinTranslation #EMBORiboProf

Very excited to share our new preprint together with @daniedaaboul.bsky.social, where we studied the gene regulatory code that hippocampal granule cells (GCs) use during synapse formation (1/n)

Native Fold Delay and its implications for co-translational chaperone binding and protein aggregation - Nature Communications During vectorial protein translation, native interactions are temporarily unsatisfied. Here, authors introduce “Native Fold Delay”, integrating protein topology with translation kinetics to quantify t...

Most proteins fold co-translationally, but what if key residues aren’t available in time? Our new study introduces Native Fold Delay, a metric that links protein topology and translation rates to quantify folding delays. ⏳
Read more here www.nature.com/articles/s41...