Miguel Mesquita

Homeostatic control of energy metabolism by monocyte-derived macrophages
@elmiguelche.bsky.social and colleagues show that macrophages sense dysregulated iron metabolism in parenchymal cells and respond by sustaining mitochondrial function in affected cells
www.embopress.org/doi/full/10....

Homeostatic control of energy metabolism by monocyte-derived macrophages | The EMBO Journal imageimageMacrophages play critical roles in the homeostatic control systems that maintain vital parameters within physiological ranges. This study characterizes how mouse monocyte-derived macrophages...

🧵 Thrilled to share our new work in @embojournal! Over a century after Metchnikoff recognized macrophages as central to organismal homeostasis, we reveal how they act as metabolic guardians through an unexpected mechanism.
www.embopress.org/doi/full/10....
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The fast-evolving FIKK kinase family of Plasmodium falciparum can be inhibited by a single compound - Nature Microbiology FIKK effector kinases underwent rapid evolutionary expansion and are a druggable target in Plasmodium falciparum.

Better late than never, but I am thrilled to share our newest research from the Treeck lab!!! www.nature.com/articles/s41...

Rewring lipid metabolism to sustain thermoregulation during sepsis. Don’t let it get cold! A very interesting piece from Miguel Soares lab @elmiguelche.bsky.social @gimmfoundation.bsky.social

Rethinking jaundice A buildup of unconjugated bilirubin may be a protective response to malaria

Rethinking jaundice | Science www.science.org/doi/10.1126/...
Excellent work to start the week in full force! Miguel Soares lab uncovers a protective role for bilirubin, a product of heme catabolism, during malaria infection. A must read!

A metabolite-based resistance mechanism against malaria Jaundice is a common presentation of Plasmodium falciparum malaria, which arises from the accumulation of circulating bilirubin. It is not understood whether it represents an adaptive or maladaptive r...

A metabolite-based resistance mechanism against malaria | Science www.science.org/doi/10.1126/...

@gimmfoundation.bsky.social

📼 A coluna de Salgueiro Maia dirige-se para o Quartel da GNR no Largo do Carmo. https://j.mp/QuartelGNR #25a74

25 de Abril sempre! Malária nunca mais! <p>Tal como na malária, também não existe uma vacina contra o fascismo. Apenas a educação, a liberdade, a justiça e a empatia nos podem proteger</p>

For portuguese readers. Tomorrow is Portugal’s liberty day and it was never so fragile.
A necessary awakening call for what’s happening indoors and outdoors, comparing malaria infection with other parasites.

expresso.pt/opiniao/2025...

Bilirubin metabolism in the liver orchestrates antiviral innate immunity in the body @cp-cellreports.bsky.social
www.cell.com/cell-reports...

Evolution of resistance and disease tolerance mechanisms to oral bacterial infection in Drosophila melanogaster | Open Biology Pathogens exert strong selection on hosts that evolve and deploy different defensive strategies, namely minimizing pathogen exposure (avoidance), directly promoting pathogen elimination (resistance) a...

Time to give an update on the fantastic work by @taniafpaulo.bsky.social during her PhD, now published in @royalsocietypublishing.org on the evolution of resistance and disease tolerance mechanisms to oral infection in #Drosophila
royalsocietypublishing.org/doi/10.1098/...
#infection #immunity 🤓🎊

What childhood was like before vaccines The anti-vax movement has gone mainstream, but before these shots, grief and loss marked the lives of children.

What childhood was like before vaccines www.vox.com/health/40268...