ARPA-H

CIRCLE: Critical Illness Immunological Reprogramming and Control Point Learning Engine

Creating more “Happy Birthday”s & “Happy Anniversary”s. By monitoring the immune system during critical care, our CIRCLE program will empower doctors to fine-tune treatments, halt disease progression & save lives.

Register for Proposers' Day in Arlington, VA on 3/11. www.arpa-h.gov/explore-fund...

There's a reason Boston is a global hub for health innovation. Thank you for having us for a second jam-packed day — the energy here is unmatched and we're just getting started.

ARPA-H GLIDE program set to prevent and cure human disease by targeting the lymphatic system The Advanced Research Projects Agency for Health (ARPA-H) supports transformative research to drive biomedical and health breakthroughs ranging from molecular to societal to provide transformative hea...

That ends now. Our GLIDE program will build the first therapeutic toolkit to repair, restore & regenerate damaged lymphatic vessels—launching a new field of lymphatic medicine. Meet the awardees (2/2) arpa-h.gov/news-and-eve...

For decades, medicine managed chronic disease symptoms — while ignoring the system connecting them all. When it breaks down, the damage radiates everywhere — heart failure, diabetes, autoimmune disease, obesity. And there are zero FDA-approved treatments that actually repair it. (1/2)

The future of human health is being built right now. And we're investing in the people bold enough to create it. (2/2)

We’re LIVE in Boston and surrounded by innovators who refuse to accept the status quo in health. Boston is where biotech's brightest minds push boundaries and save lives. That's exactly why we're doubling down here ensuring every dollar drives game changing breakthroughs. (1/2)

What if the ultimate health monitor was invisible?

OCULAB teams are building sensors that live in your tear duct, read your body's chemistry in real time, and deliver treatment when you need it — not on a fixed schedule. arpa-h.gov/news-and-eve...

Day 1: Boston doesn't just talk about the future — it builds it. Grateful to be in a city that matches our urgency.

PCX ~ Creating Change for Pediatric Care in Rare Disease - YouTube 50% of childhood cancers are rare. ARPA-H's Pediatric Care eXpansion (PCX) is building a network so every kid can access care—no matter their zip code. These...

50% of childhood cancers are rare. Pediatric Care eXpansion is building a network so every kid can access care—no matter their zip code.

These are the voices moving us — and our partners — forward. #RareDiseaseDay www.youtube.com/playlist?lis...

Your proteins are making deadly typos. BIOGAMI is teaching them to spell correctly. When proteins in the body misfold, they can trigger diseases like ALS, Parkinson's and Alzheimer's – but what if we intervene before that happens?

Watch Proposers' Day highlights ⬇️ arpa-h.gov/explore-fund...

Last week's PCX Roadshow proved something powerful: when you put the right mission in front of the right people, momentum builds fast.

200+ pediatric hospitals & care centers. One network.

This is what happens when dedication meets urgency. Learn more: arpa-h.gov/news-and-eve...

Most of us don’t just want longer lives, but more years of good health. PROSPR awardees are spotting early signs that health is slipping, building systems for aging clinical trials & testing new drugs that could be the 1st gen drugs to extend healthy years. Meet the teams: arpa-h.gov/news-and-eve...

ARPA-H announces $50M to expand pediatric care across the country The Advanced Research Projects Agency for Health (ARPA-H) supports transformative research to drive biomedical and health breakthroughs ranging from molecular to societal to provide transformative hea...

PCX connects children's hospitals so they can easily share important health information. No more incomplete records slowing down treatment. No more delayed diagnoses. Just faster, smarter, more connected care. (2/2) arpa-h.gov/news-and-eve...

200+ hospitals. One mission: ending pediatric brain cancer. Our Pediatric Care eXpansion (PCX) effort launched with $50M to ensure every child and their families have access to the best possible care, regardless of where they live. (1/2)

Critical illness moves fast. We need to track its every move. CIRCLE is making that possible — using AI + digital twin technology to control the body’s immune response in real time, so clinicians can personalize care when every second counts. Learn more: arpa-h.gov/news-and-eve...

ARPA-H opens first interventional clinical trials to outpace cancer in real time The Advanced Research Projects Agency for Health (ARPA-H) supports transformative research to drive biomedical and health breakthroughs ranging from molecular to societal to provide transformative hea...

testing, anticipating resistance, and adjusting.

Enrollment now open for patients with metastatic breast or lung cancer. (2/2) arpa-h.gov/news-and-eve...

Cancer changes. Your treatment should too. Too many of our loved ones have been treated with a plan made on Day 1, even when their tumor evolves, resists, and outsmarts that plan by month three.

ADAPT trials will track tumors in real-time — (1/2)

... bring the future of health straight to rural communities. We’re not studying the problem – we're solving it.
▫️Mobile hospitals bringing care directly to you
▫️Robot-assisted surgery in more places
▫️Protecting small-town health systems from hackers
▫️AI tools helping doctors treat heart disease
2/2

World-class care, no matter where you live. Every town, every county, every zip code.

This week, ARPA-H collaborated with HHS Deputy Secretary Jim O’Neill and CMS Administrator Dr. Mehmet Oz to do something big... (1/2)

🚨 BIOGAMI Proposers' Day Registration is closing soon – sign up by Feb. 18 at 5pm ET for in-person attendance, or by Feb. 19 at noon ET for virtual attendance. arpa-h.gov/explore-fund...

The Race to Measure How We Age As biological age tests proliferate, experts are excited about their potential—but warn of their limits.

PROSPR (Proactive Solutions for Prolonging Resilience) is tackling humanity's most ambitious challenge: stopping age-related diseases before they start, extending years of vitality.

ARPA-H Program Manager Dr. Andrew Brack spoke to TIME about "The Age of Longevity" ⬇️ time.com/collections/...

ARPA-H 101: Assembling a research team The Advanced Research Projects Agency for Health (ARPA-H) supports transformative research to drive biomedical and health breakthroughs ranging from molecular to societal to provide transformative hea...

Big healthcare breakthroughs rarely happen in silos. Our programs are built for multidisciplinary teams — bringing together builders across the biomedical ecosystem to turn ambitious ideas into real-world solutions.

Learn how to assemble the ultimate team 👇 arpa-h.gov/news-and-eve...

ARPA-H Project Awardees The Advanced Research Projects Agency for Health (ARPA-H) supports transformative research to drive biomedical and health breakthroughs ranging from molecular to societal to provide transformative hea...

... to see how teams are cultivating U.S. wheat varieties and harnessing wheat germ extract to manufacture next-generation APIs.

Learn more about WHEAT, Tritica Biosciences, and other project awardees. (3/3) arpa-h.gov/explore-fund...

This project could improve how we make:
▫️Epinephrine (severe allergic reactions)
▫️Insulin (diabetes)
▫️Antibodies (immune and cancer therapies)

Our Scalable Solutions Office Portfolio Lead James Coburn recently visited Tritica Biosciences in Kansas ... (2/3)

Clinical need is constant. Supply chains aren’t. We can’t keep relying on slow and outdated paths to produce the active ingredients our medicines depend on.

WHEAT is building a simpler, scalable way to produce APIs — using American-grown wheat and wheat germ extract. (1/3)

Freezers shouldn’t decide who gets life-changing therapies.

BoSS is pushing past cold-chain limits to develop room-temperature stable biologics — unlocking access for patients in every community.

Catch the Proposers’ Day highlights! arpa-h.gov/explore-fund...

Unfolding Innovation: our new BIOGAMI program strives to eliminate diseases like ALS and Parkinson's by exposing the earliest stages of protein misfolding and clumping—stopping lasting damage before it starts.

Register for hybrid Proposers' Day on Feb. 20 in Arlington, VA arpa-h.gov/news-and-eve...

What if we could detect & repair the earliest stages of protein dysfunction in the body to eliminate diseases like ALS & Parkinson's?

Our BIOGAMI program will crack the code on disordered proteins—and then harness that knowledge to force misfolded proteins back into line. arpa-h.gov/news-and-eve...

“ARPA-H convened its Proposer's Day for the ADVOCATE Program—and if you're working in AI, digital health, or cardiovascular care, you should be paying attention.” - Randi S.

Proposers' Day was UNREAL and it's only the beginning. (5/5)

“This is a FANTASTIC program coming from the federal government.” - Matt P.

“It was a privilege to present to the ADVOCATE program.” - Bilal N. (4/5)