Alex Swarbrick

Felling inspired after my visit to The Broad Institute. Brilliant science in a collaborative energised environment. Thanks @azizalkhafaji.bsky.social and Gammy Al-Eryani for hosting

I’m looking for a PhD student to work on an exciting new collaboration with @azizalkhafaji.bsky.social at the @broadinstitute.org. Together we are using single cell long-read sequencing to understand tumour evolution and microenvironments. Hybrid computational and molecular role. 🧬

Thankyou for hosting us! We are so impressed by the quality of the science, collaboration and facilities at @pmresearch-uhn.bsky.social. Looking forward to developing exciting new projects together

TiME for a change: The tumor microenvironment as the missing piece in cancer therapeutics Current anti-cancer treatments often neglect the role of the tumor microenvironment (TME) in resistance and progression. In this Perspective, the authors argue that better preclinical models, understa...

In this #Perspective @alexswarbrick.bsky.social @jeremymedonc.bsky.social &co argue that better preclinical models and understanding of stromal cells in the tumor microenvironment are needed to improve #cancer therapies 7/9
plos.io/4of0fXe

An exciting new paper on the application of federated deep learning to pan-cancer proteomic data. Congrats to the Procan team for this achievement! Very happy to have contributed our breast cancer dataset to this important work.

doi.org/10.1158/2159...
www.cmrijeansforgenes.org.au/research/res...

Today is the last day in the lab for for Marion Motard, who joined the lab for her Masters then stayed on as a research assistant. She did brilliant work on GNNs to predict gene module enrichment in histology images. She is returning to Europe, quickly offer her a job in ML/computational !

I had a great time at the #wehispatial25 meeting. So much excellent spatial ‘omics going on in Oz.
But weware the @wehi rubber chicken

#aacr2025 Here we go…

I'm chairing session ED52 "Innovative Approaches in TME Biology: From Profiling to Function" at #AACR2025. I'll present data using cellular and functional genomics to identify small molecule mediators of stromal plasticity. Also the amazing Illaria Malanchi and Nick Navin. LMK if u will be there!

SCVI — Integrating or not? In modern single cell analysis workflows you fit a model to your data that allow you to ask questions about the data.

SCVI — Integrating or not? - www.nxn.se/p/scvi-integ...

The four basic kinds of scientific papers:
1. Noise (no claim and no evidence)
2. Resource (no claim but lots of data)
3. Conjecture (makes a claim, but no evidence)
4. Scientific advance (both makes a claim and presents evidence)

Postdoctoral Fellow - Experimental Therapeutics (Zanivan Lab) at MD Anderson MD Anderson is Hiring! Search available jobs or submit your resume now by visiting this link. Please share with anyone you feel would be a great fit.

If you are interested in joining our growing Lab of CAFs enthusiasts @mdanderson.bsky.social and to understand how CAF metabolism can be harnessed to modulate the immune-TME, we are looking for talented postdocs! 👇🏻
jobs.mdanderson.org/search/jobde...

Thanks Sandra ☺️

Research Assistant - Bioinformatics The Garvan Institute of Medical Research brings together world leading researchers and clinicians, collaborating locally and globally, to improve human health. Our mission is to harness all the inform...

Wanted- *Bioinformatics Research Assistant*. Projects include generation of an international, large-scale, multi-omic breast cancer atlas and understanding response to immunotherapy in breast cancer, prostate cancer and melanoma. Great training opportunities 🧬💻
More info ⤵️
tinyurl.com/33wxkswz

Jobortunities: Shortly advertising for 2 positions, both working on the Breast Cancer Atlas, in Sydney.
- Wet lab research assistant: mol bio +/- pathology desirable
- Comp. Research Assistant: scRNA-Seq, spatial transcriptomics and ML
Details to follow, DM or email if you are a great fit.

🤩

AACR to honor trailblazing breast cancer researchers during the 2024 SABCS® - SABCS Meeting News Christina Curtis, PhD, MSc, left, and Steffi Oesterreich, PhD, will be recognized by the American Association for Cancer Research (AACR) for significant contributions to breast cancer research.

Im thrilled for this recogntion of Christina Curtis and Steffi Oesterreich by the @theaacr.bsky.social at @sabcs.bsky.social. I'm in awe of their achievements and impacts on breast cancer research. They are also two of the nicest people you'll ever meet !
sabcs.cmail19.com/t/d-l-smtjdd...

One of the alluring and theoretical strategies for extending healthspan and longevity is to rejuvenate the thymus gland, promote an intact immune system. Now there's a way to do that in aged mice.

www.science.org/doi/10.1126/...

Thanks to @aruthak.bsky.social and colleagues for the invitation to this fantastic, unique meeting #multi-omics2024.
Thnx for the shoutout to the awesome @martinalexsmith.bsky.social

When you get to be your own caricature!! Grateful to be in #oz sharing science with #friends. For those missing out #multiomics2024 is where #singlecell #spatial #omics #immunology #oncology and #precisionmedicine is where it’s at🥳

Yesterday, I presented our latest results mining single molecule m6A data at #multiomics2024:
We see changes in m6A levels following CRISPR-cas13 knock-down of oncogenic lncRNAs that are independent of mRNA expression levels, revealing new dimensions of highly pertinent biological information

A nice explanation of the space our Cancer Ecosystems Program researchers work in - its tricky! but they are applying spatial and single cell multiomics to clinical samples and taking big steps forward towards better outcomes for patients - check out our team at www.garvan.org.au/research/str...

Public Service Announcement: Check colorblind-compatibility in Illustrator! Under 'View', 'Proof Setup' you can selected a colorblindness type to view your image in that spectra. Click 'Proof Colors' after to remove filter. We chose pink/green, yellow/blue here for accessibility (PMID 38112643).

Both #Cancer #Research starter packs are now completely full!

~300 researchers, oncologists, students, postdocs, patient advocates, and organizations supporting cancer research 🧪🔬⚕️

I hope you'll find these useful to build our community here

Pack 1: go.bsky.app/FEoaJMc
Pack 2: go.bsky.app/6EcjWNA

Truly brilliant work. Calling it a foundation model is a stretch (a mistake many people in the field make). But, the only single-cell AI model in its class that I think is worth the GPU energy expended and one that I excited to utilize. My stamp of approval. www.nature.com/articles/s41...

People deserve a world in which they can live in peace as themselves. What steps are people taking to ensure that in their communities, particularly as the world is going dark?

VAXXED: Game on, with BASE and WEHI Podcast Episode · Phase III · 19/11/2024 · 26m

We are ramping up our attempts to get DC1 immunotherapy into the clinic for colorectal and lung cancer. Here me talk about why DC1s are the right choice, and how
WEHI and PeterMacCC will get it to clinical trial within 2 yrs. Start ~13 min in. podcasts.apple.com/au/podcast/v...

Today I had the opportunity to present our ongoing translation of pan-LOX inhibitors in pancreatic cancer at the Australasian Gastrointestinal Trials Group (AGITG) Annual Scientific Meeting.
Read more about this work here| → www.nature.com/articles/s43... ← |

This is incredible, thanks @deniswirtz.bsky.social

Too often we spend only two weeks choosing a problem and then many years trying solving it, but this limits our potential impact.
A must read for PhD students: Problem choice and decision trees in science and engineering.
pubmed.ncbi.nlm.nih.gov/38608651/