Francisca Vazquez PhD

🧬 Excited to announce the 2nd Euro Cancer DepMap Symposium bringing together leading minds in functional genomics, cancer vulnerabilities, AI, CRISPR and anti-cancer target discovery.📍Join us in Milan for cutting-edge science, open discussion & collaboration. #EuroDepMap #CancerResearch #CRISPR

For those of you interested in cancer synthetic lethality, this should be a v interesting Gordon Conference organised by @mgarnett.bsky.social @vazquezf.bsky.social & Benjamin Schwartz- highly recommended ! www.grc.org/synthetic-le...

New Gordon Research Conference Alert: Synthetic Lethality Approaches in Oncology. www.grc.org/synthetic-le....

Join us 20-25th July 2025 for an intimate meeting with thought leaders in the field. Great for networking and opportunities for early career scientists to present their research.

UCD @ucddublin.bsky.social are recruiting fifty early-career faculty through the Ad Astra Fellowship programme. In the School of Medicine there are two positions related to AI in Medicine that might be of particular interest. Deadline 21st February. Full details here: www.ucd.ie/adastrafello...

SKI complex loss renders 9p21.3-deleted or MSI-H cancers dependent on PELO - Nature Analysis of large-scale CRISPR screening data, combined with experiments in patient-derived tumour organoid models, identifies PELO as a potential therapeutic target in chromosomal 9p21.3-deleted canc...

Exciting new synthetic lethal target emerging from #depmap data 🧪🧬

Frequent passenger mutations in genes involved in mRNA quality control lead to a dependency on PELO-HBS1L

Congratulations to the DepMap team! @vazquezf.bsky.social
#depmap #cancertarget #syntheticlethal

(3/3) This is a great example of how DepMap enables discoveries beyond sequencing, revealing novel therapeutic targets like PELO

This was a wonderful close collaboration with Ed Chan’s team. Huge thanks to Patricia Borck, Isabella Boyle & our amazing team!

(2/2)

MSI-H → TTC37 mutations disrupt SKI function
9p21.3 deletion → FOCAD loss destabilizes the SKI complex

SKIc disruption -> PELO dependency

Both MSI-H and 9p21.3 deletion are frequent in many adult tumors making PELO a potential target for a large patient population

SKI complex loss renders 9p21.3-deleted or MSI-H cancers dependent on PELO - Nature Analysis of large-scale CRISPR screening data, combined with experiments in patient-derived tumour organoid models, identifies PELO as a potential therapeutic target in chromosomal 9p21.3-deleted canc...

(1/3) Excited to share our latest work using
@depmap.org to uncover a new synthetic lethality in two distinct patient populations!

We found that SKI complex inactivation through two independent genomic alterations creates a dependency on PELO

#CancerResearch #SyntheticLethality #Genomics #DepMap

Think zebras: challenges and opportunities for treating rare cancers The adage goes, ‘When you hear hoofbeats, think of horses, not zebras’. However, placing less emphasis on ‘zebras’ – both in the clinical and research space – can prevent many rare cancers from being ...

It's time to tackle rare cancers together - both a scientific opportunity and a moral imperative! I've shared a few brief thoughts in the Trends in Cancer opinions perspective on this topic - out now online www.cell.com/trends/cance...

📣Registration is now open for an exciting Gordon Conference on synthetic lethality organized by Ben Schwartz (GSK), Mathew Garnett (Sanger), and Francisca Vazquez (DepMap Director, Broad Institute)

Highly recommended!

Register here
grc.org/synthetic-le...

Flier for the ICSB2025 conference in Dublin 5-9 October 2025

We will be hosting the International Conference on Systems Biology (ICSB) in Dublin this year – 5-9th October icsb2025.com/registration/ #ICSB2025

DepMap keeps growing—and so does the portal!

To help navigate the portal, new in 24Q4 we’ve launched a new resource page 🚀! Check it out and share your feedback.

We’re kicking off the first DepMap post with a bang!
⭐ 35 CRISPR screens
⭐ NEW data from our Pediatric Dependencies Accelerator Program (learn more at PedDep.org)
⭐ First 281 WES -> WGS
⭐ New Resources page
📣 DepMap is now on dbGaP (phs003444.v1.p1)
Read our release notes for more info!