Daniela Robles-Espinoza

Alessandro and I discussed a paper analyzing a deleterious genetic interaction that causes melanoma in swordtail fishes.

Image shows the first two printed pages of the paper “A forkhead-domain gene is mutated in a severe speech and language disorder” by Cecilia Lai and colleagues, published in Nature in 2001 (volume 413, pages 519-523). The abstract reads as follows: Individuals affected with developmental disorders of speech and language have substantial difficulty acquiring expressive and/or receptive language in the absence of any profound sensory or neurological impairment and despite adequate intelligence and opportunity. Although studies of twins consistently indicate that a significant genetic component is involved, most families segregating speech and language deficits show complex patterns of inheritance, and a gene that predisposes individuals to such disorders has not been identified. We have studied a unique three-generation pedigree, KE, in which a severe speech and language disorder is transmitted as an autosomal-dominant monogenic trait. Our previous work mapped the locus responsible, SPCH1, to a 5.6-cM interval of region 7q31 on chromosome 7. We also identified an unrelated individual, CS, in whom speech and language impairment is associated with a chromosomal translocation involving the SPCH1 interval. Here we show that the gene FOXP2, which encodes a putative transcription factor containing a polyglutamine tract and a forkhead DNA-binding domain, is directly disrupted by the translocation breakpoint in CS. In addition, we identify a point mutation in affected members of the KE family that alters an invariant amino-acid residue in the forkhead domain. Our findings suggest that FOXP2 is involved in the developmental process that culminates in speech and language.

Twenty-four years ago today, our paper “A forkhead-domain gene is mutated in a severe speech and language disorder” was published: www.nature.com/articles/350....
A personal thread about the ups & downs of the journey we took to get to that point....1/n
🗣️🧬🧪

Fascinating story!!! Thanks for sharing, enjoyed reading it a lot 😄

Sunbed

Despite regulation, commercial sunbeds remain popular with young people and indoor tanning is experiencing a boom in popularity.

An outright ban of sunbeds is likely to be cost effective for the NHS, says this Analysis
www.bmj.com/content/391/...

This only happens to you once

Come join us next year at the @embo.org meeting "The Many Faces of #Cancer evolution"! Organised by @ciriellolab.bsky.social @magnanilab.bsky.social @turajliclab.bsky.social & Céline Vaillot! In beautiful Rimini 🇮🇹

More information in the poster below ⬇️ and at

meetings.embo.org/event/26-cancer-evo

"Submitting an abstract without all the data collected" and it's the facade of a building without any actual building behind it. A white apartment complex module or something with a freight entrance or garage door and some sliding glass doors, but it's just sky behind it. Stolen from the Internet.

"We present exciting and novel new findings on the topic of the gel I'm about to run, with confirmatory experiments I'll run next Tuesday..."

FlyBase needs your help! We ask that European labs continue to contribute to Cambridge, UK FlyBase, whereas US and other non-European labs can contribute to US FlyBase. For more information and how to donate: wiki.flybase.org/wiki/FlyBase...

I am excited to announce that the position of a senior postdoc (3 +3 years) in the field of theoretical biology is available in my group.

The position provides the opportunity to closely interact with experimentalists and develop own research projects.

Please RT.

Details 👇:
shorturl.at/iiiOv

Muchas felicidades Fernando y equipo! Increíble trabajo 😀😀😀

The MUC19 gene: An evolutionary history of recurrent introgression and natural selection We study the gene MUC19, for which some modern humans carry a Denisovan-like haplotype. MUC19 is a mucin, a glycoprotein that forms gels with various biological functions. We find diagnostic variants ...

Our paper on the evolution of MUC19 in humans, Neanderthals, and Denisovans is finally out today in Science!

This has been a six-year effort by 13 authors to weave together 3 separate but related evolutionary stories around this one gene (more on thread 🧵).

www.science.org/doi/10.1126/...

YouTube video by CERI & KRISP Centre Epidemic Response & Innovation Which Skills Help Scientists Succeed Beyond the Lab? Writing skills! #RealTalkResearch 3 :

Here my advice for young scientists: while technical and lab expertise are vital, core skills such as writing for non-specialists can open new doors - from securing grants to creating broader impact for scientific publications. See #RealTalkResearch series - youtu.be/Tu4bl3PJPHQ?...

YouTube video by Biomod Biotecnología sin Fronteras: Nanotecnología Mexicana

Please consider supporting our students! The only Latin American team 🇲🇽 in BIOMOD, an international #science competition. They worked on an innovative treatment for colon cancer using nanotechnology & DNA origami 🧬🔬

Learn more!
youtu.be/GV0cnb3biJQ?...

Donate:
crowdfunding.tec.mx/s/detallepro...

We are super happy to host Miguel García-Knight @levelab.bsky.social at @liigh-unam.bsky.social today! He's talking about the intriguing work on virus characterisation and surveillance he's doing in Mexico 🇲🇽 at IIB-UNAM

Check out the call for participants for the Global Culicidae project!! ⬇️

Amazing new work from @patriciapossik.bsky.social's group!!! Check it out - An amazing repository and characterisation including PDXs, sequencing, cell lines - with new biological insights! #acralmelanoma

New semester, new bluesky account!
We start this new semester at UNAM welcoming new and current students of the Genomic Sciences Undergraduate Program at UNAM in Juriquilla!

This is really cool! Congratulations! Also @delvecchyo.bsky.social you will enjoy this!!

🤣🤣🤣

"Access to a PhD-level expert in your pocket"

I'd like to have a word with ChatGPT's PhD advisor please

I'd like them to tell me about their discovery of the cyτlasma and the centrosome/lysosmoe duality

It drew the state boundaries fairly accurately I think but then completely mislabeled the states and created new ones 😅

This explains why Tlaxcala finally conquered central Mexico after their attempts at telling people that they DO exist! (This image is from an actual government campaign 😂)

I imagine Querétaro's new name Is Quetzarr? Though we seem to have been conquered by Tlaxcala. The ultimate vengeance for the "state that doesn't exist"

I also enjoy Quezacala, Nora and Ijalislo a lot. Hope to visit some day.

"Access to a PhD-level expert in your pocket"

Prompt: Can you make me a map of Mexico with the names of all states? can you list them after the image as well?

I was born in the great state of Cusidad le Mexico. We're proud of our French origins. Also I see Yucatan finally took over its neighbours

a robot with a smiley face on its face is holding a binary sphere ALT: a robot with a smiley face on its face is holding a binary sphere

You can do it!! Sending best wishes and good vibes - teach those robots how to count 💪🏽

Follow up question why are you awake? Because celebrity?

How do you deal with the trolls Theo

Also- super interesting though couldn't replicate after a few tries :p

a 3d rendering of a colorful dna molecule with a black background ALT: a 3d rendering of a colorful dna molecule with a black background

Happy #RNA Day everyone!!! 🎉🎉🎉

#AUG1st #RNASky

Call for 20 Assistant Professor positions Karolinska Institutet is a world-leading medical university with a long and proud history of ground-breaking research. We are now recruiting outstanding early-career researchers with particularly exce...

Wow

Karolinska Institutet is recruiting 20 outstanding early-career researchers for assistant professor positions

ki.se/en/about-ki/...

Fifteen years later, Science retracts ‘arsenic life’ paper despite study authors’ protests Belated decision on widely disputed 2010 study pleases some critics but puzzles and dismays others

Science finally retracts the Arsenic life paper www.science.org/content/arti...