Leo Kiss

Postdoctoral Scientist - PNAC - Dr Patrycja Kozik - LMB 2780 - Cambridgeshire (GB) job with MRC Laboratory of Molecular Biology (LMB) | 12854641 Postdoctoral Scientist Salary £42,694 per annum  MRC Laboratory of Molecular Biology, Cambridge, UK Applications are invited for a Postdoctoral Sci...

We have a postdoc position available in our lab at the @mrclmb.bsky.social - the project is on exploring targeted protein degradation in dendritic cells to facilitate T cell-mediated immune responses - see the link below for more information. Deadline this Monday!

www.nature.com/naturecareer...

Thanks! Can't wait for it!

The accessory adapters FAF1, FAF2, and UBXN7 accelerate proteasomal degradation by increasing prior p97-mediated substrate unfolding A group of accessory adapters positions the p97 adapter Ufd1 to boost substrate unfolding and subsequent proteasomal degradation.

VCP/p97’s accessory adapters (FAF1, FAF2, UBXN7) boost unfolding and subsequent proteasomal degradation. #ubiquitin. Our paper is out now:
Science Advances www.science.org/doi/10.1126/...

Very exciting work from my colleagues @hemmo-lab.bsky.social to which I could contribute a tiny bit!

Thanks a lot Adam and see you on the next meeting!

Thanks a lot Helen. Looking forward to catching up on the next conference!

Thanks a lot Tim! Indeed they are :-)

Thanks Doris! I am super excited to join the department. See you very soon!

Thanks David! See you soon in Vienna!

Thanks Mike, see you soon in Essen!

Thanks a lot David! Let's hope all the proteins, and especially ubiquitin, will be happy in my lab!

Thanks a lot Will!

Thank you for having me :-)

Are you passionate about interdisciplinary research and eager to contribute to groundbreaking discoveries in the areas of #biochemistry, #structuralbiology, #biophysics, #cellbiology, #chemicalbiology and #syntheticbiology? Apply NOW for a #fullyfunded #PhDpositions @IMPRS-LM.
Deadline: April 6

Ubiquitin & Friends Fiesta in Vienna, 29-30 April 2026.
Great speakers, small size, a friendly community, perfect for early-career researchers to connect with fellow ubiquitin enthusiasts. Sign up at www.protein-degradation.org/symposium/ and submit abstracts for talks and awards.
#ubfriends26

I am very grateful to my mentors Brenda Schulman, Leo James and David Neuhaus and all my fantastic colleagues over the years, without whom this would not have been possible.
(3/3)

You are passionate about ubiquitin, proteostasis and cellular biochemistry and want to be part of a collaborative, ambitious, excited and fun team? I am recruiting PhD students via the @imprs-lm.bsky.social graduate school:
www.imprs-lm.mpg.de/index.php/le...
(2/3)

I am incredibly excited to share that I will start my independent lab at the @unidue-zmb.bsky.social at the @unidue.bsky.social as Junior Professor of Cellular Biochemistry. Research in my lab has the goal to decipher the ubiquitin code!
There are multiple open positions!
(1/3)

Super cool! Congratulations!

Excited to share our new paper uncovering how FANCD2 recognises various DNA repair proteins www.biorxiv.org/content/10.6... @hw1o9.bsky.social

AlphaFold modeling of polyubiquitin complexes and covalently linked proteins

AlphaFold modeling of polyubiquitin complexes and covalently linked proteins
http://dlvr.it/TR90K4

Balázs Fábián @mpibp.bsky/social & colleagues
@cp-cellrepphyssci.bsky.social
#bps2026

Massive work and big congrats to @versteegga.bsky.social and team!

Our paper is out in @natcomms.nature.com! APOBEC3s drive mutagenesis in cancer. We uncover a novel pathway keeping them in check. The key is APOBEC3 binding of cellular RNAs, which simultaneously controls their nuclear localization and shields them from degradation.

Read it here: rdcu.be/e4qaa

Congratulations @rbdamgaard.bsky.social and Team! Super cool!

🧐 What if metabolic defects are not just a consequence of inflammatory disease - but actively contribute to it?

Inflammation and metabolism are deeply intertwined, but the molecular links remain unclear.

Our new paper in Cell Death & Differentiation uncovers one. 🧵👇
nature.com/articles/s41...

Why do pathological protein aggregates persist in cells and how can we overcome this?
In our new preprint, we show that Tau aggregates fail to initiate selective autophagy and that their autophagic degradation can be restored.
#Autophagy #Tau #Proteostasis

Out now 👇 www.biorxiv.org/content/10.6...

Plants use cell-surface and intracellular receptors that collaborate to detect pathogens🦠. We discovered that a key #ubiquitin recognition event recruits both receptor types into an unexpected dual receptor complex that boost the translation of defence proteins and establishes robust #PlantImmunity👇🏾

Very happy to share our recent preprint describing #Golgi protein quality control #PQC in mammalian cells. #proteasome #ubiquitin #ChemBio Fantastic work by @joaodiamantino.bsky.social and team! #proudPI @unidue-zmb.bsky.social @imprs-lm.bsky.social

Single-molecule dynamics of the TRiC chaperonin system in vivo - Nature Single-particle tracking experiments in intact cells reveal dynamic co- and post-translational interactions of the TRiC–PFD chaperonin complex with client proteins during in vivo protein folding.

I’m excited to share my first-author paper, with co-first author @rongqinxiaoxiao.bsky.social, now out in @nature.com. We developed a live-cell single-particle tracking platform to see how TRiC & prefoldin engage proteins during co- and post-translational folding. 1/9 www.nature.com/articles/s41...

I'm thrilled to share our new publication, with co-first author @ Niko Dalheimer, is now out on Nature. Check out how we use live cell single particle tracking to study real time dynamics between TRiC chaperonin system and it substrates in the crowded cellular environment.