Leo Kiss

Super cool! Congratulations!

Excited to share our new paper uncovering how FANCD2 recognises various DNA repair proteins www.biorxiv.org/content/10.6... @hw1o9.bsky.social

AlphaFold modeling of polyubiquitin complexes and covalently linked proteins

AlphaFold modeling of polyubiquitin complexes and covalently linked proteins
http://dlvr.it/TR90K4

Balázs Fábián @mpibp.bsky/social & colleagues
@cp-cellrepphyssci.bsky.social
#bps2026

Massive work and big congrats to @versteegga.bsky.social and team!

Our paper is out in @natcomms.nature.com! APOBEC3s drive mutagenesis in cancer. We uncover a novel pathway keeping them in check. The key is APOBEC3 binding of cellular RNAs, which simultaneously controls their nuclear localization and shields them from degradation.

Read it here: rdcu.be/e4qaa

Congratulations @rbdamgaard.bsky.social and Team! Super cool!

🧐 What if metabolic defects are not just a consequence of inflammatory disease - but actively contribute to it?

Inflammation and metabolism are deeply intertwined, but the molecular links remain unclear.

Our new paper in Cell Death & Differentiation uncovers one. 🧵👇
nature.com/articles/s41...

Why do pathological protein aggregates persist in cells and how can we overcome this?
In our new preprint, we show that Tau aggregates fail to initiate selective autophagy and that their autophagic degradation can be restored.
#Autophagy #Tau #Proteostasis

Out now 👇 www.biorxiv.org/content/10.6...

Plants use cell-surface and intracellular receptors that collaborate to detect pathogens🦠. We discovered that a key #ubiquitin recognition event recruits both receptor types into an unexpected dual receptor complex that boost the translation of defence proteins and establishes robust #PlantImmunity👇🏾

Very happy to share our recent preprint describing #Golgi protein quality control #PQC in mammalian cells. #proteasome #ubiquitin #ChemBio Fantastic work by @joaodiamantino.bsky.social and team! #proudPI @unidue-zmb.bsky.social @imprs-lm.bsky.social

Single-molecule dynamics of the TRiC chaperonin system in vivo - Nature Single-particle tracking experiments in intact cells reveal dynamic co- and post-translational interactions of the TRiC–PFD chaperonin complex with client proteins during in vivo protein folding.

I’m excited to share my first-author paper, with co-first author @rongqinxiaoxiao.bsky.social, now out in @nature.com. We developed a live-cell single-particle tracking platform to see how TRiC & prefoldin engage proteins during co- and post-translational folding. 1/9 www.nature.com/articles/s41...

I'm thrilled to share our new publication, with co-first author @ Niko Dalheimer, is now out on Nature. Check out how we use live cell single particle tracking to study real time dynamics between TRiC chaperonin system and it substrates in the crowded cellular environment.

Selective proteasomal degradation from the Golgi apparatus membrane https://www.biorxiv.org/content/10.64898/2026.02.04.703791v1

Paper alert! 📢 How do cells fight viruses without harming themselves? 🧬 In @natcomms.nature.com, the @versteegga.bsky.social lab uncover a previously unknown safeguard that keeps DNA-mutating antiviral enzymes in check, protecting the genome while preserving antiviral defense ➡️ tinyurl.com/4xbxz9e8

Formation & function of #MembranelessOrganelles! #CryoET structures of #proteasome storage granules inside cells!
Read our paper @cp-cell.bsky.social!

❕Publication: doi.org/10.1016/j.ce...
❕Press Release: www.biochem.mpg.de/en/pressroom

@uoftmedicine.bsky.social
@erc.europa.eu #UPSmeetMet

LLOMe has long been used to study lysosomal damage, yet how it works has remained a mystery.
Using cryo-electron tomography, we show it forms amyloid structures inside lysosomes that mechanically rupture membranes – revealing a new paradigm for lysosomal failure.

🔗 doi.org/10.64898/202...

#CryoET

Mitochondrial hitch-hiking of Mapt mRNA maintains Tau levels in axons Hitch-hiking of transcripts on organelles, including mitochondria, has emerged as a common pathway to transport mRNAs into the axon to enable their local translation. However, the extent of mitochondr...

New preprint from my lab!!!
We took advantage of the MitoTag mouse line to study what mRNAs associate with mitochondria in axons in vivo, and we were in for a surprise! Other than our favorite Pink1, mainly cytoskeletal mRNAs hitch a ride and pave the way for axon growth. shorturl.at/rYe1U

Exciting new work from @alinathielen.bsky.social on the very elegant E3 regulation of Tryptophan metabolism!

We are excited to share our new preprint which is now available to read on biorXiv: doi.org/10.64898/202... 🎉🎉🎉

Very exciting! Congratulations!

Mark your calendars! Can‘t wait until this years Ub Friends Symposium!

What happens when E3 Ubiquitin Ligase and RNA Enthusiasts team up!
Massive congrats to this transatlantic collaboration between @jakobfarnung.bsky.social from Schulman Lab and @elenaslo.bsky.social from @bartellab.bsky.social
Have a read!

We are thrilled to share our latest work uncovering the mechanistic basis of target-directed microRNA degradation (TDMD). This work was driven by @jakobfarnung.bsky.social and @elenaslo.bsky.social in a fantastic collaboration with Brenda Schulman's lab. tinyurl.com/E3TDMD (1/5)

Very cool work! Reminiscent of how target engaged PIWI is selected from a vast pool of PIWI-piRNA complexes. Only target engaged PIWI is recognized by a GTSF1 protein and Maelstrom in the PIWI* complex. www.cell.com/molecular-ce... @juliusbrennecke.bsky.social @julsportell.bsky.social

Here it is! A new chapter in RNA biology and degradation mechanisms. My brother @jakobfarnung.bsky.social and @elenaslo.bsky.social show that an E3 not only induces the degradation of proteins but also of RNA. Congrats!

Look at this super exciting E3, recognizing the specific RNA-bound state of it’s target protein alone!
Massive Congrats @jakobfarnung.bsky.social and collaborators from @bartellab.bsky.social

UBA6 specificity for ubiquitin E2 conjugating enzymes reveals a priority mechanism of BIRC6 Nature Structural & Molecular Biology - Riechmann et al. uncover structural features governing ubiquitin transfer from ubiquitin-activating E1 enzymes UBA1 and UBA6 to specific E2...

Excited to share our work into ubiquitin E1-E2 specificity mechanisms. CryoEM visualising #ubiquitin transfer,biochemistry,evolution @labhofmann.bsky.social & tissue expression analyses @psarkies.bsky.social Big thanks to the team,reviewers & handling editor @dimitristypas.bsky.social rdcu.be/eTRdR

DUCs are C2 domain containing plant-specific deubiquitinases stabilizing endocytic cargo at the plasma membrane Deubiquitinases (DUBs) remove ubiquitin modifications from proteins in a substrate- or linkage-selective manner and regulate numerous cell-biological processes, including endocytosis. By performing ho...

For all #ubiquitin aficionados out there: Our new study, where we used an #alphafold based screen and found a new class of plant-specific DUBs, which cleave K63 chains and interfere with endocytosis at the plasma membrane. www.biorxiv.org/content/10.6...

Chemical proteomics decrypts the kinases that shape the dynamic human phosphoproteome Mass-spectrometry-based phosphoproteomics enables the analysis of thousands of protein phosphorylation events across the human proteome. However, there is a lack of scalable, hypothesis-free, and stat...

Did you ever come across a phosphosite in your proteomics data for which nothing was known? - I bet so!

We have developed a new strategy termed "potency coherence analysis" that leverages the drug potency dimension in decryptM to decode the kinases that shape the human phosphoproteome.

Read more:

Glad to have this finally published: www.sciencedirect.com/science/arti... lots of new data since the #preprint. If you are into selective #autophagy, #evolution, #proteostasis Please have a look!