Ester Hammond

New CRUK Post-doc position in our group. #mutationalorder #multiomics #cancer.
my.corehr.com/pls/uoxrecru...

Indolequinone-Based Hypoxia-Activated Proteolysis Targeting Chimeras Selectively Degrade BRD4 in Hypoxic Cancer Cells Proteolysis targeting chimeras (PROTACs) have helped to establish proximity induction as an exciting strategy in drug discovery, and there are multiple clinical trials focused on this modality. Howeve...

Hypoxia-activated PROTACs (HAP-TACs) are online in @jacs.acspublications.org (pubs.acs.org/doi/10.1021/...)! Collborative work with Ester Hammond (@hammond-lab.bsky.social). Congrats to Marta Serafini, Sophie Twigger, George Delfas, Max Mallerman, Elliot Bailey & Ewen Calder (@ecalder.bsky.social).

Great end to the week! Thank you to @sophietwigger.bsky.social for aiming high and getting us the Gold award. @oncology.ox.ac.uk

University of Oxford - DPhil in Cancer Science Open Day Join the Virtual DPhil in Cancer Science Open Day to hear more about Oxford’s world-leading research training

Join us for our DPhil in Cancer Science Open Day on Tuesday 2nd September at 12:30pm to find out how a DPhil can be the next step in your cancer research career development!

Register via our Eventbrite link before 1st Sept⬇️ @oncology.ox.ac.uk @medsci.ox.ac.uk

www.eventbrite.co.uk/e/university...

Our pre-print on the development of bivalent ligands for the TRIM24 bromodomain & PHD is now online chemrxiv.org/engage/chemr...

Congratulations to the authors: Michael Platt, Ekaterina Kot, Louise Martin, Antoine Wallabrègue, Liwen Song, Alistair Boyd, Lizbé Koekemoer, & @hammond-lab.bsky.social

As the active PROTAC is revealed selectively in hypoxia, POI (BRD4) degradation occurs mainly in hypoxia. This technology has the potential to give PROTACs that degrade selectively in hypoxic tumors.

This is collaborative work with @hammond-lab.bsky.social - congratulations to all of the authors.

Our pre-print on hypoxia-activated PROTACs (HAP-TACs) is now on ChemRvix: chemrxiv.org/engage/chemr...

We used the indolequinone bioreductive group to protect VHL- or CRBN-recruiting BRD4 degraders rendering them inactive. This group is removed selectively in hypoxia, revealing the active PROTAC.

Exciting news!!! We are recruiting a RA to join my lab at
‪@oncology.ox.ac.uk‬ to study epigenetic reprogramming in stem cells and within the TME using colon organoids

www.oncology.ox.ac.uk/team/giulia-...

Deadline 2nd of July (my.corehr.com/pls/uoxrecru...)

Re-post are very welcome!

Postdoctoral Research Associate in the Blackford Group A position as Postdoctoral Research Associate is available at the Department of Cellular and Molecular Medicine, in the group headed by Dr. Andrew Blackford. Th

We’re #hiring, please share! A fully funded #postdoc position is available in my lab to work on DNA damage response mechanisms.

Please get in touch with your CV if you are interested; closing date: 27th June 2025.

More details here: candidate.hr-manager.net/ApplicationI...

We really are fans of cross-disciplinary projects! Delighted to have contributed to some #PlantScience

I highly recommend working with @kleszczynsk.bsky.social If you're looking for a postdoc and interested in hypoxia and epigenetics take a look at nencki.edu.pl/job/the-nenc...

Meet @halaestephan.bsky.social 👩‍🔬🔬🧪

Hala is a postdoctoral researcher here at the oncology department, working on cancer immunology.

To mark #IWD25, Hala shares her STEM journey & her advice on how to thrive as a woman in academia.

@medsci.ox.ac.uk @hammond-lab.bsky.social
#InternationalWomensDay

Great opportunity for anyone looking for a post doc in Oxford - highly recommend!

Great to see this collaborative work with @emilyflashman.bsky.social and @hammond-lab.bsky.social on @biorxivpreprint.bsky.social. Using our previously developed hypoxia probes (pubs.acs.org/doi/full/10....) to image hypoxia in plants.

What is a UNIQ+ Research Internship? | University of Oxford What is UNIQ+?UNIQ+ Research Internships are designed to provide students from under-represented and disadvantaged backgrounds who are ordinarily resident in the UK with the opportunity to experience

Curious about doing a PhD? 🤔

Join Oxford's research community and work with academic staff on projects in a range of subject areas.

UNIQ+ research internships are now open for applications from UK undergraduates from under-represented and disadvantaged backgrounds.

More info ⬇️

The MSc in Medical Physics with Radiobiology at @oncology.ox.ac.uk welcomes students looking to kickstart a career in medical physics research, clinical practice, or industry.

Find out more: tinyurl.com/4a4km74v

ICYMI

We are recruiting a new Associate Professor in cell and molecular biology, with a preference for immunology, inflammation and/or infection - all defined broadly

Come and be our colleague!

Deadline 28 Feb, please spread the word!

www.path.ox.ac.uk/vacancy/asso...

Congratulations to the new Dr Twigger @sophietwigger.bsky.social and many thanks to Angie Russell and Navita Somaiah for examining. Let the celebrations commence

Hypoxia promotes tumor immune evasion by suppressing MHC-I expression and antigen presentation | The EMBO Journal imageimageHypoxia contributes to cancer resistance to both standard therapies and immunotherapy. This work demonstrates that tumor hypoxia promotes immune evasion by autophagy-mediated downregulation ...

Great start to 2025. Tumor hypoxia promotes immune evasion by autophagy-mediated downregulation of MHC class I expression leading to reduced antigen presentation. Great work from @halaestephan.bsky.social www.embopress.org/doi/full/10....

Are you full of ideas, thinking about applying for fellowships and looking for a home i.e. junior group leader position? We're recruiting! my.corehr.com/pls/uoxrecru...

We enjoyed a great holiday celebration, throwing some darts (some better than others) and eating lots. Happy holidays to all @sophietwigger.bsky.social @katroseworth.bsky.social @olivierzanier.bsky.social @brightw.bsky.social @halaestephan.bsky.social @edpetrosyan.bsky.social @chuminz.bsky.social

Exciting opportunity to establish your own research group in the Department of Oncology at Oxford. Please spread the word

my.corehr.com/pls/uoxrecru...

Still a month left to apply for one of our fully funded PhD positions in Birmingham, UK. EU / International students welcomed. DNA replication, biochemistry, structural biology. Supportive, multinational team. Please RT (not just ❤️). Thank you!

Dear all, my first post! I have postdoc positions available if you would like to join my lab in beautiful Sussex by the Sea! Please contact me on k.w.caldecott@sussex.ac.uk

Really was fab, enjoyed it a lot

thank you so much for coming

Differentiation signals induce APOBEC3A expression via GRHL3 in squamous epithelia and squamous cell carcinoma | The EMBO Journal imageimageAPOBEC3A and APOBEC3B encode DNA editing enzymes with anti-viral roles that generate somatic mutations in cancer. This study provides insight into their expression in healthy and cancerous e...

Ok first post on Bluesky and it’s a science one… New paper out from the lab! APOBEC genes protect us from viral infection but go rogue in cancer. Here we shed new light on how these important genes are regulated, offering clues as to what goes wrong in cancer.

www.embopress.org/doi/full/10....