Joost Snijder

YouTube video by Clockwork How do Bacteria Know the Time? ｜KaiC & Circadian Clock Proteins

Full video link here:
youtu.be/fx-_2ncEi1U

🕒 NEW VIDEO 🕒

How can a cell know the time? Let's explore the beautiful 24-hour cycle produced by #KaiC proteins in the cyanobacteria S. Elongatus. Rendered in #blender3d with @bradyajohnston.bsky.social's brilliant Molecular Nodes add-on. #biology

Na 11 jaar zijn we nog geen stap dichter bij de oplossing van de woningnood Follow the Money bestaat 15 jaar. Deze weken blikken redacteuren terug op de spraakmakende onderzoeksdossiers die ze hebben opgezet. In deze vierde aflevering van de zomerreeks FTM Classics vertelt Pe...

Het woningtekort schommelt al jaren rond de 5 procent en de vraag naar woonruimte is enorm. 11 jaar geleden startten we met schrijven over de woningmarkt. In deze aflevering van FTM Classics vertelt Peter Hendriks over het dossier De nieuwe woningnood. Hoe is de markt veranderd sinds 2014?

Veel studenten zijn ‘spookhuurders’ – soms in ‘een hok van zeven vierkante meter’ Studentenhuisvesting: Door het grote tekort aan studentenkamers wonen veel studenten illegaal, met alle risico’s van dien. „Uit voorzorg proberen we de buren in het trappenhuis te mijden.”

Veel studenten zijn ‘spookhuurders’ – soms in ‘een hok van zeven vierkante meter’ www.nrc.nl/nieuws/2025/...

Stabilization of H5 highly pathogenic avian influenza hemagglutinin improves vaccine-elicited neutralizing antibody responses Transmission of highly pathogenic avian influenza from H5 clade 2.3.4.4b has expanded in recent years to infect large populations of birds and mammals, heightening the risk of a human pandemic. Influe...

🚨 New paper alert! 🚨

Here we show that stabilized influenza hemagglutinin HPAI H5 immunogens improve the quality of elicited antibody responses. Thank you to @open_phil for funding this work! bit.ly/4lgr0rM

Structural Insights into Complement Inhibition: Visualizing Distinct Binding Modes of C4b-binding Protein Complexes with C4b and SAP C4b-binding protein (C4BP) is an innate immune inhibitor found in serum. Human C4BP adopts spider-like higher-order structures (HOS) formed by disulfide-linked C4BPα and C4BPβ chains that non-covalent...

🕷️ Spiders from our blood 🕷️
Check out our new paper from @hecklab.bsky.social describing how the spider-like immune regulator C4BP interacts with its native binding partners.
🔗 www.mcponline.org/article/S153...
#MassSpec #StructuralBiology

🚨 new paper alert 🚨

Here, we present a method for designing protein nanoparticles with two unique faces that can bring together distinct biological targets at controlled distances!

This project was led by Dr. Sanela Rankovic is out now in Nature Materials: www.nature.com/articles/s41...

PDB101: Molecule of the Month: Arc An unexpected link between viruses and the brain

August's Molecule of the Month looks at an unexpected link between viruses and the brain
pdb101.rcsb.org/motm...

Respiratory viral infections awaken metastatic breast cancer cells in lungs - Nature Mouse models show that respiratory infections from viruses such as influenza and SARS-CoV-2 can trigger metastasis of dormant breast cancer cells in the lungs, a finding supported by epidemiological d...

"Respiratory viral infections awaken metastatic breast cancer cells in lungs"

www.nature.com/articles/s41...

Virion motility of sialoglycan-cleaving respiratory viruses - npj Viruses npj Viruses - Virion motility of sialoglycan-cleaving respiratory viruses

New review paper from the influenza group
@utrechtvirology.bsky.social
together with Mengying Liu and Erik de Vries on virion motility of sialoglycan-cleaving respiratory viruses through mucus and on the surface cells in NPJ viruses @natureportfolio.nature.com
doi.org/10.1038/s442...

Cryo-EM of fertilisation complex Pfs230-Pfs48/45 from malaria parasites! 💕💗

🦟 Transgenic parasites without Pfs230 D13D14 do not transmit

🦙 💉Nanobodies + mRNA induced antibodies reduce transmission

New in @Science.org

www.science.org/doi/10.1126/...

#ScienceResearch #Malaria #WEHI

Sub-3 Å resolution protein structure determination by single-particle cryo-EM at 100 keV Cryoelectron microscopy (cryo-EM) has transformed structural biology by providing high-resolution insights into biological macromolecules. We report s…

Now out in Structure: Paper on high-resolution #cryoEM using the 100 kV Tundra cryo-TEM by Dimple Karia, Adrian Koh, @abhaykot.bsky.social, @lingboyu.bsky.social, @landerlab.bsky.social and many others. Happy to have contributed to this effort. Check it out:
www.sciencedirect.com/science/arti...

Got to see DAK in Paradiso yesterday. Awesome show

Thrilled to see our study on how kinesin-2 motors are switched on and off published in @natsmb.nature.com ⚛️

➡️ www.nature.com/articles/s41...

Congrats to all authors from me and Anthony 🎉 @dunnschool.bsky.social Check out this animation made by talented PhD student @matthew-batisio.bsky.social 😆

Our lab is helping with the organisation of this year's EMBO YSF. We have a great line up of invited speakers from (mostly) the wider Baltic region & a @nightsciencepod.bsky.social workshop on creativity in science (I did it a couple of years ago, it was awesome). Please share & consider joining us!

Ångström-resolution imaging of cell-surface glycans - Nature Nanotechnology By combining bioorthogonal metabolic labelling and resolution enhancement through sequential imaging of DNA barcodes, the molecular organization of individual sugars in the native glycocalyx has been ...

New paper online:

Ångström-resolution imaging of cell-surface glycans.

The molecular organization of sugars in the native #glycocalyx has been resolved at 9 ångström using bioorthogonal metabolic labeling and #superresolution imaging of DNA barcodes.

#Glycotime

www.nature.com/articles/s41...

There have been suggestions that conflicts of interest should be clearly displayed by speakers at all times.
I've got a leak from a factory that is preparing for #ASMS2026 and they've shared their new conflict of interest outfits for the presenters. (I think @benneely.com had this idea?)
Thoughts?

3 more weeks to apply!

🧬 Fully funded PhD opportunity! 🧬

We are looking for a curious and motivated candidate to join our new team in Utrecht. Our goal is to develop biomimetic mechanisms for protein folding using DNA origami.

More info:
🔗 www.uu.nl/en/organisat...
🗓️ Deadline: 15.08

‘Minder management, meer deskundigheid'

Zomercolumn in @fd.nl

fd.nl/opinie/1563232…

New online! Finding the lock to fit the key: Ebola virus entry

The HIV-1 envelope glycoprotein: structure, function and interactions with neutralizing antibodies Nature Reviews Microbiology, Published online: 23 July 2025; doi:10.1038/s41579-025-01206-6In this Review, Klasse et al. explore the biogenesis and structure of the HIV-1 envelope glycoprotein (Env) and examine its functional role in viral entry. They also discuss how neutralizing antibodies interact with Env, the evolution of broadly neutralizing antibodies (bnAbs) and strategies to elicit bnAbs through germline-targeting immunogen design.

New online! The HIV-1 envelope glycoprotein: structure, function and interactions with neutralizing antibodies

When particles have orientation bias, the resulting maps are often streaked along the missing directions. In this case study, we cover why orientation bias produces anisotropic #cryoEM maps and how you may be able to recover from it!

guide.cryosparc.com/processing-d...

Structural insights into Measles virus RNA synthesis: C protein-mediated regulation of replication-transcription switch and allosteric inhibition by ERDRP-0519 https://www.biorxiv.org/content/10.1101/2025.07.21.666041v1

Thanks! It’s been over 40 years since it was first discovered - I wasn’t even born yet 😅

Thanks! And please do - happy to answer any questions 😉

Verkiezingsoproep aan politieke partijen Houd Nederland gezond en weerbaar investeer in wetenschap - De Jonge Akademie Actueel

Oproep aan de politieke partijen: investeer in wetenschap en laat dat zien in je verkiezingsprogramma's zodat de kiezer weet bij welke partij we moeten zijn voor een weerbare samenleving en gezonde economie!

www.dejongeakademie.nl/nieuws/30921...

We sequenced the anti-RSV-F antibody 131-2a by mass spec and determined its epitope by cryoEM. New insights in postfusion specific binding and antigenic site I. Now published in ACS Infectious Diseases @pubs.acs.org.
pubs.acs.org/doi/10.1021/...
@xdh.bsky.social @hangryhobbit.bsky.social

Higher-Throughput Proteome Profiling Enabled by Parallelized Pre-Accumulation and Optimized Ion Processing in the Orbitrap Astral Zoom Mass Spectrometer High-throughput proteomics is critical for understanding biological processes, enabling large-scale studies such as biomarker discovery and systems biology. However, current mass spectrometry technolo...

🚀 Check out our preprint on the new Thermo Scientific Orbitrap Astral Zoom MS 💫👇🏼

www.biorxiv.org/content/10.1...

Epistasis in the receptor-binding domain of contemporary H3N2 viruses that reverted to bind sialylated di-LacNAc repeats Liang et al. shows how contemporary H3N2 viruses reverted to bind sialylated di-LacNAc at the molecular level. Using complex symmetrical and asymmetric N-glycans, major epistatic interactions were rev...

Very happy that our paper on the receptor binding properties of contemporary H3N2 viruses is now published @CellReports # glycotime www.cell.com/cell-reports...

Happy to share our latest work on the structure and assembly of holocentric kinetochores! Huge thanks to Ines for a very fruitful collaboration, Claudio for all the support, and congratulations to Christine and all co-authors!

www.biorxiv.org/content/10.1...