Uli Steidl

Looking forward to the Myeloid Workshop tomorrow! 3PM, W314, @ASH. Excited about a great lineup and looking forward to intense and stimulating workshop-style discussions! And yes, the rubber chicken will be there to keep time and we will follow the traditional "Dan's Rude Rules"... 😀😊🐔

Excited to share a big milestone, the Verma Lab divijvermalab.com is now OPEN @einsteinmededu.bsky.social

We study how environmental exposures & inflammation drive stem-cell dysfunction and cancer.

Grateful to mentors Amit Verma & @steidluli.bsky.social .

We’re #NIH R01-funded lab and #hiring

👇🐔Friday, Dec 5, 3-7 PM, room: W314🐔👇

Update: The myeloid workshop is back online on the ASH webpage:
hematology.org/meetings/ann...

👇👇 Mark your calendars! Fri, Dec 5, 3-7pm @ ASH. 🐔🐔

‪Thank you! I am deeply honored and grateful to the scientific community at ISEH for receiving this award! All the brilliant, fearless, and hard-working former and current lab members who I have had the privilege to work with are the true stars here! 😊🤩 Thank you all! 🙏

Now online in Cancer Discovery @aacrjournals.bsky.social: Elevated Clonal Hematopoiesis in 9/11 First Responders Has Distinct Age-Related Patterns and Relies on IL1RAP for Clonal Expansion doi.org/10.1158/2159...

Upfront Menin-inhibitor resistance in multiply pretreated leukemias 10% of acute leukemias carry rearrangements of the KMT2A gene (Mixed-Lineage Leukemia-1, MLL-1). More than 80 fusion partners have been identified, and differences in fusion partner have been linked t...

Surprising finding that standard chemo renders AML resistant to subsequent treatment with menin inhibitors. Published in @isehsociety.bsky.social journal Exp. Hem.: www.exphem.org/article/S030...

Thank you, Ann!

Thank you, Julio!

Happy to contribute to this exciting project just published in @nature.com led by the amazing Shoichiro Takeishi in a fantastic collaboration with @steidluli.bsky.social - check out this thread 🩸 🧬

Recruiters watch out! Shoichiro is entering the faculty job market right now...

We also found that thrombopoietin has a pivotal role in determining total HSC numbers in the body, even in the context of increased niche availability. Our study provides new insights into stem cell number regulation and opens avenues of investigation into various fields. (6/6)

Moreover, HSC numbers in transplanted wild-type femurs did not exceed physiological levels when HSCs were mobilized from defective endogenous niches to the periphery, indicating that HSC numbers are constrained at the local level as well. (5/6)

To test this, we developed a femur-transplantation system, enabling us to increase HSC niche cells without adding HSCs. Surprisingly, adding niches did not increase the total HSC numbers in the body, revealing the presence of systemic mechanism(s) that limits HSC numbers. (4/6)

We and others have previously identified several HSC niche components, including mesenchymal stem cells in the bone marrow. However, their numbers significantly exceed HSC numbers, leading us to hypothesize that other regulatory mechanisms govern HSC numbers. (3/6)

HSCs play a major role in blood cell production, making the regulation of HSC numbers a central question in stem cell biology. A model from the 1970s suggested that HSC numbers are determined locally by the availability of their bone marrow microenvironments, or niches. (2/6)

Haematopoietic stem cell number is not solely defined by niche availability Nature - Haematopoietic stem cell numbers are restricted at both systemic and local levels.

Please check out this thread on our latest paper in
@nature.com on HSC pool size regulation. rdcu.be/eCJLe
Phenomenal collaboration with @gritsmanlab.bsky.social, and driven by the outstanding Shoichiro Takeishi! @einsteincellbio.bsky.social
@einsteinmededu.bsky.social (1/6)

The Myeloid Workshop is back in ASH! Please contact the organizers if you have an exciting story that will not be out by December they are: Zuzana Tothova ,
@ernstlaboratory.bsky.social
@steidluli.bsky.social
@ericpietras.bsky.social
@kathrinbernt.bsky.social
@gritsmanlab.bsky.social

Continuing our interview spotlight series is the 2025 McCulloch and Till Awardee @steidluli.bsky.social‬ Dr. Steidl discusses his current work, career inspirations and more. Watch part III on www.simplyblood.org

Our trainees had a truly enriching experience at #KUHRTN2025 at Emory, Atlanta! They gained insights into career development, received valuable advice, and enjoyed connecting with field leaders and peers from across the country. bit.ly/3H529IZ
@steidluli.bsky.social @gritsmanlab.bsky.social

Thank you, Ann!

Thank you! And proud to be part of this outstanding institute under the leadership of @jaguirreghisolab.bsky.social

Thank you, Julio! The feelings are absolutely mutual. Grateful for your friendship, input, and support!

Thanks so much, Daniel!

Thank you, Divij!

Thank you, Ravi!

I am incredibly humbled being elected into the AAP. Grateful to all the highly dedicated former and current team members and collaborators who enabled the scientific progress that led to this big honor! Also a huge thank you to my nominator and long-standing role model @jdlicht.bsky.social !

Thank you, Julio!

Congrats, Fia and Lindsay!!

📢 Support federal research funding!

As the new Administration acts & Congress finalizes FY25 funding, lawmakers need to hear from you. Share your stories of how funding & policies impact #hematology patients & research.

Take action! bit.ly/4b2bj43

#Fight4Hematology #HemeSky #BloodSky