Sarah Naguib, PhD's Avatar

Sarah Naguib, PhD

@sarahnaguib.bsky.social

Postdoc in @liganlab.bluesky.social at Weill Cornell Medicine interested in resilience and microglia in neurodegeneration • Vanderbilt Neuro PhD ‘22 • Kenyon College ‘17 • 1st gen Egyptian-American

290 Followers  |  712 Following  |  13 Posts  |  Joined: 08.04.2025
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Posts by Sarah Naguib, PhD (@sarahnaguib.bsky.social)

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Network with stem cell leaders at ISSCR 2026. Learn more.

#ISSCR2026 offers exclusive networking opportunities designed to connect you with researchers driving the future of stem cell science. Make connections that progress your research forward and join me at @ISSCR.org 2026 in Montréal, Canada this July. invt.io/1bxbpbz4ntg

02.03.2026 15:42 — 👍 0    🔁 0    💬 0    📌 0
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ISSCR 2026 abstract submission ends 25 February. Learn more.

Open doors to new collaborations, mentorship, and global recognition in the stem cell community by presenting your research at #ISSCR2026. Abstracts are due 25 February to be considered for oral presentations and travel & merit awards. invt.io/1bxbqnagnog @isscr.org

16.02.2026 14:18 — 👍 1    🔁 1    💬 0    📌 0
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ISSCR 2026 abstract submission ends 25 February. Learn more.

The #ISSCR2026 scientific program brings together leading voices and new ideas, covering a wide range of topics from stem cell biology to organoids, disease modeling, and cell therapies. Submit an abstract by 25 February for the opportunity to present your research! invt.io/1bxbe647k59 @isscr.org

02.02.2026 14:52 — 👍 4    🔁 1    💬 0    📌 0
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Submit a Science Spotlight Proposal by 25 February. Learn more.

Submit a science spotlight proposal to contribute to the scientific programming at #ISSCR2026! Organized by @ISSCR.org student & postdoc members, these sessions provide a fresh perspective on emerging scientific topics. Proposals are due 25 February invt.io/1bxb71pvmxv

19.01.2026 17:13 — 👍 3    🔁 1    💬 0    📌 0
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Transplantation of Human IPSC-derived Microglia Ameliorates Neuropathology and Circuit Dysfunction in Progranulin-Deficient Mice Frontotemporal dementia (FTD) is a major cause of early-onset neurodegeneration characterized by progressive behavioral, emotional, and cognitive decline. Progranulin haploinsufficiency, a leading gen...

Proud to announce our collaboration with @blurtonjoneslab.bsky.social & the Paz lab showing that transplanted human iPSC-derived microglia in a PGRN KO mouse model restores progranulin in microglia and rescues pathology, circuitry, and behavior. Preprint out now: www.biorxiv.org/cgi/content/...

14.01.2026 18:57 — 👍 14    🔁 8    💬 0    📌 0
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Transplantation of Human IPSC-derived Microglia Ameliorates Neuropathology and Circuit Dysfunction in Progranulin-Deficient Mice Frontotemporal dementia (FTD) is a major cause of early-onset neurodegeneration characterized by progressive behavioral, emotional, and cognitive decline. Progranulin haploinsufficiency, a leading gen...

Proud to co-lead this study with @blurtonjoneslab.bsky.social & the Paz lab showing that transplanted human iPSC-derived microglia in a PGRN KO mouse model restores progranulin and rescues pathology, circuitry, and behavior. Preprint out now: @liganlab.bsky.social
www.biorxiv.org/content/10.6...

14.01.2026 18:52 — 👍 4    🔁 0    💬 0    📌 0
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Submit an Abstract by 25 February. Learn more.

The abstract submission deadline for #ISSCR2026 is coming up on 25 February! Submit your research to showcase your findings, connect with global experts, and gain visibility. Travel awards are available for early career researchers. Learn more: invt.io/1bxbxzw17hu @ISSCR.org

05.01.2026 16:06 — 👍 2    🔁 1    💬 0    📌 0
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Join me at the ISSCR 2026 Annual Meeting! Register now

The #ISSCR2026 scientific program features the field’s most influential voices and groundbreaking science. Explore breakthroughs from basic biology to clinical translation and join the conversations driving stem cell research and regenerative medicine forward. invt.io/1bxbvudgat1 @isscr.org

15.12.2025 15:46 — 👍 2    🔁 1    💬 0    📌 0
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Join me at the ISSCR 2026 Annual Meeting! Register now

Showcase your research on a global stage at #ISSCR2026! Submit an abstract by 25 February to share your latest stem cell discoveries, translational insights, or clinical advances. Research from all sectors is welcome - academia, industry, and beyond! invt.io/1bxbf5ww2b1 @ISSCR.org

01.12.2025 21:58 — 👍 3    🔁 1    💬 0    📌 0
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Join me at the ISSCR 2026 Annual Meeting! Register now

@stemcellreports.bsky.social, the official meeting journal of #ISSCR2026, communicates basic discoveries in stem cell research, in addition to translational & clinical studies. Meet the editorial team at @ISSCR.org 2026 & discuss how to publish your work in Stem Cell Reports! invt.io/1bxbvzmjckk

17.11.2025 16:53 — 👍 4    🔁 2    💬 0    📌 0
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Join me at the ISSCR 2026 Annual Meeting! Register now

There are many ways to make your voice heard and participate in all that #ISSCR2026 has to offer! Discover how to get involved, including submitting an abstract, proposing a science spotlight, hosting a meet-up hub, and more! invt.io/1bxbscfory3 @ISSCR.org

03.11.2025 20:59 — 👍 2    🔁 1    💬 0    📌 0
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I'm an ISSCR 2026 Ambassador, join me! Register now

Thrilled to be selected as an #ISSCR2026 Ambassador! The @ISSCR.org 2026 Annual Meeting will take place in Montréal, Canada on 8-11 July 2026 & features 4 days of scientific sessions with talks from global researchers! Explore the scientific program and the ways to participate. invt.io/1bxbah1l97q

27.10.2025 17:04 — 👍 5    🔁 1    💬 0    📌 0
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🏆🏆🏆 CONGRATULATIONS to the winner of the PBL Assay Science Best Speaker Award Sarah Naguib @sarahnaguib.bsky.social

Title: Elucidating the neuroprotective mechanisms of human microglial replacement therapy in FTD and PD

Thank you PBL Assay Science for sponsoring the award

26.08.2025 18:01 — 👍 2    🔁 2    💬 0    📌 0
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Microglia replacement halts the progression of microgliopathy in mice and humans Colony-stimulating factor 1 receptor (CSF1R) is primarily expressed in microglia. Its monoallelic mutation causes CSF1R-associated microgliopathy (CAMP), a major form of adult-onset leukoencephalopath...

Microglia replacement halts the progression of microgliopathy in mice and humans @science.org www.science.org/doi/10.1126/...

10.07.2025 19:01 — 👍 30    🔁 11    💬 2    📌 1
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Scientists warn US will lose a generation of talent because of Trump cuts Political interference and chaotic cuts to staff, programs and grants at the National Science Foundation are producing ‘devastating consequences’

By me: A generation of scientific talent is at the brink of being lost to overseas competitors by the Trump administration’s dismantling of the National Science Foundation (NSF), with unprecedented political interference jeopardizing the future of US enterprise.

www.theguardian.com/us-news/2025...

03.07.2025 11:58 — 👍 132    🔁 66    💬 9    📌 8

Could not be more proud and excited for @sadafamin.bsky.social as she begins her own lab at
@washumedicine.bsky.social very soon! Sadaf has been an amazing mentor, colleague and most importantly, friend, in our time in the @liganlab.bsky.social and I can't wait to see her succeed as a PI 🧠🔬❤️🧪😊

01.07.2025 20:29 — 👍 4    🔁 0    💬 1    📌 0

So proud to share my first first-author paper from my postdoc in @liganlab.bsky.social out yesterday in
@cp-immunity.bsky.social! We characterized a model of the APOE3 Christchurch mutation on a tauopathy background and found downregulation of cGAS-STING-IFN pathway as a source of protection!

24.06.2025 18:04 — 👍 29    🔁 8    💬 2    📌 0
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The R136S mutation in the APOE3 gene confers resilience against tau pathology via inhibition of the cGAS-STING-IFN pathway The Christchurch mutation (R136S) in the APOE3 (E3S/S) gene is associated with attenuated tau load and cognitive decline despite the presence of a cau…

🚨Our new paper is out!🚨 We uncover a protective mechanism of the rare APOE3 Christchurch (R136S) mutation against tauopathy—by suppressing microglial cGAS–STING–interferon (IFN) pathway, a key inflammatory axis triggered by tau. www.sciencedirect.com/science/arti...

24.06.2025 12:57 — 👍 48    🔁 16    💬 3    📌 4
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The R136S mutation in the APOE3 gene confers resilience against tau pathology via inhibition of the cGAS-STING-IFN pathway The APOE3 Christchurch mutation (R136S) reduces tau pathology despite the PSEN1 mutation and high amyloid, though its protective mechanism remains unclear. Naguib et al. show that R136S suppresses microglial cGAS-STING-IFN signaling in tauopathy mice. Inhibiting cGAS preserves synapses and mimics R136S-linked gene expression, suggesting that cGAS suppression is a key part of the underlying protective effects of R136S.

Online now: The R136S mutation in the APOE3 gene confers resilience against tau pathology via inhibition of the cGAS-STING-IFN pathway

23.06.2025 14:48 — 👍 4    🔁 2    💬 1    📌 0