Sarah Naguib, PhD

Microglia replacement halts the progression of microgliopathy in mice and humans Colony-stimulating factor 1 receptor (CSF1R) is primarily expressed in microglia. Its monoallelic mutation causes CSF1R-associated microgliopathy (CAMP), a major form of adult-onset leukoencephalopath...

Microglia replacement halts the progression of microgliopathy in mice and humans @science.org www.science.org/doi/10.1126/...

Scientists warn US will lose a generation of talent because of Trump cuts Political interference and chaotic cuts to staff, programs and grants at the National Science Foundation are producing ‘devastating consequences’

By me: A generation of scientific talent is at the brink of being lost to overseas competitors by the Trump administration’s dismantling of the National Science Foundation (NSF), with unprecedented political interference jeopardizing the future of US enterprise.

www.theguardian.com/us-news/2025...

Could not be more proud and excited for @sadafamin.bsky.social as she begins her own lab at
@washumedicine.bsky.social very soon! Sadaf has been an amazing mentor, colleague and most importantly, friend, in our time in the @liganlab.bsky.social and I can't wait to see her succeed as a PI 🧠🔬❤️🧪😊

So proud to share my first first-author paper from my postdoc in @liganlab.bsky.social out yesterday in
@cp-immunity.bsky.social! We characterized a model of the APOE3 Christchurch mutation on a tauopathy background and found downregulation of cGAS-STING-IFN pathway as a source of protection!

The R136S mutation in the APOE3 gene confers resilience against tau pathology via inhibition of the cGAS-STING-IFN pathway The Christchurch mutation (R136S) in the APOE3 (E3S/S) gene is associated with attenuated tau load and cognitive decline despite the presence of a cau…

🚨Our new paper is out!🚨 We uncover a protective mechanism of the rare APOE3 Christchurch (R136S) mutation against tauopathy—by suppressing microglial cGAS–STING–interferon (IFN) pathway, a key inflammatory axis triggered by tau. www.sciencedirect.com/science/arti...

The R136S mutation in the APOE3 gene confers resilience against tau pathology via inhibition of the cGAS-STING-IFN pathway The APOE3 Christchurch mutation (R136S) reduces tau pathology despite the PSEN1 mutation and high amyloid, though its protective mechanism remains unclear. Naguib et al. show that R136S suppresses microglial cGAS-STING-IFN signaling in tauopathy mice. Inhibiting cGAS preserves synapses and mimics R136S-linked gene expression, suggesting that cGAS suppression is a key part of the underlying protective effects of R136S.

Online now: The R136S mutation in the APOE3 gene confers resilience against tau pathology via inhibition of the cGAS-STING-IFN pathway