The French DC Society - Club Francophone des DC (CFCD)

Cohesin-mediated chromatin organization controls the differentiation and function of dendritic cells Chromatin-organizing cohesin complex cooperates with transcription factor IRF8 to enable the functionality of dendritic cells in vivo.

Another paper out this week in @scienceimmuno.bsky.social by the Reizis laboratory showing that "Cohesin-mediated chromatin organization controls the differentiation and function of dendritic cells" Congrats 👏https://www.science.org/doi/10.1126/sciimmunol.adx4622

Transcription factor Etv3 controls the tolerogenic function of dendritic cells Dendritic cells (DCs) facilitate the maintenance of immunological tolerance in the steady state. We report that transcription factor Etv3 is preferentially expressed in mature DCs, including tissue-de...

Congrats to the Reizis lab for this beautiful paper in @science.org identifying the "transcription factor Etv3 as controling the tolerogenic function of dendritic cells"
www.science.org/doi/10.1126/...

TSLP promotes GATA3-expressing effector regulatory T cells via DC2 derived from transitional DCs - Nature Immunology Recent work has revealed that dendritic cells (DCs) are more heterogeneous than previously thought, yet the functional roles of these newly described DC subsets remain unclear. Here, Li et al. find th...

Congrats to Mei Li and team for this nice story in @natimmunol.nature.com showing "that TSLP from keratinocytes activates transitional DC-derived DC2 to promote GATA3+ regulatory T cells and mediate immunosuppression during inflammation and cancer".

www.nature.com/articles/s41...

The differentiation and function of heterogeneous thymic dendritic cell subsets require signals provided by distinct thymocyte cell types - Nature Immunology Dendritic cells (DCs) are required to establish thymic central tolerance. Here Srinivasan et al. use single-cell transcriptomics to define thymic conventional dendritic cell (cDC) subsets and find tha...

Really nice study in @natimmunol.nature.com dissecting thymic DC subsets and demonstrating that crosstalk with thymocytes is essential for thymic DC activation, maturation, and function.
www.nature.com/articles/s41...

@salva-iborra.bsky.social and Co in @jem.org elegantly sow that plasmacytoid DCs expand tissue-resident memory CD8+ T cell responses during viral reinfection

rupress.org/jem/article/...

In @nature.com the team of E.G Engleman shows that Erythropoietin receptor on cDC1s dictates their ability to induce immune tolerance.

www.nature.com/articles/s41...

Very interesting work in @jem.org showing an important role of Claudin 1 expression by thymic conventional DC1 for the maintenance of central tolerance.

rupress.org/jem/article/...

DNA-damaging chemotherapy reshapes cardiac-resident macrophage composition and function Carboplatin reshapes macrophages to protect the heart through type I IFN signaling in mouse models.

DNA-damaging chemotherapy leads to repopulation of the resident cardiac macrophage population, protecting the heart against injury in mice.

Learn more in #ScienceImmunology: https://scim.ag/49gYQJg

Cross-presentation of dead cell-associated antigens shapes the neoantigenic landscape of tumor immunity - Nature Immunology Here the authors show DNGR-1 expressed by cDC1s promotes CD8⁺ T cell priming to cytoskeletal neoantigens from dying tumor cells, thereby shaping cancer immune visibility and tumor evolution through im...

Congrats to the team of @reisesousalab.bsky.social for this beautiful work in @natimmunol.nature.com showing that "Neoantigen cross-presentation by cDC1 can determine the immune visibility of the tumor mutational landscape and sculpt cancer evolution by immunoediting"

www.nature.com/articles/s41...

Cross-presentation of dead cell-associated antigens shapes the neoantigenic landscape of tumor immunity - Nature Immunology Here the authors show DNGR-1 expressed by cDC1s promotes CD8⁺ T cell priming to cytoskeletal neoantigens from dying tumor cells, thereby shaping cancer immune visibility and tumor evolution through im...

@drjonlim.bsky.social & @reisesousalab.bsky.social show cDC1s & DNGR1 favor "tethered" neoantigens from F-actin proteins, trapping them in necrotic debris for better cross-presentation! Calls for prioritizing these neoantigens for cancer vaccine design #Immunotherapy www.nature.com/articles/s41...

Sideways lipid presentation by the antigen-presenting molecule CD1c @natcomms.nature.com @monashuniversity.bsky.social
www.nature.com/articles/s41...

Positioning and reversible suppression of CCR7+ dendritic cells in perivascular tumor niches shape cancer immunity @cp-immunity.bsky.social @beatricezitti.bsky.social @biology-unige.bsky.social
www.cell.com/immunity/ful...

The French DC society started with a session on intestinal tolerance induction by specialised subset of antigen presenting cells (Thetis Cell aka Tol DCs, aka Rorgt APC...) by @chrysothemisbrown.bsky.social, Rab iUPADHYAY and Helena Paidassi.

🚨 This Thursday the biennial meeting of the French DCs society at the institut Curie in Paris will start🚨.
Some last seats are available if interested...
Registration and Final Program here: www.cfcd.fr/meeting/prog...

IL-10–producing tolerogenic DC dampen B cell responses via T cell inhibition, offering a targeted strategy for specific B cell modulation
www.science.org/doi/10.1126/...

Tonic type I interferon signaling optimizes the antiviral function of plasmacytoid dendritic cells - Nature Immunology Pucella, Maqueda-Alfaro and colleagues distinguish three developmentally related subsets of mouse plasmacytoid dendritic cells that differ in their ability to produce type I interferon and their susce...

Fascinating new study from the B. Reizis group in @natimmunol.nature.com

Tonic type I IFN signaling restrains pDC cytokine production & survival — yet makes them tougher against viruses.
👉 A fine-tuned balance for optimal antiviral immunity

www.nature.com/articles/s41...

🚨 The early bird registration deadline for the French DC Society meeting has been extended to October 24th, 2025!

Don’t miss the chance — register now!

Registration👇
docs.google.com/forms/d/e/1F...

Program 👇
www.cfcd.fr/meeting/prog...

🚨 Postdoc Opportunity – Pathogen-Host Interaction 🚨 (2.5y)

🦠 Join our team to uncover the molecular mechanisms of Y. pestis infection in fleas within a @anrs-mie.bsky.social PEPR-funded project!

🔬 Profile: PhD in microbiology

#Postdoc #Microbiology #YersiniaPestis #ResearchJobs

⏰ Only until 15 Oct 2025 to submit your abstract & grab early-bird registration!

Join us in Paris for the French DCs Meeting — featuring an outstanding speaker lineup.

Program 👇
www.cfcd.fr/meeting/prog...

Registration 👇
docs.google.com/forms/d/e/1F...

#DCMeeting2025 #Immunology

Plasmacytoid dendritic cells are dispensable or detrimental in murine systemic or respiratory viral infections - Nature Immunology Previous research has suggested that pDCs are required for an effective antiviral immune response, but direct experimental evidence to support this is lacking. Here Ngo et al. develop a pDC knockin mouse model and find that pDCs are dispensable for an antiviral immune response to mouse cytomegalovirus and may be detrimental during influenza or SARS-CoV-2 infection.

E. Tomasello & team at @ciml.bsky.social challenge the prevailing dogma of plasmacytoid DC's role in anti-viral immunity, by showing that they are deleterious in respiratory viral infections.

CONGRATS 🍾 can't wait to hear more about it the next French DC society meeting👇
www.cfcd.fr/meeting/prog...

🚨A new study in @elife.bsky.social "reveals crucial roles of cDC1 in atherosclerosis progression and provides insights into the development of therapies by targeting cDC1 through Xcl1"🚨
👇👇

elifesciences.org/articles/107...

The 8th Symposium of the French Network on Monocytes-Macrophages (SoMM2025), will take place in Lyon, France, on November 7th, 2025

📝 Registration (free but mandatory) and abstract submission are now open until October 10th, 2025 : somm2025.sciencesconf.org

Amazing line up
👇👇👇

A targetable epigenetic node of myeloid progenitor dysregulation that sustains immunosuppressive lung tumor microenvironment, a target for improving immunotherapy outcomes @nature.com @miriammerad.bsky.social
@sinaiimmuno.bsky.social
www.nature.com/articles/s41...

Left: Representative samples from the cervical (a + b), thoracic (c + d), and sacral (e + f) spinal cord comparing the degree of inflammation and white matter damage in control (a, c, e) and cKO (b, d, f) mice. Arrowheads mark foci with lymphocytic-dominant infiltration. In some cases, the infiltrate is associated with white matter damage, seen as pallor at this magnification. Right: Suggested model, created using Biorender.

Myeloid cells drive #neuroinflammation in #MultipleSclerosis by promoting immune activation in the #CentralNervousSystem. This study identifies SLAMF5 as a key myeloid receptor that regulates this process, showing that its blockade reduces disease progression @plosbiology.org 🧪 plos.io/3Vb7xhx

FEBS | EMBO Women in Science Award 2026 for Carola García de Vinuesa – Press releases – EMBO She is recognized for advancing the understanding of autoimmune diseases and bringing science into the public eye

Congratulations to Carola García de Vinuesa on receiving the 2026 FEBS | EMBO #WomenInScience Award! She is recognized for advancing the understanding of autoimmune diseases and for her impact within the #LifeSciences community, in particular in public engagement: www.embo.org/press-releas... 🧪

Combined Flt3L and CD40 agonism restores dendritic cell–driven T cell immunity in pancreatic cancer Flt3L and CD40 agonism enhance dendritic cell immunosurveillance in human and murine pancreatic cancer and engage type I immunity.

Exciting work in @scienceimmuno.bsky.social : boosting Dendritic Cells with FLT3L + CD40 agonists reactivates T cell immunity in pancreatic cancer—shown in both mice and patients.
👇
www.science.org/doi/10.1126/...

Fantastic new story @jkagan1.bsky.social & friends showing that human dendritic cells can become hyperactive activating the inflammasome without dying, & that this approach can be used in mice and NHPs to potentiate anti-influenza vaccine responses! 👇👇👇

TNF and type I interferon crosstalk controls the fate and function of plasmacytoid dendritic cells - Nature Immunology Plasmacytoid dendritic cells are type 1 interferon (IFN-I)-producing antiviral specialists that have been shown to be able to differentiate into conventional dendritic cells. Here the authors show how...

🚨 New in @natimmunol.nature.com : @idoyagalab.bsky.social shows that plasmacytoid DCs can reprogram into cDC2s after TNF-α stimulation. Fascinating plasticity!
👇

www.nature.com/articles/s41...

DNASE1L3-expressing dendritic cells promote CD8+ T cell function and anti-PD-(L)1 therapy efficacy by degrading neutrophil extracellular traps Chen et al. demonstrate that DNASE1L3+ dendritic cells degrade neutrophil extracellular traps, thereby facilitating CD8+ T cell infiltration, effector function, and cytotoxic hub formation within the ...

🤯 By spitting out DNASE1L3, Dendritic Cells chew up NETs and make immunotherapy hit harder against tumors.
Cool science in @cp-cancercell.bsky.social 🧬✨

www.cell.com/cancer-cell/...

#Dendritic #Immunology #CancerResearch

Anchored screening identifies transcription factor blueprints underlying dendritic cell diversity and subset-specific anti-tumor immunity Transcription factors are known to guide dendritic cell identity, but how they cooperate to drive lineage diversification remains unclear. Henriques-Oliveira, Altman, Kurochkin, et al. identify two tr...

The laboratory of Filipe Pereira @lunduniversity.bsky.social in @cp-immunity.bsky.social "uncover transcriptional circuits that control DC diversification"

Very cool approach and can't wait to hear more about it the next French DC society meeting👇
www.cfcd.fr/meeting/prog...