Alex Whitworth lab

LRRK2 integrates Rab and GABARAP interactions to sense and respond to distinct lysosomal stresses Increased activity of leucine-rich repeat kinase 2 (LRRK2) is an important risk factor for Parkinson’s disease. LRRK2 localizes to lysosomal membranes, and changes in lysosome physiology are emerging ...

New research led by Devin Clegg that defines how lysosome swelling and lysosome deacidification evoke distinct routes for LRRK2 activation: doi.org/10.1101/2025...

This is a great paper. Congrats to Derek and the whole team.

Looks like mitochondrial depolarisation is a bone fide PINK1-activating mechanism after all.

Next question: when does this occur at scale in neurobiology?

New paper - MAPL strikes again! Interested in mitochondrial signalling, inflammation, lysosome biology, pyroptosis, and Parkinson's disease? Have a look, there's something for everyone! Feeling grateful! @mitocollier.bsky.social Funded by #CIHR, @asapresearch.parkinsonsroadmap.org.
rdcu.be/eKKz1 🇨🇦

Having fun enthusing young and old, expert and novice, about our mitochondria research at Cambridge’s Big Biology Day #PublicEngagement #Outreach @mrc-mbu.bsky.social

Amazing work @frisophagy.bsky.social and all the Chinnery lab team.

Oh, this is sad. A great scientist and great (and modest) human being. I’m very proud that he once told me he liked my talk at the end. High praise indeed.

A montage of images of sixth form students in a Cambridge research lab

Applications now open for our work experience programme for year 12 students, run with @mrc-mbu.bsky.social & @stcatharines.bsky.social We give students a valuable insight into life as a research scientist and student in Cambridge. Details & application link here: www.cimr.cam.ac.uk/inspiring-sc...

Postdoctoral Research Associate - Neurodegeneration An exciting opportunity to join the Snow Vision Accelerator Location: Loreto Group, Axon degeneration Lab, School of Medical Sciences, Charles Perkins Centre, Faculty of Medicine and Health Full time,...

🌟 We’re hiring a Postdoctoral Fellow! 🌟

Join my lab @sydney.edu.au and help drive cutting-edge research in axon degeneration as part of the Snow Vision Accelerator.
@snowmedical.bsky.social

usyd.wd105.myworkdayjobs.com/en-GB/USYD_E...

Do you need help with mitochondrial image analysis? 🔬

Check out mitographica.com created by
Dane M Wolf

Find out more from his interview on MitoWorld
mitoworld.org/mitochondria...

Proud that this being pioneered in the UK 💪

Clu1/Clu form mitochondria-associated granules upon metabolic transitions and regulate mitochondrial protein translation via ribosome interactions Author summary Mitochondria are essential cellular organelles that perform many important roles in regulating metabolism. They are dynamic in form, function and composition which is crucial to maintai...

Delighted to share our latest work looking at the role of the RNA-binding proteins Clu1 (yeast)/Clu (flies) in regulating the translation of #mitochondria proteins. Really interesting regulator of mito biology.

Huge, long-running effort by PDRA Leonor Miller-Fleming 👏
dx.plos.org/10.1371/jour...

Ha. This is so accurate to how I’m spending my days.

We were shocked and disappointed to learn of the allegations made about Raynor and Moth Winn by The Observer. The article has taken everyone by surprise and has made people affected by CBD & PSP feel angry, let down and eager for clarity. Full statement: www.pspassociation.org.uk/news/pspas-r...

This is quite shocking and saddening if true.

“Do you have any advice for aspiring young scientists?”

“Do genetics.” *mic drop*

#worm25

Enhancing autophagy by redox regulation extends lifespan in Drosophila - Nature Communications Redox signalling is emerging as an important regulator of metabolism and physiology, which is dysregulated in ageing and disease. Here, the authors show that redox regulation of a key redox sensitive ...

🎉Excited to share our latest paper, published in Nature Communications!🎉

"Enhancing autophagy by redox regulation extends lifespan in Drosophila"

#redox #metabolism #ageing #Drosophila

@natcomms.nature.com @mrc-lms.bsky.social

doi.org/10.1038/s414...

Check out the #LMSnews story on the @mrc-lms.bsky.social website about our latest study published in @natcomms.nature.com!

Illustrated by multi-talented first author #postdoc #painter @claudialennicke.bsky.social 💛 #redox #cysteine #sciart

Delighted to announce Prof Miratul Muqit as Centre Director of our groundbreaking new Parkinson's Research Centre, a partnership with @parkinsons.org.uk!🎉👏

Prof Muqit is a world leader in Parkinson’s research, having made major contributions to understanding genetic risk👉 buff.ly/etNUa4b

Very useful overview, especially for the Drosophila-curious.

It’s easy to bring the power of fly genetics to your neurobiology questions.

www.mrc-mbu.cam.ac.uk/news/judy-hi...

This week I will be finally presenting my postdoc data in an exciting webinar on #ubiquitin biology, together with an old classmate of mine.

If your interested, follow the link below

I see. Good to know, and thanks for your community spirit

Send them to BDSC

Great post doc opportunity 👇

Thank you @crisprflydesign.bsky.social for continuing to develop cutting edge tools that help maintain #Drosophila as still the best animal model for genetic manipulation

Yes! Join the network, folk. It’s fun

Want to understand how mitochondrial disruptions lead to neurodenegeneration?
We have an ideal opening for a new graduate or experienced research assistant.

Looking for skills in molecular and cell biology, microscopy, and experience with #Drosophila would be a plus.

Just a few days left to 👇👇

Fly Open access research on Drosophila developmental/evolutionary biology, organogenesis, neurobiology, circadian rhythms, learning & memory, sex determination

Fly journal is now on BlueSky! The world’s only academic journal dedicated to research on Drosophila & cognate insects. A fully open-access journal that combines rapid publication with high standards of peer-review. For further info and how to submit your work, see the link.

📣Job alert🎉

Want to join a dynamic team investigating mitochondria in neurodegeneration in Cambridge @mrc-mbu.bsky.social? Keen to use the power of fly genetics?

We’re recruiting a Research Assistant from July. Perfect for a finishing under/postgrad.

Get in touch!
www.jobs.cam.ac.uk/job/50944/

Well, who knows what bs to believe any more?
This must be the government efficiency Musk was going for.