European Headache Federation

The International Headache Society’s new position statement highlights the importance of early migraine prevention. It recommends considering preventive therapy from 2–4 monthly migraine days and underscores the need for studies to evaluate early intervention benefits: doi.org/10.1177/0333...

New meta-analysis found no clear link between migraine and overall, cardiovascular, or suicide-related mortality. Some studies identified a link between women with migraine aura and increased cardiovascular risk, highlighting the need for more research and sex-specific risks doi.org/10.1186/s101...

Women with migraine show higher serum levels of CGRP, a key migraine-related molecule, compared to healthy controls. A CGRP level above 40 pg/mL was linked to more frequent attacks and greater pain sensitivity. Links between CGRP and rimegepant response were identified: doi.org/10.1186/s101...

New study: Men with migraine are much less likely than women to get the right diagnosis before seeing a specialist (57% vs 74%). Women often show classic migraine signs, while men have less typical symptoms—leading to missed or delayed care. doi.org/10.1186/s101...

🧠New insight into migraine and inflammation: results from a large systematic review and meta-analysis (57 studies, ~2 850 migraine patients) reveals that different inflammatory markers are associated with different migraine states.

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🧠 New research suggests a promising approach for post-traumatic headache (PTH) relief!

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This new meta-analysis reveals how the brain’s electrical activity changes across migraine phases in Hemiplegic migraine👇
⚡ Aura: 71% show low-amplitude EEG on the opposite side of paralysis
⚡ Headache/Post-headache: slowing in the same region
⚡ Interictal: 79% normal EEG

doi.org/10.1186/s101...

We have extended the late breaking abstract deadline to 10 October!

Whether you are working on innovative treatments, new clinical data, or emerging insights in headache and migraine research, we want to hear from you.

📢 Submit your abstract today: headache-congress.org/programme-ab...

#EHC25

Headaches are widespread but under-recognised in the German military: 95% had headaches last year, 27% migraine, 29% probable migraine. 64% lost workdays; migraineurs ~4 days/month. Most had no diagnosis & few used preventives. Better screening & care needed. Read more: doi.org/10.1177/0333...

Spreading depolarization triggers migraine-like facial pain and anxiety in a model. Oral atogepant, a CGRP receptor blocker, reduces pain and eliminates grimace responses, while also improving anxiety-like behavior, highlighting its potential for migraine treatment. doi.org/10.1186/s101...

New methods in awake models are improving our understanding of spreading depolarization, key in migraine with aura. Techniques like optogenetics, wireless telemetry, and two-photon imaging enable minimally invasive, long-term monitoring, bridging the gap to human studies. doi.org/10.1186/s101...

📢 Call for Papers – Journal of Headache and Pain
Submit your work to our new collections:
🧠 Pain in Neurodegenerative Diseases
🧬 Epigenome & Transcriptome in Headache
💊 Community Pharmacy & Headache Care
Help shape the future of headache research.
🔗 thejournalofheadacheandpain.biomedcentral.com

Epigenetic changes in the RONS-TRPA1-CGRP pathway may shape migraine susceptibility, chronification, and treatment response. Insights from a narrative review.

doi.org/10.1186/s101...

🔬 New Tool in Migraine Care: The “CGRP Score” Nomogram. This ML-based predictive score achieved a good performance in identifying responders to anti-CGRP mAbs. The nomogram has the potential to be a practical, user-friendly tool for supporting clinical decision-making.

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🤖💡 AI is reshaping how we approach headache care. A systematic review of 76 studies highlights progress in diagnosis, treatment prediction, and digital health monitoring.

But major challenges remain. So, AI should augment—not replace—the doctor–patient relationship.

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From AI applications to clinical strategies and translational research, #EHC25 offers a rich, engaging, and practice-relevant experience.

Get a first look and start planning your personal highlights: headache-congress.org/programme-ab...

#EHC25 #headachecongress #EHF #headache #migraine

This year’s programme features high-level plenaries, cutting-edge debate sessions, interactive teaching courses, and forward-looking updates – all under the theme “Transforming Challenges into Solutions”.

Late breaking abstracts are open – perfect for those last-minute discoveries!
You have groundbreaking results or fresh insights to share? Submit your late breaking abstract now & showcase your latest research to a global audience.
🗓️ Deadline: 29 September 2025
🔗 headache-congress.org/programme-ab...

Established molecular triggers reliably induce extracerebral arterial dilation, an effect reversed by sumatriptan. These findings support the hypothesis that sustained meningeal vasodilation might contribute causally to #migraine pathogenesis.

Read more here: rdcu.be/eCJA3

Longitudinal assessment of #migraine burden in resistant and refractory migraine – Data from the prospective REFINE study.

While both ResM and RefM reflect high migraine disability burden, they might present relevant differences in their management and prognosis.

rdcu.be/eB8lD

Trigeminal neuralgia affects brain-wide networks—not just facial pain areas. Patients show reduced brain flexibility and control, especially with age. Evidence suggests it is a whole-network disorder, not a local one. Read the article: doi.org/10.1186/s101...

In a mouse model of post-traumatic headache, anti-CGRP mAb partly reduced pain if given around injury—but fully blocked it if given before headache triggers. Timing matters! Read the full study: doi.org/10.1186/s101...

A study analysing patient reports of face and jaw pain found key concerns like work limits, sleep issues, and the need for clear diagnosis. Using language analysis tools can help doctors better understand what patients are going through. Read the study: doi.org/10.1186/s101...

The Journal of Headache and Pain has grown into a global leader, with 50% new authors in 2024 and strong support for early-career researchers. But access to innovative treatments still lags behind global needs. Read the blog post here: communities.springernature.com/posts/the-jo...

Migraine and depression often co-occur—and new research suggests they may share underlying biological causes. Understanding these links could lead to better, combined treatments, read more here: doi.org/10.1186/s101...

💡 Ready to move from theory to practice?
Join our practical teaching sessions during the 19th European Headache Congress and elevate your skills with expert guidance.
📅 Limited slots available – book now as part of your #EHC25 registration!
ℹ️ headache-congress.org/programme-ab...

A 2024 Japanese study found 3.9% of women with headaches avoided pregnancy due to their condition. Those with higher headache burden, more symptoms (nausea, phonophobia), and med concerns were most affected. Headache disorders can impact fertility decisions. doi.org/10.1186/s101...

Have you planned your trip to #EHC25?
We are certain that Lisbon, a city of light, sea & endless discovery, will captivate your senses. With every street telling a unique story, Lisbon promises to surprise and delight you at every corner.
ℹ️ Travel & hotels: headache-congress.org/travel-hotels

Central structural changes in TN extend beyond traditional pain regions. Future research should consider the role of visual and integrative cortical areas in chronic trigeminal pain as possible neuroplastic adaptations to persistent nociceptive input.

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This interesting retrospective observational study examined patients with chronic migraines who received treatment with either eptinezumab or onabotulinumtoxinA for six months, providing a rationale for larger, real-world studies.

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