Some really cool work we've been doing @oliolabs.bsky.social. New science opens the door to better medicines.

19.03.2025 22:16 — 👍 7    🔁 1    💬 1    📌 0

We are building our platforms to solve these problems, and deliver better outcomes with fewer side effects to more people. Get in touch if you want to be a part of our vision. www.oliolabs.co

19.03.2025 19:27 — 👍 0    🔁 0    💬 0    📌 0

https://www.prnewswire.com/news-releases/landmark-study-explains-why-obesity-drugs-work-differently-for-women-and-men-302406164.html

Check out a write up of the results here:
t.co/ZYakrIhPTE

Link to PDF here:
t.co/VwqiZ46eHU

19.03.2025 19:27 — 👍 0    🔁 0    💬 1    📌 0

We also found that side effects fluctuate with estrogen levels and estrous cycle phases in humans and mice respectively

19.03.2025 19:27 — 👍 0    🔁 0    💬 1    📌 0

GLP-1 receptor expression is higher in females than males in parts of the brain associated with pain and nausea

19.03.2025 19:27 — 👍 0    🔁 0    💬 1    📌 0

Female rats and mice display significantly more nausea-associated behavior compared to males (Kaolin intake is a measure of nausea in rats)

19.03.2025 19:27 — 👍 0    🔁 0    💬 1    📌 0

Women taking GLP1-R agonists experience more than twice the rate of persistent nausea and vomiting compared to men

19.03.2025 19:27 — 👍 0    🔁 0    💬 1    📌 0

Check out what we're working on at Olio Labs!

70% of patients taking GLP-1's (like Ozempic) are women, but they experience >2x side effect rates than men.

What is driving this difference?

We combine human EMR data, mouse & rat behavior, and scRNAseq to figure it out:

19.03.2025 19:27 — 👍 4    🔁 1    💬 1    📌 2