Big thanks to Tolga Cagatay, who initiated this project in the Chook Lab in 2013 and carried it forward for many years. Grateful for close collaboration with the Daelemans & Lapalombella labs, and partners at Karyopharm and the Ready Lab.

14.12.2025 04:58 — 👍 0    🔁 0    💬 0    📌 0

SINE compounds activate exportin 1 degradation through an allosteric mechanism - Nature Chemical Biology Selinexor is a covalent inhibitor of the nuclear export receptor exportin 1 (XPO1). Wing, Fung and Kwanten et al. found that selinexor mediates XPO1 degradation through an allosteric molecule glue mec...

Selinexor is an allosteric degrader. It stabilizes XPO1/CRM1 to expose a cryptic ASB8 E3 ligase site, triggering ubiquitination. Led by Casey Wing, Joyce Fung & Bert Kwanten. #TargetedDegradation #Allostery

14.12.2025 04:57 — 👍 3    🔁 1    💬 1    📌 1

📝 Available online - the Review "The nuclear export receptor CRM1/XPO1 and its diverse cargoes" from Ralph Kehlenbach and @yuhminchook.bsky.social.

#CRM1 #Exportin1 #NuclearTransport #NuclearPoreComplex #RNAExport

Read it here: authors.elsevier.com/sd/article/S...

07.10.2025 15:51 — 👍 4    🔁 1    💬 0    📌 0

ScienceDirect.com | Science, health and medical journals, full text articles and books.

The review article on CRM1/XPO1 that Ralph Kehlenbach and I wrote (we made the figures too) is online at TIBS @cp-trendsbiochem.bsky.social. authors.elsevier.com/sd/article/S...

29.09.2025 14:50 — 👍 4    🔁 0    💬 0    📌 0