Quentin Leclerc

« AMR Data Challenge 2025 »
MESuRS remporte le prix Innovation avec Chloé Aupépin, Quentin Leclerc (@quentinlclrc.bsky.social) et Laura Temime.
Une compétition internationale organisée par Vivli où l’objectif est de proposer de nouvelles analyses pour mieux comprendre l’antibiorésistance

Overall, we identified optimal conditions to maximize quarantine hospital strategy benefits in an epidemic situation. We propose several recommendations to implement such a strategy when facing a virus with characteristics similar than SARS-CoV-2.

Thanks again to all co-authors for this work! 😁
7/7

Mental health status of health-care professionals working in quarantine and non-quarantine Egyptian hospitals during the COVID-19 pandemic - PubMed Female and younger age health care professionals were more prone to report adverse psychological symptoms. More and earlier screening for health-care professionals dealing with COVID-19, in addition t...

Of course, deciding whether or not to implement this strategy depends on other factors.
However, importantly, other studies did not find a difference in the mental health of HCWs between quarantine and non-quarantine hospitals, suggesting this would not be a barrier to implementation.

6/7

However, we find that this strategy only has a strong impact if:
- epidemic control is high in the community
- symptomatic HCWs comply well with self-isolation
Otherwise, increased transmission in the community counters the benefit of reduced nosocomial risk.

5/7

Epidemic curves showing that the quarantine hospital strategy leads to a small epidemic peak and attack rate in both HCWs and non-HCWs.

In a medium-sized city with two hospitals, we estimate that converting one of the two hospitals to a "quarantine hospital" can decrease the attack rate in HCWs by more than 10 percentage points, and the attack rate in non-HCWs by more than 20pp.

4/7

The contribution of hospital-acquired infections to the COVID-19 epidemic in England in the first half of 2020 - BMC Infectious Diseases Background SARS-CoV-2 is known to transmit in hospital settings, but the contribution of infections acquired in hospitals to the epidemic at a national scale is unknown. Methods We used comprehensive ...

As shown in other work (eg bmcinfectdis.biomedcentral.com/articles/10....), hospital-acquired infections can significantly drive overall COVID-19 dynamics, hence the importance of reducing them.

In our work, we show that the quarantine hospital strategy can be effective for this purpose.

3/7

Mathematical model diagram. The model captures movements of individuals (non-HCWs and HCWs) between the community, quarantine and usual hospitals.

Quarantine hospitals were fully dedicated to the care of COVID-19 infected patients & staffed by healthcare workers staying continuously inside for 1-2 week-long shifts.
To understand their impact compared to keeping usual hospital organisation, we built a model coupling hospitals & community 💻

2/7

An strategy generalised in Egypt to control nosocomial risk during the COVID-19 pandemic was the use of "quarantine hospitals" 🏥
In this new PLOS Comp Bio paper, we show how this strategy impacts epidemic dynamics 📉
w/ Théo Pinettes @kvn-jean.bsky.social Laura Temime @mesurs-cnam.bsky.social
1/7

Screenshot of the website for project proposal submission with the error "This site can't be reached"

What trying to submit a project proposal 24h before the deadline looks like:

(mais apparemment c'est la même chose chaque année pour les projets ANR, je découvre juste 🤓)

And no, I will never stop reminding people that these are burden *estimates* and not data, this is most certainly a hill I will die on 🙃

A great example to highlight the problem of publication metrics, as it shows that the line between "good" and "bad" science is blurry...
In AMR research, we all frequently refer to the IHME burden estimates, so this is worth keeping in mind 👇

YouTube video by MESuRS Cnam Laboratoire MESuRS | Modélisation, Épidémiologie & Risques Sanitaires

Mais au fait, qu'est ce qu'on fait au labo @mesurs-cnam.bsky.social ? 🦠😷💻

Il y a 2 semaines, j'ai présenté le labo en 3min lors du séminaire de rentrée du Cnam. Pour la Fête de la Science, je me suis dit que ça serait utile d'avoir cette intro en vidéo, et voilà ce que ça a donné 👇

Haha merci, je transmettrai à mon pote caché dans le public qui a joué au photographe pour l'occasion 😂

Impact and implementation of Pharmacy First: Interim findings | LSHTM Do you wonder what the uptake and implementation of the Pharmacy First service has been like? Are you curious about the impact on AMU and AMR? Come along to the AMR centre's seminar where we present

TODAY:

Find out how expanding antibiotic supply to pharmacies without a prescription is impacting #AMU, #AMR, antibiotics and patients in England!

12:45 online here:
www.lshtm.ac.uk/newsevents/e...

Photo du stand du laboratoire MESuRS à la fête de la science

Photo du stand du laboratoire MESuRS à la fête de la science

Photo du stand du laboratoire MESuRS à la fête de la science

Photo de 2 intervenants sur scène lors du jeu "Le juste nombre" à la fête de la science

Ce week-end c'était la Fête de la Science au @museeartsetmetiers.bsky.social avec +7500 personnes ! 🦠

Très heureux d'y avoir participé sur le stand du labo @mesurs-cnam.bsky.social, mais aussi avec @eloscicomm.bsky.social pour vous faire deviner des fun facts de bactéries !

A l'année prochaine...?

Ce weekend, direction la Fête de la Science au @museeartsetmetiers.bsky.social ! 👇

On y sera avec @mesurs-cnam.bsky.social dès le vendredi soir, et toute la journée samedi & dimanche : rendez-vous sur notre stand pour en apprendre plus sur les dynamiques invisibles des épidémies ! 🦠

🧬 𝐌𝐢𝐬𝐬𝐢𝐨𝐧 : 𝐬𝐚𝐮𝐯𝐞𝐫 𝐮𝐧 𝐦𝐮𝐬é𝐞 𝐝’𝐮𝐧𝐞 é𝐩𝐢𝐝é𝐦𝐢𝐞 ! 🚀

Rejoignez 𝐌𝐄𝐒𝐮𝐑𝐒 à la 𝐅ê𝐭𝐞 𝐝𝐞 𝐥𝐚 𝐒𝐜𝐢𝐞𝐧𝐜𝐞 #FDS2025

🗓️ 3-5 oct – Musée LeCnam @museeartsetmetiers.bsky.social

🔍 Devenez épidémiologiste : Simulation | modélisation | stratégie

⚖️ Prenez les décisions. Soyez le héros ce week-end !

🔗 Info+ urls.fr/qa_h2k

Mon programme détaillé pour la fête des sciences. Toutes les informations sont dans le texte du post bluesky !

Programme pour moi:
- tous les jours : stand "Révéler les dynamiques invisibles des épidémies"
- vendredi 21h05: "Juste Nombre", tentez votre chance pour gagner des lots !
- vendredi 22h : "Speed Searching", je répondrai à vos questions les plus folles (eg: quelle quantité de café je bois par jour?)

Ce weekend, direction la Fête de la Science au @museeartsetmetiers.bsky.social ! 👇

On y sera avec @mesurs-cnam.bsky.social dès le vendredi soir, et toute la journée samedi & dimanche : rendez-vous sur notre stand pour en apprendre plus sur les dynamiques invisibles des épidémies ! 🦠

🔬 Du 3 au 5 octobre, le #MuAM lance 72h de #sciences !Chercheurs, ingénieurs et vulgarisateurs partageront leurs expériences à travers une programmation festive et pédagogique 👉 www.arts-et-metiers.net/musee/72h-de...
#recherche #innovation #FêteDeLaScience #FDS2025 #Impro #DJSet #laboratoires

Annonce_CPJ_Cnam | Nathalie Lagarde Un poste de Chaire de Professeur Junior (CPJ) est ouvert dans notre équipe de bioinformatique structurale appartenant au laboratoire GBCM du Conservatoire National des Arts et Métiers (Paris). 👉 Profi...

A junior chair professor position in computer science / chemoinformatics / structural bioinformatics is available in my former team in CNAM, Paris, France

Please contact Nathalie Lagarde for more details (nathalie.lagarde@lecnam.net)

WHAT DOES IT MEAN TO BE INFECTED? | David Hodgson Defining infection is like reading tarot cards - the interpretation depends on who’s asking and what they’re looking for. You wake up with a sore throat. You take a lateral flow...

What does it really mean to be “infected”?

PCR? Symptoms? Antibodies? Being able to pass it on?

I’ve written a blog digging into why infection isn’t a simple on/off switch, and why the definition you choose matters for modelling, vaccines, & public health.

davidhodgson.me/post/sm1_wha...

Okay volume 2 of the AMR People Pack is now full!
Two lists with 299 amazing accounts of AMR related things so follow along. Plus there's the "Antimicrobial Resistance" feed if you haven't already got that pinned.
Need 8 people to start Vol 3
Vol 2: go.bsky.app/EUY2FUJ
Vol 1: go.bsky.app/KkZfvrh

“Supercontactors” are the hubs of hospital networks. Controlling their interactions, can help dramatically slow down the spread. Our latest PrIMAVeRa study showcases that targeting them reduced MRSA cases by about 20%.

👉 𝗥𝗲𝗮𝗱 𝘁𝗵𝗲 𝗳𝘂𝗹𝗹 𝗽𝗮𝗽𝗲𝗿 𝗮𝘁: https://bit.ly/468hBgo

Why antibiotics are like fossil fuels They helped create the modern world but are dangerously overused. How can we harness them sustainably?

Les antibiotiques sont une ressource non-renouvelable puisqu'ils finiront par ne plus être efficaces face à une antibioresistance en augmentation.
Là où cette analogie est particulièrement pertinente, c'est pour souligner l'importance des alternatives "renouvelables", tels que les vaccins !

Bad Vaxx A wild game about a serious subject

The new Bad Vaxx game is a nice example of effective science communication via videogames, in this case to raise awareness about vaccine misinformation.
Give it a try in villain mode though, from a game-design perspective this is much more impactful than playing the hero !
www.badvaxx.com

LLMs are not like you and me—and never will be. Unpacking a popular new example from an AI researcher at Google DeepMind

“LLMs are an echo of recorded memories. They are not fresh thoughts. People are confusing an echo for cognition.”

garymarcus.substack.com/p/llms-are-n...

Why antimicrobial resistance messaging fails: qualitative insights interpreted through the elaboration likelihood model AbstractBackground. Antimicrobial resistance (AMR) is a global threat, yet public awareness remains low. This study examined perceptions of current AMR com

🦠 Why do public messages about #AntimicrobialResistance (AMR) fall flat?
Our research shows that most #AMR messaging is too technical, unclear, and lacks personal relevance
💡 Want to change minds? Make it personal, positive, and punchy.

shorturl.at/otjt5

Give Visual Studio Code a go! Plus, it works with a ton of languages, so if you want to try something else later you can reuse that 😉

Plasmids link antibiotic resistance genes and phage defense systems in E. coli Phage therapy has been proposed as an alternative to antibiotics to treat resistant infections. However, we have a limited understanding of how antibiotic resistance genes (ARGs) associate with bacter...

New pre-print from my lab!
Plasmids link antibiotic resistance and phage defense.

E.coli plasmids are hotspots for both antibiotic resistance and phage defense. Phage therapy has the potential to accidentally select for antibiotic resistance!!!
#microsky#AMR#phage

www.biorxiv.org/content/10.1....