Jan Böttcher

Ablation of prostaglandin E2 signalling through dual receptor knockout in CAR T cells enhances therapeutic efficacy in solid tumours - Nature Biomedical Engineering Targeted ablation of prostaglandin E2 (PGE2) signalling in CAR T cells enhances their activity in PGE2-rich solid tumours, with demonstrations of efficacy in vitro, in mouse xenografts and in patient-...

Excited to share our new collaborative study with the Sebastian Kobold lab! www.nature.com/articles/s41...

By deleting the PGE2 receptors EP2/EP4, we render CAR T cells resistant to suppression in solid tumors - boosting persistence and anticancer activity in preclinical models and patient samples.

Thanks Sophie!

Many congratulations!

Thrilled to share that my #ERCCoG EICO-CODE has been selected for funding!🚀 We will study how eicosanoids shape T cell immunity across tissues. 🧬🔬🧪✨ I am deeply grateful for this recognition of the team’s work - and to everyone supporting us in our research. Exciting years ahead!

Less than one week left to apply 🔜

Very happy to join the team of the CRC 1479 initiative for the 2nd funding period to study mechanisms of immune evasion in cancer! www.sfb1479.uni-freiburg.de/news/great-n...

I fully agree Nick - and we still know little about the exact roles of these molecules in cancer and tumor immunology

Prostaglandins in cancer revisited: principles of production, mechanisms of immune regulation, and therapeutic perspectives The cyclooxygenase (COX) signaling pathway is frequently dysregulated in cancer, resulting in aberrant production of prostaglandins - a distinct class of b

🚨Our lab has a new review article out today!
We revisit prostaglandins in cancer—how they’re produced, how PGE₂ reshapes immune responses in tumors, and what this means for future therapies.
Work led by team members Erik Müller & Bastian Kruse @bkru.bsky.social
🔗 doi.org/10.1182/bloo...

TNF and type I interferon crosstalk controls the fate and function of plasmacytoid dendritic cells Nature Immunology - Plasmacytoid dendritic cells are type 1 interferon (IFN-I)-producing antiviral specialists that have been shown to be able to differentiate into conventional dendritic cells....

Idoyaga and colleagues suggest that pDCs can lose the ability to secrete IFN-I and acquire the transcriptional, epigenetic and functional features of cDCs. Read it here: rdcu.be/eBB5e
www.nature.com/articles/s41...

Wonderful to see Klaus Rajewsky honored with the first ever EFIS Lifetime Achievement Award! #iIUIS2025 in Vienna.

Many congratulations to all awardees!

🍾Many congratulations to former PhD student Philippa Meiser - now Postdoc with Laura Mackay @thedohertyinst.bsky.social - for receiving this years PhD award 🥇 from @dgfi-org.bsky.social at @iuis-online.bsky.social !

Interesting study by @reisesousalab.bsky.social, highlighting functionally distinct states of activated cDC1s in tumors. 🔬🧪

Many congratulations!

Looking forward to great talks and discussions with friends and colleagues in London👇!

Adaptive immunity in barrier tissues Immune responses lie at the heart of almost every aspect of human health, including host responses to infection, autoimmunity, cancer, metabolism and aging. While adaptive immune responses by B and T…

🚨🦠🔬 Last month to register to the EMBO workshop on Adaptive Immunity in Barrier Tissues.

📍 Where: Basel, Switzerland
📅 When: 26th–29th August 2025
📝 Registration deadline: 30th May 2025

Childcare support & travel grants from @embo.org and @efis-immunology.bsky.social

#EMBOBarrierTissues

Find us here : www.medizin.uni-tuebingen.de/de/das-klini...

thrilled to share that I’ve officially been appointed as Professor of Experimental Immunology @unituebingen.bsky.social, with the lab based at both the M3 Research Center and the Institute of Immunology, continuing interdisciplinary and translational research in cancer and tissue immunology 🧪🧫🧬🔬

📣 !! JOB ALERT for PhD students !!

My lab is moving to the M3 Research Center at the University of Tübingen and is looking for PhD students who are enthusiastic about translational research.
If you are, read on below ⬇️

Great to see this out in print! Many congratulations!

We're hiring at all levels! Feel free to reach out if you have questions:
academicjobsonline.org/ajo/jobs/29722

USAid: Die Zerstörung hat schon begonnen Ob Projekte gegen HIV, Malaria oder vernachlässigte Tropenkrankheiten: Die USA streichen ihre medizinische Entwicklungshilfe. Die Folgen sind schon jetzt dramatisch.

Unsere Recherchen zu den Auswirkungen des US-Hilfsstopps sind heute bei Zeit Online nachzulesen mit Stimmen aus den USA, Kenia, Thailand, Südafrika und dem Sudan:
#USAID #PEPFAR

www.zeit.de/gesundheit/2...

Scientific institutions have a long history of anticipatory obedience Societies should learn from this and speak up to support inclusion

„Anyone who has studied science under the Nazis, as I did for my book Serving the Reich, cannot fail to be dismayed and alarmed at the parallels in the response so far of scientific institutions and academies to the purges and abuses of power following Trump’s executive orders“ 🧪

NIH cuts billions of dollars in biomedical funding, effective immediately The move halts a large slice of money for most universities and research institutions virtually overnight, imperiling vital research in everything from cancer to heart disease.

NIH has cut billions of dollars in biomedical funding, effective immediately
The move halts a large slice of money for most universities and research institutions virtually overnight, imperiling vital research in everything from cancer to heart disease.

www.washingtonpost.com/health/2025/...

Four lessons COVID taught us about the immune system In the midst of pandemic upheaval, researchers have gained fundamental insights about how the body fends off infections.

Some learnings about our immune system from Covid @nature.com
—importance of T cells (not just neutralizing antibodies)
—key role of interferons, the first line of defense
—hybrid immunity
—underpinnings of Long Covid

www.nature.com/articles/d41...

Join the next #globalimmuno talk this Wednesday, January 15th, at 9 am PST, 12 Noon EST, 4 pm GMT featuring AAI Member Jenny Ting!

We look forward to hearing many more impactful Global ImmunoTalks from other AAI members in 2025.

ucsd.zoom.us/j/91053505061

Characterizing and targeting glioblastoma neuron-tumor networks with retrograde tracing Rapid integration of glioblastoma into neuronal circuits promotes glioblastoma invasion and growth, as shown by rabies-based retrograde tracing. Targeting of neuron-tumor networks with pharmacological or rabies-mediated disconnection offers therapeutic potential.

🧪 elegant study using rabies-based retrograde tracing to map and manipulate GBM-neuron networks. www.cell.com/cell/fulltex...

Friends, it's fun to see the #immunology community continue to grow! I created a 4th Starter Pack to help folks find each other. If you're an immunologist and you don't see yourself on the lists, let me know 🧪

go.bsky.app/PY5tCas

go.bsky.app/FmERUoD

go.bsky.app/6aT6qDS

go.bsky.app/QSEPDoj

Now I am even more sad not to be able to make it to #EMDS in Vienna this years would have been great to join in on the celebrations @obenaufa.bsky.social !

Many congratulations Anna & Anais, great to see this finally out in print!