Kevin Zhang

We're back from the @theaacr.bsky.social Special Conference on Early Onset Cancers! A major highlight was the update from Mark Foundation-Waxman Foundation grantee Ashani Weeraratna on her research into how the aging tumor immune microenvironment influences tumor progression. #AACRearlyonset25

Are you using the right tumor micro environment model? Cancer is a disease of aging @sitcancer.bsky.social #SITC25 great session at the annual meeting on the aged immune system and the tumor micro environment moderated by Drs DA and A Weeraratna.

How to disconnect therapy-resistant tumor networks in glioblastoma?

In our paper, online @Cancer Discovery, we built an anti-tumor microtube (TM) screening pipeline and found that Protein Kinase C activators disrupt TMs, silence Ca²⁺ “pacemakers” and boost radiotherapy.
doi.org/10.1158/2159...

Unravelling the genetics and epigenetics of the ageing tumour microenvironment in cancer - Nature Reviews Cancer In this Review, Easwaran and Weeraratna outline how ageing leads to epigenetic alterations in the tissue microenvironment, enhancing clonal expansion of mutations and ultimately increasing cancer risk.

Review 🚨
Easwaran&Weeraratna outline how #ageing leads to epigenetic alterations in the #TME, enhancing clonal expansion of mutations and ultimately increasing cancer risk.
📖 👇

Cancer neuroscience of brain metastasis: When in Rome, do as the Romans do In this comprehensive review, Karreman & Winkler explore how neural influences on the brain’s metastatic process govern brain tropism, colonization, and growth. Conversely, metastatic cancer has disti...

www.cell.com/neuron/fullt...

In the United States, cases of early-onset cancer are on the rise. Featured in a recent #AACRBlog on early-onset cancer, this Cancer Discovery article explores how changes in risk factor prevalence and/or improvements in detection could affect risk across an age range. Read more: buff.ly/NLssp4H

‘Sleeping’ cancer cells in the lungs can be roused by COVID and flu Inflammation from the respiratory infections seems to be the culprit, study in mice finds.

Hidden in the lungs of some breast cancer survivors are tumour cells that can remain dormant for decades — until they one day trigger a relapse

go.nature.com/41iIdJR

Biochemistry and Molecular Biology PhD Defense Seminar. Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment. Alexis Carey. PhD Candidate, Weeraratna Lab, Biochemistry and Molecular Biology Department. Cellular and Molecular Medicine Program.

Congratulations Dr. Alexis Carey! Alexis Carey is in the Cellular & Molecular Medicine program and successfully defended her PhD today. In today's seminar she shared her about work in the Weeraratna Lab on “Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment”

Johns Hopkins Kimmel Cancer Center Podcasts: Cancer Matters with Dr Bill Nelson - Melanoma Research Dr Bill Nelson talks with Dr Ashani Weeraratna about her work in melanoma research, the progress that has been made in treating patients with melanoma, and the importance of federal research funding i...

Listen to BDP @ashi-w.bsky.social discuss her work in #melanoma research on the Kimmel Cancer Center podcast, Cancer Matters.

hopkinskimmel.libsyn.com/cancer-matte...

YouTube video by CSHL Leading Strand Interview with Ashani Weeraratna

"No tumor is an island" and "oncology recapitulates embryology" - a fascinating conversation with the incredible @ashi-w.bsky.social at the CSHL symposium on aging.

We talk about how cancer rates increase with age, the T(I!)ME, and the role of Wnt signaling www.youtube.com/watch?v=_Txf...

This year’s 11 NextGen Stars will share their findings on cancer cartography, the dark proteome, cancer-resistant tissues, and more at #AACR25. Learn more about their work and its future implications on the #AACRBlog: www.aacr.org/blog/2025/04...

Increased SOX10, p16, and Cyclin D1 Immunoreactivity... : The American Journal of Surgical Pathology available stains, we hypothesize that a limited panel including SOX10, p16, and cyclin D1 may be useful in differentiating mitogen-activated protein (MAP) kinase-activated low-grade gliomas from piloi...

We explore the utility of an immunohistochemical panel consisting of Sox10, p16, and cyclin D1 in differentiating MAP kinase-activated low-grade gliomas from piloid gliosis.

#neuropath #pathsky

journals.lww.com/ajsp/fulltex...

Congratulations to the new #AACR #TME working group Chair elect!!!
The one and only (best friend and colleague) @ashi-w.bsky.social

www.aacr.org/professional...

Golden weekend

🧵Just in time for
: New research from the Venkataramani lab @CellCellPress
maps how brain tumor cells create extensive neural networks in glioblastoma. Check out our paper here: authors.elsevier.com/sd/article/S...
@ekinreyhan.bsky.social

@svenjaktetzlaff.bsky.social

1/15

A sausage shaped tumor with attached filamentous band

A squash preparation of a fibrillary neoplasm with myxoid background

Small rosettes in a squash preparation

H&E stained section of papillae with myxoid cores

Myxopapillary ependymoma grossly has a characteristic sausage-shaped appearance. Commonly found associated with the filum terminale, it has a fibrillary glial appearance in a myxoid background. Though previously categorized as CNS WHO grade 1, it is now considered grade 2 #pathsky #medsky #neuropath

Could I be added to the list? Thanks!

Reflections on Advances in Cancer Research in 2024 There have been many impactful advances in basic, translational, and clinical cancer research in 2024. An important mission of Cancer Discovery is to ensure the timely dissemination of innovative ways...

Advances in cancer research in 2024

aacrjournals.org/cancerdiscov...

Among the Cancer-related Starter Packs currently available, I didn’t find one on Tumor Microenvironment.

Here, the list of who I found until now… If you want to be added, please reply below!
go.bsky.app/CtQMJyW

go.bsky.app/7xTwrrn

🧠 barriers & neurovasculature starter pack - please reply here if you are not on it yet & would like to be added 😊 go.bsky.app/RB6RXKy