Alison Forrester

Dear all, I have coined a phrase:
To A.Iron
Definition: To polish text using AI

@academic-chatter.bsky.social

Im not going to be sharing my photos of our glorious day on Ile de Batz….. maybe of the dinner later?? 😉😉

The bridge-like lipid transport protein VPS13C/PARK23 mediates ER–lysosome contacts following lysosome damage - Nature Cell Biology Wang et al. show the recruitment of the lipid channel protein VPS13C and formation of VPS13C-dependent contacts between endoplasmic reticulum and lysosomes after lysosomal damage.

📄Shoutout to our 2019 Research Center awardees at Yale (@pdc-lab.bsky.social, @shawnferguson.bsky.social) for their new publication on the bridge-like lipid transport protein VPS13C/PARK23 mediates ER–lysosome contacts following lysosome damage:
www.nature.com/articles/s41...

For clear thinking, cultivate passionate indifference. Buddhists call it non-attachment. We all have hopes, desires and ambitions. Non-attachment means acknowledging them, accepting them, and then not inserting them into a process that has nothing to do with you. podcasts.apple.com/us/podcast/n...

Growth factor-triggered de-sialylation controls glycolipid-lectin-driven endocytosis - PubMed Glycolipid-lectin-driven endocytosis controls the formation of clathrin-independent carriers and the internalization of various cargos such as β1 integrin. Whether this process is regulated in a dynam...

Congrats to the Johannes lab! 👏 E MacDonald, @aforrester.bsky.social @cessvala.bsky.social E Dransart, A Akhil Shp, L Leconte, V Chambon, D Ghosh, A Pinet, D Bhatia, B Lombard, D Loew, MShafaq-Zadah, @christianwunder.bsky.social
@institutcurie.bsky.social
pubmed.ncbi.nlm.nih.gov/39984654/

📣 We are advertising for a postdoc to join our team at the University of Edinburgh! Our lab studies gene regulatory mechanisms in development, and how genetic changes may impact these processes to alter development and shape human craniofacial form and function 🧬🧪

The 16th ER & Redox club meeting ends. THANK YOU to co-organiser @fenech-lab.bsky.social & to everyone for outstanding presentations, discussions, posters and fun over the last 4 days in Namur. Huge thanks to @unamur.bsky.social @biologists.bsky.social @febspress.bsky.social for support and funding!

Thank you for the commentary Ishier! It's been great having everyone here!

The pathways of secretory cargo export at the endoplasmic reticulum Nature Communications - The author presents an overview of the complex challenge of protein export from the Endoplasmic Reticulum, and discusses how cells may deploy novel pathways utilizing...

A terrific perspective from Vivek Malhotra @naturecomms.bsky.social on the fundamental importance of pathways and mechanisms by which cells secrete proteins, ensuring their delivery in the correct quantities and at the appropriate times.
Interesting section on unanswered questions.

rdcu.be/ecb2B

The importance of delivering Recherche d'Avenir – research for the future In recent years, several European countries, including France, have reduced their investment in scientific research, with biomedical research taking a significant hit. The primary casualty is basic re...

journals.biologists.com/jcs/article/...

Lab manager position open. Does the idea of helping a busy structural cell biology and biochemistry-based drug discovery lab stave off chaos appeal to you? Apply now at tinyurl.com/4dsvpwbw

Just a week left to apply for this postdoc position in my lab in Oxford.

Spatial N-glycan rearrangement on α5β1 integrin nucleates galectin-3 oligomers to determine endocytic fate Membrane glycoproteins frequently adopt different conformations when altering between active and inactive states. Here, we discover a molecular switch that exploits dynamic spatial rearrangements of N...

... and soon the structural glycoswitch: www.biorxiv.org/content/10.1...

I'm thrilled that our paper is now online: www.nature.com/articles/s41... describing an elegant pH-triggered CIE. Thanks to everyone who made it an exciting and successful project @ewanmacdonald.bsky.social @cessvala.bsky.social @christianwunder.bsky.social #fluorescencefriday #microscopymonday

Flotillins in membrane trafficking and physiopathology Flotillin 1 and 2 scaffold sphingolipid-rich membrane microdomains involved in endocytosis and  endolysosome maturation through the generation of sphingosine 1-phosphate (S1P) by sphingosine kinase 2...

I'm happy to share our review latest review on flotillins! We discuss the recent insights into the structure of these interesting proteins from cyro-EM studies.
doi.org/10.1111/boc....

Going Green at the Department of Biology and Faculty of Medicine at the University of Namur! We've worked on it for a year, now it's time to go big 😁💚🔬 The initiative seems to be making some waves and it's great to see som much enthusiasm! @fsilvestrelab.bsky.social #sustainability #GreenLab

ÅNGSTRÖM-RESOLUTION IMAGING OF CELL-SURFACE GLYCANS 🧬🎨🍬

The glycocalyx, our cells' sugar coat, holds secrets in immunology, cancer, viral infections, and more. Visualizing its molecular architecture was impossible… until now. #glycotime #microscopy

www.biorxiv.org/content/10.1...

Inscriptions for the 27th annual meeting of the Club Exo-Endo are opened. Please register on exoendo.org !!

Live imaging of the extracellular matrix with a glycan-binding fluorophore - Nature Methods Rhobo6 is a cell-impermeable small-molecule fluorophore that displays reversible fluorogenic binding to glycans, making it a general, wash-free, and non-perturbative label for the extracellular matrix...

Check it out, powerful new method for optical imaging of the live ECM, from @hhmijanelia.bsky.social Group Leader Kayvon Pedram #proudofalumni #glycotime

www.nature.com/articles/s41...

It’s incredibly hard to study lipids in biological membranes on the nanoscale. You need near-perfect information on both membrane ultrastructure and lipid density, which usually isn’t attainable. Lipid-CLEM brought to you by @mathilda95.bsky.social changes that.
www.biorxiv.org/content/10.1...

Our plasmids for editing are now on @addgene.bsky.social! www.addgene.org/Francesca_Bo... I promise you a detailed protocol on how to use them is coming very very soon! Currently proofreading :)

Excited to see work led by @autophazeke.bsky.social, @minghaochen.bsky.social, Thanh Nguyen, and Ainara Claveras out in @science.org today, the culmination of a 15-year project to understand structurally how the synthesis of the critical lipid of autophagy, PI3P, is regulated. tinyurl.com/ywvjh8u4

We're happy to announce the launch of the new website of the Club Exo-endo. From the site, you can register for the annual meeting, register as a new member, advertise a position, apply for the thesis prize or post your latest publication. Please visit us at exoendo.org and make it interactive !

The #MembraneTrafficking seminar series is back this Thursday, and we are very happy to start the 2025 season with two talks by early career scientists: Adam Krahn from the Glick Lab at University of Chicago and @jkefauver.bsky.social at CINN-CSIC, Spain.

Just wrapped up an incredible meeting in Innsbruck with an amazing group of membrane traffickERs. The intimate, congenial setting fostered open, positive discussions and constructive critiques—intense and inspiring. Huge thanks to Hesso @hessofarhan.bsky.social for organising!

It’s been a gEReat few days with a wondERful group! A million thanks to @hessofarhan.bsky.social for organising it. I’m already excited about the next one! #It’snotanERGIC…isitanERGIC?

The first supper before our ERES meeting

Lets allow ourselves an apero break after the next few slides are done!

Trafficking myself to @i-med.ac.at for a few days organised by @hessofarhan.bsky.social to witness classic ERES behaviour and a concentration of ERES fans and experts. Nice journey so far with trafficking chaperone @ishier.bsky.social

Exciting news! #MembraneTrafficking online seminars with @felixmendu.bsky.social @franbottanelli.bsky.social and me are back!
Check the spectacular Jan-April 2025 lineup.
Details (Zoom links, calendar invites) on the mailing list, Slack group & website: felixcampelo.wixsite.com/membranetraf...