Taxiarchis Katsinelos

I am immensely grateful to Michel Goedert and @sjorsscheres.bsky.social for their guidance and mentoring and to all the people, who contributed to this work, Sofia Lövestam, @qcxy8886.bsky.social, Benjamin Ryskeldi-Falcon, Jennifer Macdonald, Gabriel Stephenson, Bernardino Ghetti, and Ann McKee.

This improved model is able to detect tau seeds with specificity towards seeds from 3R+4R tauopathies and can be used to further our understanding of the mechanisms involved in seeded aggregation.

We also used electron cryo-microscopy to structurally characterise the AD-seeded tau filaments from the biosensor cells and determined that they are able to reproduce the Alzheimer tau fold.

In our work we rationally designed a new sensitive HEK-based biosensor cell line that is able to specifically detect tau seeds from 3R+4R tauopathies, such as Alzheimer's disease (AD) and Chronic Traumatic Encephalopathy (CTE).

Seeding biosensor cell line that reproduces the Alzheimer tau fold The assembly of tau protein into amyloid filaments through templated seeding is believed to underlie the propagation of pathology in neurodegenerative diseases, such as Alzheimer’s disease (AD) and ot...

I am delighted to share that our new manuscript is published as an online Pre-proof at the Journal of Biological Chemistry!! 🎉
www.jbc.org/article/S002...